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Protein Ontology report - inner centromere protein
PR:000009029 - http://purl.obolibrary.org/obo/PR_000009029
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000009029   
  PRO nameinner centromere protein 
  Synonyms
PRO-Short-label: EXACT:INCENP
  Definition"A protein that is a translation product of the human INCENP gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000009029

inner centromere protein

INCENP


"A protein that is a translation product of the human INCENP gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P53352

inner centromere protein (chicken)

chick-INCENP


"An inner centromere protein that is encoded in the genome of chicken." [PRO:DNx]


organism-sequence



PR:P53352-1

inner centromere protein isoform INCENP II (chicken)

chick-INCENP/iso:INCENP II


"An inner centromere protein (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P53352-1." [PRO:DNx, UniProtKB:P53352]


organism-sequence



PR:P53352-2

inner centromere protein isoform INCENP I (chicken)

chick-INCENP/iso:INCENP I


"An inner centromere protein (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P53352-2." [PRO:DNx, UniProtKB:P53352]


organism-gene



PR:Q9NQS7

inner centromere protein (human)

hINCENP


"An inner centromere protein that is encoded in the genome of human." [PRO:KER]

Yes

organism-sequence



PR:Q9NQS7-1

inner centromere protein isoform h1 (human)

hINCENP/iso:h1


"An inner centromere protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQS7-1." [PRO:DNx, UniProtKB:Q9NQS7]


organism-sequence



PR:Q9NQS7-2

inner centromere protein isoform h2 (human)

hINCENP/iso:h2


"An inner centromere protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NQS7-2." [PRO:DNx, UniProtKB:Q9NQS7]


organism-modification



PR:000035527

inner centromere protein phosphorylated 1 (human)

hINCENP/Phos:1


"An inner centromere protein phosphorylated 1 in human. UniProtKB:Q9NQS7, Thr-892, MOD:00047|Ser-893/Ser-894, MOD:00046." [PMID:12925766, PMID:27332895, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000035529

inner centromere protein unphosphorylated form (human)

hINCENP/PhosRes-


"An inner centromere protein unphosphorylated form in human." [PRO:KER]


organism-modification



PR:000070978

inner centromere protein methylated 1 (human)

hINCENP/Me:1


"An inner centromere protein (human) that has been methylated on the residue at the position equivalent to Cys-801 of the amino acid sequence represented by UniProtKB:Q9NQS7-1. Example: UniProtKB:Q9NQS7-1, Cys-801, MOD:00660." [IEDB_epitope:1059095, PRO:DNx]


organism-modification



PR:000080314

inner centromere protein phosphorylated 2 (human)

hINCENP/Phos:2


"An inner centromere protein (human) that has been phosphorylated on the residue at the position equivalent to Ser-50 of the amino acid sequence represented by UniProtKB:Q9NQS7-1. Example: UniProtKB:Q9NQS7-1, Ser-50, MOD:00046." [IEDB_epitope:610784, PRO:DNx]


organism-modification



PR:000083136

inner centromere protein cysteinylated 1 (human)

hINCENP/Cyst:1


"An inner centromere protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-801 of the amino acid sequence represented by UniProtKB:Q9NQS7-1. Example: UniProtKB:Q9NQS7-1, Cys-801, MOD:00765." [IEDB_epitope:1059094, PRO:DNx]


organism-gene



PR:Q9WU62

inner centromere protein (mouse)

mINCENP


"An inner centromere protein that is encoded in the genome of mouse." [OMA:Q9WU62, PRO:DNx]


organism-sequence



PR:Q9WU62-1

inner centromere protein isoform m1 (mouse)

mINCENP/iso:m1


"An inner centromere protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WU62-1." [PRO:DNx, UniProtKB:Q9WU62]


organism-sequence



PR:Q9WU62-2

inner centromere protein isoform m2 (mouse)

mINCENP/iso:m2


"An inner centromere protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WU62-2." [PRO:DNx, UniProtKB:Q9WU62]


modification



PR:000035526

inner centromere protein phosphorylated 1

INCENP/Phos:1


"An inner centromere protein that has been phosphorylated on the Thr residue and the Ser residues in the TSS motif. Example: UniProtKB:Q9NQS7, Thr-892, MOD:00047|Ser-893/Ser-894, MOD:00046." [PMID:22024163, PRO:KER]


organism-modification



PR:000035527

inner centromere protein phosphorylated 1 (human)

hINCENP/Phos:1


"An inner centromere protein phosphorylated 1 in human. UniProtKB:Q9NQS7, Thr-892, MOD:00047|Ser-893/Ser-894, MOD:00046." [PMID:12925766, PMID:27332895, PRO:DAN, PRO:KER]

Yes

modification



PR:000035528

inner centromere protein unphosphorylated form

INCENP/PhosRes-


"An inner centromere protein that lacks phosphorylated residues." [PRO:KER]


organism-modification



PR:000035529

inner centromere protein unphosphorylated form (human)

hINCENP/PhosRes-


"An inner centromere protein unphosphorylated form in human." [PRO:KER]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035527 hINCENP/Phos:1
UniProtKB:Q9NQS7, Thr-892, MOD:00047|Ser-893/Ser-894, MOD:00046
acts_upstream_of_or_withinincreased GO:0033674 positive regulation of kinase activity relative to PR:000035529 hINCENP/PhosRes- PMID:22024163
PR:Q9NQS7 hINCENP acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:17617734
GO:0034501 protein localization to kinetochore PMID:17617734
enablesGO:0005515 protein binding with PR:O15392 API4 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P06493 CDC2 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q53HL2 CDCA8 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q5FBB7 hSGO1 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human) BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q96GD4 AIK2 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
located_inGO:0000776 kinetochore PMID:20624902
GO:0000939 inner kinetochore PMID:16760428