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Protein Ontology report - receptor tyrosine-protein kinase erbB-4
PR:000007160 - http://purl.obolibrary.org/obo/PR_000007160
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000007160   
  PRO namereceptor tyrosine-protein kinase erbB-4 
  Synonyms
PRO-Short-label: EXACT:ERBB4
Gene-based: RELATED:HER4 | Mer4
Other: EXACT:p180erbB4 | proto-oncogene-like protein c-ErbB-4 | tyrosine kinase-type cell surface receptor HER4
  Definition"An EGF receptor type tyrosine-protein kinase that is a translation product of the human ERBB4 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000001812 EGF receptor type tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1799
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000007160

receptor tyrosine-protein kinase erbB-4

ERBB4


"An EGF receptor type tyrosine-protein kinase that is a translation product of the human ERBB4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q15303

receptor tyrosine-protein kinase erbB-4 (human)

hERBB4


"A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15303]


organism-sequence



PR:Q15303-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human)

hERBB4/iso:JM-A CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000060776

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1, signal peptide removed form (human)

hERBB4/iso:JM-A CYT-1/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human) that has had the signal peptide removed. UniProtKB:Q15303-1, 26-1308." [PRO:DNx, Reactome:R-HSA-1227940]


organism-modification



PR:000062087

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-A CYT-1/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1056, Tyr-1188, and Tyr-1242 of the amino acid sequence represented by UniProtKB:Q15303-1. UniProtKB:Q15303-1, 26-1308, Tyr-1056/Tyr-1188/Tyr-1242, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250319]


organism-sequence



PR:Q15303-2

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human)

hERBB4/iso:JM-B CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000061332

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1, signal peptide removed form (human)

hERBB4/iso:JM-B CYT-1/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human) that has had the signal peptide removed. UniProtKB:Q15303-2, 26-1298." [PRO:DNx, Reactome:R-HSA-1233232]


organism-modification



PR:000064545

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-B CYT-1/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1046, Tyr-1178, and Tyr-1232 of the amino acid sequence represented by UniProtKB:Q15303-2. UniProtKB:Q15303-2, 26-1298, Tyr-1046/Tyr-1178/Tyr-1232, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250313]


organism-sequence



PR:Q15303-3

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human)

hERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000063649

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2, signal peptide removed form (human)

hERBB4/iso:JM-A CYT-2/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human) that has had the signal peptide removed. UniProtKB:Q15303-3, 26-1292." [PRO:DNx, Reactome:R-HSA-1233237]


organism-modification



PR:000060565

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-A CYT-2/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1172 and Tyr-1226 of the amino acid sequence represented by UniProtKB:Q15303-3. UniProtKB:Q15303-3, 26-1292, Tyr-1172/Tyr-1226, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250307]


organism-sequence



PR:Q15303-4

receptor tyrosine-protein kinase erbB-4 isoform hJM-B CYT-2 (human)

hERBB4/iso:hJM-B CYT-2


"A receptor tyrosine-protein kinase erbB-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15303-4." [PRO:DNx, UniProtKB:Q15303]


organism-modification



PR:000045942

receptor tyrosine-protein kinase erbB-4 phosphorylated 1 (human)

hERBB4/Phos:1


"A receptor tyrosine-protein kinase erbB-4 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1056 of the amino acid sequence represented by UniProtKB:Q15303-1. Example: UniProtKB:Q15303-1, Tyr-1056, MOD:00048." [iPTMnet:Q15303, PMID:16934755, PMID:17120616]


organism-gene



PR:Q61527

receptor tyrosine-protein kinase erbB-4 (mouse)

mERBB4


"A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of mouse." [OMA:Q61527, PRO:DNx]

Yes

organism-sequence



PR:Q61527-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (mouse)

mERBB4/iso:JM-A CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q61527-2

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-2 (mouse)

mERBB4/iso:JM-B CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q61527-3

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (mouse)

mERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000044846

receptor tyrosine-protein kinase erbB-4 phosphotyrosine form (mouse)

mERBB4/PhosTyr+


"A receptor tyrosine-protein kinase erbB-4 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:Q61527, MOD:00048." [PMID:21186272, PRO:KRC]


organism-gene



PR:Q62956

receptor tyrosine-protein kinase erbB-4 (rat)

rERBB4


"A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q62956-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT1 (rat)

rERBB4/iso:JM-A CYT1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q62956-2

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT2 (rat)

rERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000040615

receptor tyrosine-protein kinase erbB-4 isoform 1

ERBB4/iso:1


"A receptor tyrosine-protein kinase erbB-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15303-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q15303-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human)

hERBB4/iso:JM-A CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000060776

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1, signal peptide removed form (human)

hERBB4/iso:JM-A CYT-1/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human) that has had the signal peptide removed. UniProtKB:Q15303-1, 26-1308." [PRO:DNx, Reactome:R-HSA-1227940]


organism-modification



PR:000062087

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-A CYT-1/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1056, Tyr-1188, and Tyr-1242 of the amino acid sequence represented by UniProtKB:Q15303-1. UniProtKB:Q15303-1, 26-1308, Tyr-1056/Tyr-1188/Tyr-1242, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250319]


organism-sequence



PR:Q61527-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (mouse)

mERBB4/iso:JM-A CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q62956-1

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT1 (rat)

rERBB4/iso:JM-A CYT1


"A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000040616

receptor tyrosine-protein kinase erbB-4 isoform 2

ERBB4/iso:2


"A receptor tyrosine-protein kinase erbB-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15303-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q15303-2

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human)

hERBB4/iso:JM-B CYT-1


"A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000061332

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1, signal peptide removed form (human)

hERBB4/iso:JM-B CYT-1/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human) that has had the signal peptide removed. UniProtKB:Q15303-2, 26-1298." [PRO:DNx, Reactome:R-HSA-1233232]


organism-modification



PR:000064545

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-B CYT-1/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-1 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1046, Tyr-1178, and Tyr-1232 of the amino acid sequence represented by UniProtKB:Q15303-2. UniProtKB:Q15303-2, 26-1298, Tyr-1046/Tyr-1178/Tyr-1232, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250313]


organism-sequence



PR:Q61527-2

receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-2 (mouse)

mERBB4/iso:JM-B CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000040617

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2

ERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15303-3 or a 1:1 ortholog thereof." [PRO:DAN]


organism-sequence



PR:Q15303-3

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human)

hERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000063649

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2, signal peptide removed form (human)

hERBB4/iso:JM-A CYT-2/SigPep-


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human) that has had the signal peptide removed. UniProtKB:Q15303-3, 26-1292." [PRO:DNx, Reactome:R-HSA-1233237]


organism-modification



PR:000060565

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2, signal peptide removed phosphorylated 1 (human)

hERBB4/iso:JM-A CYT-2/SigPep-/Phos:1


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1172 and Tyr-1226 of the amino acid sequence represented by UniProtKB:Q15303-3. UniProtKB:Q15303-3, 26-1292, Tyr-1172/Tyr-1226, MOD:00048." [PRO:DNx, Reactome:R-HSA-1250307]


organism-sequence



PR:Q61527-3

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 (mouse)

mERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q62956-2

receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT2 (rat)

rERBB4/iso:JM-A CYT-2


"A receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-2 that is encoded in the genome of rat." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q61527 mERBB4 acts_upstream_of_or_withinGO:2001223 negative regulation of neuron migration MGI_ref:5320808; PMID:22376909