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Protein Ontology report - dual specificity mitogen-activated protein kinase kinase 2
PR:000010126 - http://purl.obolibrary.org/obo/PR_000010126
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000010126   
  PRO namedual specificity mitogen-activated protein kinase kinase 2 
  Synonyms
PRO-Short-label: EXACT:MAP2K2
Gene-based: RELATED:MEK2 | MKK2 | PRKMK2
Other: EXACT:ERK activator kinase 2 | MAP kinase kinase 2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK 2
  Definition"A protein that is a translation product of the human MAP2K2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2063
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000010126

dual specificity mitogen-activated protein kinase kinase 2

MAP2K2


"A protein that is a translation product of the human MAP2K2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P36506

dual specificity mitogen-activated protein kinase kinase 2 (rat)

rMAP2K2


"A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of rat." [OMA:P36506, PRO:DNx]


organism-sequence



PR:P36506-1

dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (rat)

rMAP2K2/iso:1


"A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P36507

dual specificity mitogen-activated protein kinase kinase 2 (human)

hMAP2K2


"A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P36507]


organism-sequence



PR:000060373

dual specificity mitogen-activated protein kinase kinase 2 sequence variant V35M (human)

hMAP2K2/var:V35M


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Met residue at the position equivalent to Val-35 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Val-35, CHEBI:16044." [PRO:DNx, Reactome:R-HSA-9652086]


organism-sequence



PR:000060463

dual specificity mitogen-activated protein kinase kinase 2 sequence variant F57C (human)

hMAP2K2/var:F57C


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Cys residue at the position equivalent to Phe-57 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Phe-57, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9652073]


organism-sequence



PR:000060542

dual specificity mitogen-activated protein kinase kinase 2 sequence variant C125S (human)

hMAP2K2/var:C125S


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Ser residue at the position equivalent to Cys-125 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Cys-125, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9652070]


organism-sequence



PR:000060802

dual specificity mitogen-activated protein kinase kinase 2 sequence variant P128Q (human)

hMAP2K2/var:P128Q


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Gln residue at the position equivalent to Pro-128 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Pro-128, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-9652082]


organism-sequence



PR:000061456

dual specificity mitogen-activated protein kinase kinase 2 sequence variant N126D (human)

hMAP2K2/var:N126D


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has an Asp residue at the position equivalent to Asn-126 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Asn-126, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-9652079]


organism-sequence



PR:000063141

dual specificity mitogen-activated protein kinase kinase 2 sequence variant Y134C (human)

hMAP2K2/var:Y134C


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Cys residue at the position equivalent to Tyr-134 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Tyr-134, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9652089]


organism-sequence



PR:000063413

dual specificity mitogen-activated protein kinase kinase 2 sequence variant L46F (human)

hMAP2K2/var:L46F


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has a Phe residue at the position equivalent to Leu-46 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Leu-46, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-9652076]


organism-sequence



PR:P36507-1

dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (human)

hMAP2K2/iso:1


"A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000027057

dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form (human)

hMAP2K2/Phos:auto


"A dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form in human." [PMID:8388392]

Yes

organism-modification



PR:000061003

dual specificity mitogen-activated protein kinase kinase 2 phosphoserine and phosphothreonine form (human)

hMAP2K2/pSerThr+


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P36507, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-109848]


organism-modification



PR:000048296

dual specificity mitogen-activated protein kinase kinase 2 phosphorylated 2 (human)

hMAP2K2/Phos:2


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has been post-translationally modified to include phosphoserine at positions 222 and 226 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Ser-222/Ser-226, MOD:00046." [PRO:DNx, Reactome:R-HSA-169292]


organism-modification



PR:000079434

dual specificity mitogen-activated protein kinase kinase 2 methylated 1 (human)

hMAP2K2/Me:1


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that has been methylated on the residue at the position equivalent to Cys-384 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Cys-384, MOD:00660." [IEDB_epitope:1010983, PRO:DNx]


organism-gene



PR:Q63932

dual specificity mitogen-activated protein kinase kinase 2 (mouse)

mMAP2K2


"A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of mouse." [OMA:Q63932, PRO:DNx]


organism-gene



PR:Q90891

dual specificity mitogen-activated protein kinase kinase 2 (chicken)

chick-MAP2K2


"A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of chicken." [OMA:Q90891, PRO:DNx]


sequence



PR:000039362

dual specificity mitogen-activated protein kinase kinase 2 isoform 1

MAP2K2/iso:1


"A dual specificity mitogen-activated protein kinase kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36507-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P36506-1

dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (rat)

rMAP2K2/iso:1


"A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P36507-1

dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (human)

hMAP2K2/iso:1


"A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


modification



PR:000027056

dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form

MAP2K2/Phos:auto


"A dual specificity mitogen-activated protein kinase kinase 2 that has been post-translationally modified to include phosphorylated Ser and Thr residues by autocatalysis." [PMID:8388392]


organism-modification



PR:000027057

dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form (human)

hMAP2K2/Phos:auto


"A dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form in human." [PMID:8388392]

Yes

organism-modification



PR:000061003

dual specificity mitogen-activated protein kinase kinase 2 phosphoserine and phosphothreonine form (human)

hMAP2K2/pSerThr+


"A dual specificity mitogen-activated protein kinase kinase 2 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P36507, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-109848]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027057 hMAP2K2/Phos:auto enablesGO:0004674 protein serine/threonine kinase activity PMID:8388392
located_inGO:0005829 cytosol Reactome:REACT_3571