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Protein Ontology report - E3 ubiquitin-protein ligase Mdm2
PR:000010267 - http://purl.obolibrary.org/obo/PR_000010267
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000010267   
  PRO nameE3 ubiquitin-protein ligase Mdm2 
  Synonyms
PRO-Short-label: EXACT:MDM2
Other: EXACT:double minute 2 protein | hdm2 | oncoprotein Mdm2 | p53-binding protein Mdm2 | RING-type E3 ubiquitin transferase Mdm2
  Definition"A protein that is a translation product of the human MDM2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 13                                        
         Modification0                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010267

E3 ubiquitin-protein ligase Mdm2

MDM2


"A protein that is a translation product of the human MDM2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O42354

E3 ubiquitin-protein ligase Mdm2 (zebrafish)

z-MDM2


"An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of zebrafish." [PRO:DNx]


organism-gene



PR:P23804

E3 ubiquitin-protein ligase Mdm2 (mouse)

mMDM2


"An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of mouse." [OMA:P23804, PRO:DNx]


organism-sequence



PR:P23804-1

E3 ubiquitin-protein ligase Mdm2 isoform 1 (mouse)

mMDM2/iso:1


"An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of mouse." [PMID:2026149, PRO:HJD]


organism-sequence



PR:P23804-2

E3 ubiquitin-protein ligase Mdm2 isoform 2 (mouse)

mMDM2/iso:2


"An E3 ubiquitin-protein ligase Mdm2 isoform 2 that is encoded in the genome of mouse." [PMID:10075719, PRO:HJD]


organism-modification



PR:000046153

E3 ubiquitin-protein ligase Mdm2 phosphorylated 1 (mouse)

mMDM2/Phos:1


"An E3 ubiquitin-protein ligase Mdm2 (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-216 of the amino acid sequence represented by UniProtKB:P23804-1. Example: UniProtKB:P23804-1, Thr-216, MOD:00047." [iPTMnet:P23804, PMID:11359766]


organism-gene



PR:Q00987

E3 ubiquitin-protein ligase Mdm2 (human)

hMDM2


"An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-1

E3 ubiquitin-protein ligase Mdm2 isoform Mdm2 (human)

hMDM2/iso:Mdm2


"An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q00987-10

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-G (human)

hMDM2/iso:hMdm2-G


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-10." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-11

E3 ubiquitin-protein ligase Mdm2 isoform h11 (human)

hMDM2/iso:h11


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-11." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-2

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A (human)

hMDM2/iso:hMdm2-A


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-2." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-3

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A1 (human)

hMDM2/iso:hMdm2-A1


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-3." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-4

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-B (human)

hMDM2/iso:hMdm2-B


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-4." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-5

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-C (human)

hMDM2/iso:hMdm2-C


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-5." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-6

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-D (human)

hMDM2/iso:hMdm2-D


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-6." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-7

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-E (human)

hMDM2/iso:hMdm2-E


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-7." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-8

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-alpha (human)

hMDM2/iso:hMdm2-alpha


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-8." [PRO:DNx, UniProtKB:Q00987]


organism-sequence



PR:Q00987-9

E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-F (human)

hMDM2/iso:hMdm2-F


"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-9." [PRO:DNx, UniProtKB:Q00987]


organism-modification



PR:000045866

E3 ubiquitin-protein ligase Mdm2 phosphorylated 1 (human)

hMDM2/Phos:1


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Tyr-394, MOD:00048." [iPTMnet:Q00987, PMID:12110584]


organism-modification



PR:000048357

E3 ubiquitin-protein ligase Mdm2 phosphorylated 2 (human)

hMDM2/Phos:2


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046." [PRO:DNx, Reactome:R-HSA-198638, Reactome:R-HSA-6793669]


organism-modification



PR:000048358

E3 ubiquitin-protein ligase Mdm2 phosphorylated 3 (human)

hMDM2/Phos:3


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188, and phosphothreonine at position 218 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046|Thr-218, MOD:00047." [PRO:DNx, Reactome:R-HSA-6792862]


organism-modification



PR:000048359

E3 ubiquitin-protein ligase Mdm2 phosphorylated 4 (human)

hMDM2/Phos:4


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166, 188, 386, 395 and 407, and phosphothreonine at position 419 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188/Ser-386/Ser-395/Ser-407, MOD:00046|Thr-419, MOD:00047." [PRO:DNx, Reactome:R-HSA-6804954]


organism-modification



PR:000048360

E3 ubiquitin-protein ligase Mdm2 ubiquitinated form (human)

hMDM2/UbiqLys+


"An E3 ubiquitin-protein ligase Mdm2 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q00987, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782472]


organism-modification



PR:000064768

E3 ubiquitin-protein ligase Mdm2 phosphorylated and ubiquitinated 1 (human)

hMDM2/PhosUbiq:1


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-166 and Ser-188 of the amino acid sequence represented by UniProtKB:Q00987-1 and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q00987-1, Ser-166/Ser-188, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-6795669]


organism-modification



PR:000056835

E3 ubiquitin-protein ligase Mdm2 N-glycosylated 1 (human)

hMDM2/NGlyco:1


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been N-glycosylated at the residue equivalent to Asn-349 of the amino acid sequence represented by UniProtKB:Q00987-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:Q00987-1, Asn-349, MOD:00160~GNO:G00912UN." [GlyGen:Q00987-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000064645

E3 ubiquitin-protein ligase Mdm2 sumoylated 1 (human)

hMDM2/Sumo:1


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been sumoylated on the residue at the position equivalent to Lys-182 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Lys-182, MOD:01149." [PRO:DNx, Reactome:R-HSA-3000408]


organism-modification



PR:000075214

E3 ubiquitin-protein ligase Mdm2 phosphorylated 5 (human)

hMDM2/Phos:5


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-190 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-190, MOD:00046." [IEDB_epitope:2142541, PRO:DNx]


organism-modification



PR:000079554

E3 ubiquitin-protein ligase Mdm2 phosphorylated 6 (human)

hMDM2/Phos:6


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-188 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-188, MOD:00046." [IEDB_epitope:2142540, PRO:DNx]


organism-modification



PR:000083276

E3 ubiquitin-protein ligase Mdm2 phosphorylated 7 (human)

hMDM2/Phos:7


"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-186 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-186, MOD:00046." [IEDB_epitope:2142539, PRO:DNx]


sequence



PR:000026001

E3 ubiquitin-protein ligase Mdm2 isoform 1

MDM2/iso:1


"An E3 ubiquitin-protein ligase Mdm2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23804-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P23804-1

E3 ubiquitin-protein ligase Mdm2 isoform 1 (mouse)

mMDM2/iso:1


"An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of mouse." [PMID:2026149, PRO:HJD]


organism-sequence



PR:Q00987-1

E3 ubiquitin-protein ligase Mdm2 isoform Mdm2 (human)

hMDM2/iso:Mdm2


"An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000026003

E3 ubiquitin-protein ligase Mdm2 isoform 2

MDM2/iso:2


"An E3 ubiquitin-protein ligase Mdm2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23804-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P23804-2

E3 ubiquitin-protein ligase Mdm2 isoform 2 (mouse)

mMDM2/iso:2


"An E3 ubiquitin-protein ligase Mdm2 isoform 2 that is encoded in the genome of mouse." [PMID:10075719, PRO:HJD]