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Protein Ontology report - mitogen-activated protein kinase kinase kinase 8
PR:000010140 - http://purl.obolibrary.org/obo/PR_000010140
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000010140   
  PRO namemitogen-activated protein kinase kinase kinase 8 
  Synonyms
PRO-Short-label: EXACT:MAP3K8
Gene-based: RELATED:COT | ESTF
Other: EXACT:cancer Osaka thyroid oncogene | proto-oncogene c-Cot | serine/threonine-protein kinase cot | TPL-2 | tumor progression locus 2
  Definition"A protein that is a translation product of the human MAP3K8 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2083
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010140

mitogen-activated protein kinase kinase kinase 8

MAP3K8


"A protein that is a translation product of the human MAP3K8 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P41279

mitogen-activated protein kinase kinase kinase 8 (human)

hMAP3K8


"A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P41279-1

mitogen-activated protein kinase kinase kinase 8 isoform 1 (human)

hMAP3K8/iso:1


"A mitogen-activated protein kinase kinase kinase 8 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P41279-2

mitogen-activated protein kinase kinase kinase 8 isoform h2 (human)

hMAP3K8/iso:h2


"A mitogen-activated protein kinase kinase kinase 8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41279-2." [PRO:DNx, UniProtKB:P41279]


organism-modification



PR:000045777

mitogen-activated protein kinase kinase kinase 8 phosphorylated 1 (human)

hMAP3K8/Phos:1


"A mitogen-activated protein kinase kinase kinase 8 (human) that has been phosphorylated on the residue at the position equivalent to Thr-290 of the amino acid sequence represented by UniProtKB:P41279-1. Example: UniProtKB:P41279-1, Thr-290, MOD:00047." [iPTMnet:P41279, PMID:15466476, PMID:15699325]


organism-modification



PR:000048311

mitogen-activated protein kinase kinase kinase 8 phosphorylated 2 (human)

hMAP3K8/Phos:2


"A mitogen-activated protein kinase kinase kinase 8 (human) that has been phosphorylated on the residue at the position equivalent to Thr-290, and phosphoserine at position 400 of the amino acid sequence represented by UniProtKB:P41279. UniProtKB:P41279, Thr-290, MOD:00047|Ser-400, MOD:00046." [PRO:DNx, Reactome:R-HSA-5684259]


organism-modification



PR:000062345

mitogen-activated protein kinase kinase kinase 8 phosphorylated 3 (human)

hMAP3K8/Phos:3


"A mitogen-activated protein kinase kinase kinase 8 (human) that has been phosphorylated on the residue at the position equivalent to Ser-400 of the amino acid sequence represented by UniProtKB:P41279-1. Example: UniProtKB:P41279-1, Ser-400, MOD:00046." [PRO:DNx, Reactome:R-HSA-389738]


organism-gene



PR:Q07174

mitogen-activated protein kinase kinase kinase 8 (mouse)

mMAP3K8


"A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of mouse." [OMA:Q07174, PRO:DNx]


organism-sequence



PR:Q07174-1

mitogen-activated protein kinase kinase kinase 8 isoform 1 (mouse)

mMAP3K8/iso:1


"A mitogen-activated protein kinase kinase kinase 8 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q63562

mitogen-activated protein kinase kinase kinase 8 (rat)

rMAP3K8


"A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of rat." [OMA:Q63562, PRO:DNx]


sequence



PR:000039424

mitogen-activated protein kinase kinase kinase 8 isoform 1

MAP3K8/iso:1


"A mitogen-activated protein kinase kinase kinase 8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41279-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P41279-1

mitogen-activated protein kinase kinase kinase 8 isoform 1 (human)

hMAP3K8/iso:1


"A mitogen-activated protein kinase kinase kinase 8 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q07174-1

mitogen-activated protein kinase kinase kinase 8 isoform 1 (mouse)

mMAP3K8/iso:1


"A mitogen-activated protein kinase kinase kinase 8 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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MAP3K8 forms found in complexes   

MAP3K8 Component
Complexes
PR:P41279 hMAP3K8 PR:000028444 NFKB p105:TPL2:ABIN2 (human)