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Protein Ontology report - C-1-tetrahydrofolate synthase, cytoplasmic
PR:000010722 - http://purl.obolibrary.org/obo/PR_000010722
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000010722   
  PRO nameC-1-tetrahydrofolate synthase, cytoplasmic 
  Synonyms
PRO-Short-label: EXACT:MTHFD1
Gene-based: RELATED:MTHFC | MTHFD
Other: EXACT:C1-THF synthase
  Definition"A protein that is a translation product of the human MTHFD1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification1                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000010722
C-1-tetrahydrofolate synthase, cytoplasmic
MTHFD1
"A protein that is a translation product of the human MTHFD1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:O96553
C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly)
fly-MTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of fruit fly." [OMA:O96553, PRO:DNx]

organism-sequence


PR:O96553-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform B (fruit fly)
fly-MTHFD1/iso:B
"A C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96553-1." [PRO:DNx, UniProtKB:O96553]

organism-sequence


PR:O96553-2
C-1-tetrahydrofolate synthase, cytoplasmic isoform A (fruit fly)
fly-MTHFD1/iso:A
"A C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96553-2." [PRO:DNx, UniProtKB:O96553]

organism-gene


PR:P11586
C-1-tetrahydrofolate synthase, cytoplasmic (human)
hMTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11586]

organism-sequence


PR:P11586-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (human)
hMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000048468
C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form (human)
hMTHFD1/InitMet-
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has had the initiator methionine removed. UniProtKB:P11586, 2-935." [PRO:DNx, Reactome:R-HSA-200641]

organism-modification


PR:000066738
C-1-tetrahydrofolate synthase, cytoplasmic methylated 1 (human)
hMTHFD1/Me:1
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been methylated on the residue at the position equivalent to Cys-918 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Cys-918, MOD:00660." [IEDB_epitope:1054804, PRO:DNx]

organism-modification


PR:000067839
C-1-tetrahydrofolate synthase, cytoplasmic methylated 2 (human)
hMTHFD1/Me:2
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been methylated on the residue at the position equivalent to Cys-691 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Cys-691, MOD:00660." [IEDB_epitope:1015620, PRO:DNx]

organism-modification


PR:000074042
C-1-tetrahydrofolate synthase, cytoplasmic deaminated 1 (human)
hMTHFD1/Deam:1
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been deaminated on the residue at the position equivalent to Asn-932 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Asn-932, MOD:00684." [IEDB_epitope:1574534, PRO:DNx]

organism-modification


PR:000078529
C-1-tetrahydrofolate synthase, cytoplasmic deaminated 2 (human)
hMTHFD1/Deam:2
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been deaminated on the residue at the position equivalent to Gln-807 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Gln-807, MOD:00685." [IEDB_epitope:1339750, PRO:DNx]

organism-modification


PR:000081133
C-1-tetrahydrofolate synthase, cytoplasmic cysteinylated 1 (human)
hMTHFD1/Cyst:1
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been cysteinylated on the residue at the position equivalent to Cys-691 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Cys-691, MOD:00765." [IEDB_epitope:1004141, IEDB_epitope:1336789, PRO:DNx]

organism-modification


PR:000083336
C-1-tetrahydrofolate synthase, cytoplasmic deaminated 3 (human)
hMTHFD1/Deam:3
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has been deaminated on the residue at the position equivalent to Gln-285 of the amino acid sequence represented by UniProtKB:P11586. UniProtKB:P11586, Gln-285, MOD:00685." [IEDB_epitope:1989707, PRO:DNx]

organism-gene


PR:P27653
C-1-tetrahydrofolate synthase, cytoplasmic (rat)
rMTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of rat." [OMA:P27653, PRO:DNx]

organism-sequence


PR:P27653-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (rat)
rMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of rat." [PRO:DNx]

organism-gene


PR:Q54G53
formate-dihydrofolate ligase (Dictyostelium discoideum)
Dicty-MTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]

organism-gene


PR:Q8WZJ7
C-1-tetrahydrofolate synthase, cytoplasmic (Schizosaccharomyces pombe 972h-)
Spom972h-MTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]

organism-gene


PR:Q922D8
C-1-tetrahydrofolate synthase, cytoplasmic (mouse)
mMTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of mouse." [OMA:Q922D8, PRO:DNx]

organism-sequence


PR:Q922D8-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (mouse)
mMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-gene


PR:Q9SPK5
formate--tetrahydrofolate ligase (Arabidopsis thaliana)
At-MTHFD1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]

sequence


PR:000038850
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1
MTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11586-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P11586-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (human)
hMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:P27653-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (rat)
rMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of rat." [PRO:DNx]

organism-sequence


PR:Q922D8-1
C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (mouse)
mMTHFD1/iso:1
"A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

modification


PR:000020644
C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form
MTHFD1/InitMet-
"A C-1-tetrahydrofolate synthase, cytoplasmic that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000048468
C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form (human)
hMTHFD1/InitMet-
"A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has had the initiator methionine removed. UniProtKB:P11586, 2-935." [PRO:DNx, Reactome:R-HSA-200641]