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Protein Ontology report - glutamate--cysteine ligase catalytic subunit
PR:000007897 - http://purl.obolibrary.org/obo/PR_000007897
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000007897   
  PRO nameglutamate--cysteine ligase catalytic subunit 
  Synonyms
PRO-Short-label: EXACT:GCLC
Gene-based: RELATED:GLCL | GLCLC
Other: EXACT:GCS heavy chain
RELATED:gamma-ECS | gamma-glutamylcysteine synthetase
  Definition"A protein that is a translation product of the human GCLC gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 9                                        
         Sequence1                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000007897

glutamate--cysteine ligase catalytic subunit

GCLC


"A protein that is a translation product of the human GCLC gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P19468

glutamate--cysteine ligase catalytic subunit (rat)

rGCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of rat." [OMA:P19468, PRO:DNx]


organism-sequence



PR:P19468-1

glutamate--cysteine ligase catalytic subunit isoform 1 (rat)

rGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P32477

glutamate--cysteine ligase (yeast)

yGCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of yeast." [OMA:P32477, PRO:DNx]


organism-gene



PR:P48506

glutamate--cysteine ligase catalytic subunit (human)

hGCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:000060326

glutamate--cysteine ligase catalytic subunit sequence variant R127C (human)

hGCLC/var:R127C


"A glutamate--cysteine ligase catalytic subunit (human) that has a Cys residue at the position equivalent to Arg-127 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Arg-127, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5602822]


organism-sequence



PR:000061222

glutamate--cysteine ligase catalytic subunit sequence variant H370L (human)

hGCLC/var:H370L


"A glutamate--cysteine ligase catalytic subunit (human) that has a Leu residue at the position equivalent to His-370 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, His-370, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-5602842]


organism-sequence



PR:000062472

glutamate--cysteine ligase catalytic subunit sequence variant P158L (human)

hGCLC/var:P158L


"A glutamate--cysteine ligase catalytic subunit (human) that has a Leu residue at the position equivalent to Pro-158 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Pro-158, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-5602975]


organism-sequence



PR:P48506-1

glutamate--cysteine ligase catalytic subunit isoform 1 (human)

hGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000073811

glutamate--cysteine ligase catalytic subunit methylated 1 (human)

hGCLC/Me:1


"A glutamate--cysteine ligase catalytic subunit (human) that has been methylated on the residue at the position equivalent to Cys-273 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Cys-273, MOD:00660." [IEDB_epitope:1032586, PRO:DNx]


organism-gene



PR:P97494

glutamate--cysteine ligase catalytic subunit (mouse)

mGCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of mouse." [OMA:P97494, PRO:DNx]


organism-sequence



PR:P97494-1

glutamate--cysteine ligase catalytic subunit isoform 1 (mouse)

mGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q09768

glutamate--cysteine ligase (Schizosaccharomyces pombe 972h-)

Spom972h-GCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09768, PRO:DNx]


organism-gene



PR:Q20117

glutamate--cysteine ligase (worm)

GCLC (worm)


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of worm." [OMA:Q20117, PRO:DNx]


organism-gene



PR:Q54PC2

glutamate--cysteine ligase (Dictyostelium discoideum)

Dicty-GCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54PC2, PRO:DNx]


organism-gene



PR:Q9NFN6

glutamate--cysteine ligase (Onchocerca volvulus)

GCLC (ONCVO)


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of Onchocerca volvulus." [OMA:Q9NFN6, PRO:DNx]


organism-gene



PR:Q9W3K5

glutamate--cysteine ligase (fruit fly)

fly-GCLC


"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of fruit fly." [OMA:Q9W3K5, PRO:DNx]


sequence



PR:000039544

glutamate--cysteine ligase catalytic subunit isoform 1

GCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48506-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P19468-1

glutamate--cysteine ligase catalytic subunit isoform 1 (rat)

rGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P48506-1

glutamate--cysteine ligase catalytic subunit isoform 1 (human)

hGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P97494-1

glutamate--cysteine ligase catalytic subunit isoform 1 (mouse)

mGCLC/iso:1


"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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GCLC forms found in complexes   

GCLC Component
Complexes
PR:P48506 hGCLC PR:000027406 glutamate-cysteine ligase complex (human)