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Protein Ontology report - bifunctional glutamate/proline--tRNA ligase
PR:000007144 - http://purl.obolibrary.org/obo/PR_000007144
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000007144   
  PRO namebifunctional glutamate/proline--tRNA ligase 
  Synonyms
PRO-Short-label: EXACT:EPRS1
Gene-based: RELATED:EPRS | GLNS | PARS | PIG32 | QARS | QPRS
Other: EXACT:cell proliferation-inducing gene 32 protein
RELATED:bifunctional aminoacyl-tRNA synthetase
  Definition"A protein that is a translation product of the human EPRS1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000007144

bifunctional glutamate/proline--tRNA ligase

EPRS1


"A protein that is a translation product of the human EPRS1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P07814

bifunctional glutamate/proline--tRNA ligase (human)

hEPRS1


"A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P07814-1

bifunctional glutamate/proline--tRNA ligase isoform 1 (human)

hEPRS/iso:1


"A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000037787

bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (human)

hEPRS/Phos:1


"A bifunctional glutamate/proline--tRNA ligase (human) that has been phosphorylated on two Ser residues in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. The first site conforms to the motif [ST]Px[KR]. UniProtKB:P07814, Ser-886/Ser-999, MOD:00046." [PMID:19647514, PRO:CNA]


organism-modification



PR:000037788

bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (human)

hEPRS/UnPhos:1


"A bifunctional glutamate/proline--tRNA ligase (human) that lacks phosphorylation on residues equivalent to Ser-886 and Ser-999 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Ser-886/Ser-999, PR:000026291." [PMID:19647514, PRO:CNA]


organism-modification



PR:000065327

bifunctional glutamate/proline--tRNA ligase methylated 1 (human)

hEPRS1/Me:1


"A bifunctional glutamate/proline--tRNA ligase (human) that has been methylated on the residue at the position equivalent to Cys-697 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Cys-697, MOD:00660." [IEDB_epitope:1023372, PRO:DNx]


organism-modification



PR:000067109

bifunctional glutamate/proline--tRNA ligase methylated 2 (human)

hEPRS1/Me:2


"A bifunctional glutamate/proline--tRNA ligase (human) that has been methylated on the residue at the position equivalent to Cys-1046 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Cys-1046, MOD:00660." [IEDB_epitope:1004420, IEDB_epitope:1061272, PRO:DNx]


organism-modification



PR:000068607

bifunctional glutamate/proline--tRNA ligase phosphorylated 2 (human)

hEPRS1/Phos:2


"A bifunctional glutamate/proline--tRNA ligase (human) that has been phosphorylated on the residue at the position equivalent to Tyr-57 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Tyr-57, MOD:00048." [IEDB_epitope:2148238, PRO:DNx]


organism-modification



PR:000071309

bifunctional glutamate/proline--tRNA ligase deaminated 1 (human)

hEPRS1/Deam:1


"A bifunctional glutamate/proline--tRNA ligase (human) that has been deaminated on the residue at the position equivalent to Asn-52 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Asn-52, MOD:00684." [IEDB_epitope:430205, PRO:DNx]


organism-modification



PR:000072996

bifunctional glutamate/proline--tRNA ligase methylated 3 (human)

hEPRS1/Me:3


"A bifunctional glutamate/proline--tRNA ligase (human) that has been methylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Cys-105, MOD:00660." [IEDB_epitope:1035372, IEDB_epitope:1054260, PRO:DNx]


organism-modification



PR:000075361

bifunctional glutamate/proline--tRNA ligase cysteinylated 1 (human)

hEPRS1/Cyst:1


"A bifunctional glutamate/proline--tRNA ligase (human) that has been cysteinylated on the residue at the position equivalent to Cys-623 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Cys-623, MOD:00765." [IEDB_epitope:1337248, PRO:DNx]


organism-modification



PR:000075729

bifunctional glutamate/proline--tRNA ligase deaminated 2 (human)

hEPRS1/Deam:2


"A bifunctional glutamate/proline--tRNA ligase (human) that has been deaminated on the residue at the position equivalent to Gln-1188 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Gln-1188, MOD:00685." [IEDB_epitope:1976488, PRO:DNx]


