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Protein Ontology report - mediator of RNA polymerase II transcription subunit 1
PR:000010279 - http://purl.obolibrary.org/obo/PR_000010279
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010279   
  PRO namemediator of RNA polymerase II transcription subunit 1 
  Synonyms
PRO-Short-label: EXACT:MED1
Gene-based: RELATED:ARC205 | CRSP1 | CRSP200 | Crsp210 | DRIP230 | PBP | PPARGBP | RB18A | TRAP220
Other: EXACT:activator-recruited cofactor 205 kDa component | mediator complex subunit 1 | p53 regulatory protein RB18A | peroxisome proliferator-activated receptor-binding protein | PPAR-binding protein | thyroid hormone receptor-associated protein complex 220 kDa component | thyroid receptor-interacting protein 2 | TR-interacting protein 2 | Trap220 | TRIP-2 | vitamin D receptor-interacting protein complex component DRIP205
RELATED:Drip205 | Pparbp | Trip2
  Definition"A protein that is a translation product of the human MED1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010279

mediator of RNA polymerase II transcription subunit 1

MED1


"A protein that is a translation product of the human MED1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q15648

mediator of RNA polymerase II transcription subunit 1 (human)

hMED1


"A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15648]


organism-sequence



PR:Q15648-1

mediator of RNA polymerase II transcription subunit 1 isoform h1 (human)

hMED1/iso:h1


"A mediator of RNA polymerase II transcription subunit 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15648-1." [PRO:DNx, UniProtKB:Q15648]


organism-sequence



PR:Q15648-3

mediator of RNA polymerase II transcription subunit 1 isoform 2 (human)

hMED1/iso:2


"A mediator of RNA polymerase II transcription subunit 1 isoform 3 that is encoded in the genome of human." [PRO:HJD]


organism-modification



PR:000070493

mediator of RNA polymerase II transcription subunit 1 phosphorylated 1 (human)

hMED1/Phos:1


"A mediator of RNA polymerase II transcription subunit 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1187 of the amino acid sequence represented by UniProtKB:Q15648-1. Example: UniProtKB:Q15648-1, Ser-1187, MOD:00046." [IEDB_epitope:2148197, PRO:DNx]


organism-modification



PR:000078282

mediator of RNA polymerase II transcription subunit 1 methylated 1 (human)

hMED1/Me:1


"A mediator of RNA polymerase II transcription subunit 1 (human) that has been methylated on the residue at the position equivalent to Cys-443 of the amino acid sequence represented by UniProtKB:Q15648-1. Example: UniProtKB:Q15648-1, Cys-443, MOD:00660." [IEDB_epitope:1009899, IEDB_epitope:1009900, PRO:DNx]


organism-modification



PR:000079366

mediator of RNA polymerase II transcription subunit 1 cysteinylated 1 (human)

hMED1/Cyst:1


"A mediator of RNA polymerase II transcription subunit 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-443 of the amino acid sequence represented by UniProtKB:Q15648-1. Example: UniProtKB:Q15648-1, Cys-443, MOD:00765." [IEDB_epitope:1569244, PRO:DNx]


organism-gene



PR:Q925J9

mediator of RNA polymerase II transcription subunit 1 (mouse)

mMED1


"A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of mouse." [OMA:Q925J9, PRO:DNx]


organism-sequence



PR:Q925J9-1

mediator of RNA polymerase II transcription subunit 1 isoform 1 (mouse)

mMED1/iso:1


"A mediator of RNA polymerase II transcription subunit 1 isoform 1 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]

Yes

Yes
organism-sequence



PR:Q925J9-2

mediator of RNA polymerase II transcription subunit 1 isoform 2 (mouse)

mMED1/iso:2


"A mediator of RNA polymerase II transcription subunit 1 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]


organism-sequence



PR:Q925J9-3

mediator of RNA polymerase II transcription subunit 1 isoform 3 (mouse)

mMED1/iso:3


"A mediator of RNA polymerase II transcription subunit 1 isoform 3 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]


organism-sequence



PR:Q925J9-4

mediator of RNA polymerase II transcription subunit 1 isoform 4 (mouse)

mMED1/iso:4


"A mediator of RNA polymerase II transcription subunit 1 isoform 4 that is encoded in the genome of mouse." [PMID:11471062, PRO:HJD]


organism-gene



PR:Q9VP05

mediator of RNA polymerase II transcription subunit 1 (fruit fly)

fly-MED1


"A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of fruit fly." [OMA:Q9VP05, PRO:DNx]


sequence



PR:000028920

mediator of RNA polymerase II transcription subunit 1 isoform 1

MED1/iso:1


"A mediator of RNA polymerase II transcription subunit 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q925J9-1 or a 1:1 ortholog thereof." [PMID:16141072, PRO:HJD]


organism-sequence



PR:Q925J9-1

mediator of RNA polymerase II transcription subunit 1 isoform 1 (mouse)

mMED1/iso:1


"A mediator of RNA polymerase II transcription subunit 1 isoform 1 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]

Yes

Yes
sequence



PR:000028922

mediator of RNA polymerase II transcription subunit 1 isoform 2

MED1/iso:2


"A mediator of RNA polymerase II transcription subunit 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q925J9-2 or a 1:1 ortholog thereof." [PMID:16141072, PRO:HJD]


organism-sequence



PR:Q925J9-2

mediator of RNA polymerase II transcription subunit 1 isoform 2 (mouse)

mMED1/iso:2


"A mediator of RNA polymerase II transcription subunit 1 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]


sequence



PR:000028924

mediator of RNA polymerase II transcription subunit 1 isoform 3

MED1/iso:3


"A mediator of RNA polymerase II transcription subunit 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q925J9-3 or a 1:1 ortholog thereof." [PMID:16141072, PRO:HJD]


organism-sequence



PR:Q15648-3

mediator of RNA polymerase II transcription subunit 1 isoform 2 (human)

hMED1/iso:2


"A mediator of RNA polymerase II transcription subunit 1 isoform 3 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q925J9-3

mediator of RNA polymerase II transcription subunit 1 isoform 3 (mouse)

mMED1/iso:3


"A mediator of RNA polymerase II transcription subunit 1 isoform 3 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]


sequence



PR:000028926

mediator of RNA polymerase II transcription subunit 1 isoform 4

MED1/iso:4


"A mediator of RNA polymerase II transcription subunit 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q925J9-4 or a 1:1 ortholog thereof." [PMID:11471062, PRO:HJD]


organism-sequence



PR:Q925J9-4

mediator of RNA polymerase II transcription subunit 1 isoform 4 (mouse)

mMED1/iso:4


"A mediator of RNA polymerase II transcription subunit 1 isoform 4 that is encoded in the genome of mouse." [PMID:11471062, PRO:HJD]


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MED1 forms found in complexes   

MED1 Component
Complexes
PR:Q925J9ZDASHZ1 mMED1/iso:1 PR:000028902 mediator complex, MED26-containing (mouse)
PR:000028957 mediator complex, CDK8-containing (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q925J9-1 mMED1/iso:1 located_inGO:0016592 mediator complex MGI_ref:4462751; PMID:20508642