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Protein Ontology report - segment polarity protein dishevelled homolog DVL-2
PR:000006767 - http://purl.obolibrary.org/obo/PR_000006767
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000006767   
  PRO namesegment polarity protein dishevelled homolog DVL-2 
  Synonyms
PRO-Short-label: EXACT:DVL2
Other: EXACT:dishevelled-2 | DSH homolog 2
  Definition"A protein that is a translation product of the human DVL2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000006767

segment polarity protein dishevelled homolog DVL-2

DVL2


"A protein that is a translation product of the human DVL2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O14641

segment polarity protein dishevelled homolog DVL-2 (human)

hDVL2


"A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human." [PMID:20823832, PRO:KER]

Yes

organism-sequence



PR:O14641-1

segment polarity protein dishevelled homolog DVL-2 isoform 1 (human)

hDVL2/iso:1


"A segment polarity protein dishevelled homolog DVL-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000035550

segment polarity protein dishevelled homolog DVL-2 unphosphorylated form (human)

hDVL2/PhosRes-


"A segment polarity protein dishevelled homolog DVL-2 unphosphorylated form in human." [PMID:20823832, PRO:KER]

Yes

organism-modification



PR:000047225

segment polarity protein dishevelled homolog DVL-2 phosphorylated form (human)

hDVL2/PhosRes+


"A segment polarity protein dishevelled homolog DVL-2 (human) that includes at least one phosphorylated residue. UniProtKB:O14641, MOD:00696." [PRO:DNx, Reactome:R-HSA-5138444]


organism-modification



PR:000035549

segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 (human)

hDVL2/Phos:1


"A segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 in human. UniProtKB:O14641, Thr-206, MOD:00047." [PMID:20823832, PRO:KER]

Yes

organism-modification



PR:000047226

segment polarity protein dishevelled homolog DVL-2 ubiquitinated form (human)

hDVL2/UbiqLys+


"A segment polarity protein dishevelled homolog DVL-2 (human) that includes at least one ubiquitinated lysine. UniProtKB:O14641, MOD:01148." [PRO:DNx, Reactome:R-HSA-4652689]


organism-modification



PR:000064079

segment polarity protein dishevelled homolog DVL-2 phosphorylated(2+) form (human)

hDVL2/PhosRes(2+)


"A segment polarity protein dishevelled homolog DVL-2 (human) that includes at least two phosphorylated residues. UniProtKB:O14641, MOD:00696(2+)." [PRO:DNx, Reactome:R-HSA-3772398]


organism-modification



PR:000074434

segment polarity protein dishevelled homolog DVL-2 cysteinylated 1 (human)

hDVL2/Cyst:1


"A segment polarity protein dishevelled homolog DVL-2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-354 of the amino acid sequence represented by UniProtKB:O14641. UniProtKB:O14641, Cys-354, MOD:00765." [IEDB_epitope:1004395, PRO:DNx]


organism-modification



PR:000083432

segment polarity protein dishevelled homolog DVL-2 methylated 1 (human)

hDVL2/Me:1


"A segment polarity protein dishevelled homolog DVL-2 (human) that has been methylated on the residue at the position equivalent to Cys-354 of the amino acid sequence represented by UniProtKB:O14641. UniProtKB:O14641, Cys-354, MOD:00660." [IEDB_epitope:1004396, PRO:DNx]


organism-gene



PR:Q60838

segment polarity protein dishevelled homolog DVL-2 (mouse)

mDVL2


"A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of mouse." [OMA:Q60838, PRO:DNx]


organism-sequence



PR:Q60838-1

segment polarity protein dishevelled homolog DVL-2 isoform 1 (mouse)

mDVL2/iso:1


"A segment polarity protein dishevelled homolog DVL-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000037983

segment polarity protein dishevelled homolog DVL-2 isoform 1

DVL2/iso:1


"A segment polarity protein dishevelled homolog DVL-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14641-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O14641-1

segment polarity protein dishevelled homolog DVL-2 isoform 1 (human)

hDVL2/iso:1


"A segment polarity protein dishevelled homolog DVL-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q60838-1

segment polarity protein dishevelled homolog DVL-2 isoform 1 (mouse)

mDVL2/iso:1


"A segment polarity protein dishevelled homolog DVL-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


modification



PR:000019714

segment polarity protein dishevelled homolog DVL-2, initiator methionine removed form

DVL2/InitMet-


"A segment polarity protein dishevelled homolog DVL-2 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000035547

segment polarity protein dishevelled homolog DVL-2 unphosphorylated form

DVL2/PhosRes-


"A segment polarity protein dishevelled homolog DVL-2 that lacks phosphorylated residues." [PMID:20823832, PRO:KER]


organism-modification



PR:000035550

segment polarity protein dishevelled homolog DVL-2 unphosphorylated form (human)

hDVL2/PhosRes-


"A segment polarity protein dishevelled homolog DVL-2 unphosphorylated form in human." [PMID:20823832, PRO:KER]

Yes

modification



PR:000035548

segment polarity protein dishevelled homolog DVL-2 phosphorylated 1

DVL2/Phos:1


"A segment polarity protein dishevelled homolog DVL-2 that has been phosphorylated on the residue at the position equivalent to Thr-206 of the amino acid sequence represented by UniProtKB:O14641. Example: UniProtKB:O14641, Thr-206, MOD:00047." [PMID:20823832, PRO:KER]


organism-modification



PR:000035549

segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 (human)

hDVL2/Phos:1


"A segment polarity protein dishevelled homolog DVL-2 phosphorylated 1 in human. UniProtKB:O14641, Thr-206, MOD:00047." [PMID:20823832, PRO:KER]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035549 hDVL2/Phos:1
UniProtKB:O14641, Thr-206, MOD:00047
acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:20823832
increased GO:0051294 establishment of spindle orientation relative to PR:000035550 hDVL2/PhosRes- PMID:20823832
PR:000035550 hDVL2/PhosRes- acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:20823832
located_inGO:0000776 kinetochore PMID:20823832
PR:O14641 hDVL2 acts_upstream_of_or_withinGO:0008608 attachment of spindle microtubules to kinetochore PMID:20823832
GO:0031589 cell-substrate adhesion PMID:20823832
GO:0033674 positive regulation of kinase activity PMID:20823832
GO:0034501 protein localization to kinetochore PMID:20823832
GO:0034501 protein localization to kinetochore PMID:20823832
GO:0051310 metaphase chromosome alignment PMID:20823832
enablesGO:0005515 protein binding with PR:P25054 APC PMID:20823832
GO:0005515 protein binding with PR:P33981 hTTK PMID:20823832
GO:0005515 protein binding with PR:P53350 hPLK1 PMID:20823832
located_inGO:0000776 kinetochore PMID:20823832
GO:0000922 spindle pole PMID:20823832
GO:0005819 spindle PMID:20823832
GO:0032154 cleavage furrow PMID:20823832