organism-modification



PR:000078261

bifunctional glutamate/proline--tRNA ligase methylated 4 (human)

hEPRS1/Me:4


"A bifunctional glutamate/proline--tRNA ligase (human) that has been methylated on the residue at the position equivalent to Met-277 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Met-277, MOD:00716." [IEDB_epitope:432187, PRO:DNx]


organism-modification



PR:000083424

bifunctional glutamate/proline--tRNA ligase deaminated 3 (human)

hEPRS1/Deam:3


"A bifunctional glutamate/proline--tRNA ligase (human) that has been deaminated on the residue at the position equivalent to Gln-135 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Gln-135, MOD:00685." [IEDB_epitope:1983905, PRO:DNx]


organism-gene



PR:P28668

bifunctional glutamate/proline--tRNA ligase (fruit fly)

fly-EPRS1


"A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of fruit fly." [OMA:P28668, PRO:DNx]


organism-sequence



PR:P28668-1

bifunctional glutamate/proline--tRNA ligase isoform A (fruit fly)

fly-EPRS1/iso:A


"A bifunctional glutamate/proline--tRNA ligase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28668-1." [PRO:DNx, UniProtKB:P28668]


organism-sequence



PR:P28668-2

bifunctional glutamate/proline--tRNA ligase isoform B (fruit fly)

fly-EPRS1/iso:B


"A bifunctional glutamate/proline--tRNA ligase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28668-2." [PRO:DNx, UniProtKB:P28668]


organism-gene



PR:Q23315

ZC434.5 (worm)

EPRS (worm)


"A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of worm." [PANTHER:PTHR10119:SF11, PRO:DNx]


organism-gene



PR:Q8CGC7

bifunctional glutamate/proline--tRNA ligase (mouse)

mEPRS


"A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of mouse." [OMA:Q8CGC7, PMID:15489334, PRO:HJD]


organism-sequence



PR:Q8CGC7-1

bifunctional glutamate/proline--tRNA ligase isoform 1 (mouse)

mEPRS/iso:1


"A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000037785

bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (mouse)

mEPRS/Phos:1


"A bifunctional glutamate/proline--tRNA ligase (mouse) that has been phosphorylated on a Ser residue in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. UniProtKB:Q8CGC7, Ser-999, MOD:00046." [PMID:23071094, PRO:HJD]

Yes

Yes
organism-modification



PR:000037786

bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (mouse)

mEPRS/UnPhos:1


"A bifunctional glutamate/proline--tRNA ligase (mouse) that lacks phosphorylation at the position equivalent to Ser-999 of the amino acid sequence represented by UniProtKB:Q8CGC7. UniProtKB:Q8CGC7, Ser-999, PR:000026291." [PMID:23071094, PRO:HJD]

Yes

sequence



PR:000038719

bifunctional glutamate/proline--tRNA ligase isoform 1

EPRS/iso:1


"A bifunctional glutamate/proline--tRNA ligase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07814-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P07814-1

bifunctional glutamate/proline--tRNA ligase isoform 1 (human)

hEPRS/iso:1


"A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q8CGC7-1

bifunctional glutamate/proline--tRNA ligase isoform 1 (mouse)

mEPRS/iso:1


"A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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EPRS1 forms found in complexes   

EPRS1 Component
Complexes
PR:000037785 mEPRS/Phos:1 PR:000037795 GAIT complex (mouse)
PR:P07814 hEPRS1 PR:000027407 aminoacyl-tRNA synthetase multienzyme complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037785 mEPRS/Phos:1
UniProtKB:Q8CGC7, Ser-999, MOD:00046
acts_upstream_of_or_withinGO:0071346 cellular response to type II interferon MGI_ref:5466658; PMID:23071094
located_inGO:0097452 GAIT complex MGI_ref:5466658; PMID:23071094
PR:000037786 mEPRS/UnPhos:1
UniProtKB:Q8CGC7, Ser-999, PR:000026291
located_inGO:0017101 aminoacyl-tRNA synthetase multienzyme complex MGI_ref:5466658; PMID:23071094
NOT GO:0097452 GAIT complex MGI_ref:5466658; PMID:23071094