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Protein Ontology report - catechol O-methyltransferase
PR:000005731 - http://purl.obolibrary.org/obo/PR_000005731
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005731   
  PRO namecatechol O-methyltransferase 
  Synonyms
PRO-Short-label: EXACT:COMT
Gene-based: RELATED:Comt1
  Definition"A protein that is a translation product of the human COMT gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 8                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2472
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000005731

catechol O-methyltransferase

COMT


"A protein that is a translation product of the human COMT gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:F4ZGF2

catechol O-methyltransferase A (zebrafish)

z-COMT


"A catechol O-methyltransferase that is encoded in the genome of zebrafish." [PRO:DNx]


organism-sequence



PR:F4ZGF2-1

catechol O-methyltransferase A isoform 1 (zebrafish)

z-COMT/iso:1


"A catechol O-methyltransferase A (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:F4ZGF2-1." [PRO:DNx, UniProtKB:F4ZGF2]


organism-sequence



PR:F4ZGF2-2

catechol O-methyltransferase A isoform 2 (zebrafish)

z-COMT/iso:2


"A catechol O-methyltransferase A (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:F4ZGF2-2." [PRO:DNx, UniProtKB:F4ZGF2]


organism-gene



PR:O42898

probable catechol O-methyltransferase 1 (Schizosaccharomyces pombe 972h-)

Spom972h-COMT


"A catechol O-methyltransferase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O42898, PRO:DNx]


organism-gene



PR:O88587

catechol O-methyltransferase (mouse)

mCOMT


"A catechol O-methyltransferase that is encoded in the genome of mouse." [OMA:O88587, PRO:DNx]


organism-sequence



PR:O88587-1

catechol O-methyltransferase isoform 1 (mouse)

mCOMT/iso:1


"A catechol O-methyltransferase isoform 1 that is encoded in the genome of mouse." [PMID:20374420, PRO:HJD]

Yes

organism-sequence



PR:O88587-2

catechol O-methyltransferase isoform 2 (mouse)

mCOMT/iso:2


"A catechol O-methyltransferase isoform 2 that is encoded in the genome of mouse." [PMID:20374420, PRO:HJD]

Yes

organism-gene



PR:P21964

catechol O-methyltransferase (human)

hCOMT


"A catechol O-methyltransferase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P21964]


organism-sequence



PR:P21964-1

catechol O-methyltransferase isoform Membrane-bound (human)

hCOMT/iso:Membrane-bound


"A catechol O-methyltransferase isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P21964-2

catechol O-methyltransferase isoform Soluble (human)

hCOMT/iso:Soluble


"A catechol O-methyltransferase isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:P22734

catechol O-methyltransferase (rat)

rCOMT


"A catechol O-methyltransferase that is encoded in the genome of rat." [OMA:P22734, PRO:DNx]


organism-sequence



PR:P22734-1

catechol O-methyltransferase isoform Membrane-bound (rat)

rCOMT/iso:Membrane-bound


"A catechol O-methyltransferase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22734-1." [PRO:DNx, UniProtKB:P22734]


organism-sequence



PR:P22734-2

catechol O-methyltransferase isoform Soluble (rat)

rCOMT/iso:Soluble


"A catechol O-methyltransferase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22734-2." [PRO:DNx, UniProtKB:P22734]


sequence



PR:000025997

catechol O-methyltransferase isoform 1

COMT/iso:1


"A catechol O-methyltransferase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88587-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O88587-1

catechol O-methyltransferase isoform 1 (mouse)

mCOMT/iso:1


"A catechol O-methyltransferase isoform 1 that is encoded in the genome of mouse." [PMID:20374420, PRO:HJD]

Yes

organism-sequence



PR:P21964-1

catechol O-methyltransferase isoform Membrane-bound (human)

hCOMT/iso:Membrane-bound


"A catechol O-methyltransferase isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000025999

catechol O-methyltransferase isoform 2

COMT/iso:2


"A catechol O-methyltransferase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88587-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O88587-2

catechol O-methyltransferase isoform 2 (mouse)

mCOMT/iso:2


"A catechol O-methyltransferase isoform 2 that is encoded in the genome of mouse." [PMID:20374420, PRO:HJD]

Yes

organism-sequence



PR:P21964-2

catechol O-methyltransferase isoform Soluble (human)

hCOMT/iso:Soluble


"A catechol O-methyltransferase isoform 2 that is encoded in the genome of human." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:O88587-1 mCOMT/iso:1 acts_upstream_of_or_withinGO:0042417 dopamine metabolic process MGI_ref:4830461; PMID:19930170
located_inNOT GO:0005886 plasma membrane MGI_ref:4822307; PMID:20374420
PR:O88587-2 mCOMT/iso:2 acts_upstream_of_or_withinGO:0009712 catechol-containing compound metabolic process MGI_ref:4830461; PMID:19930170
GO:0042417 dopamine metabolic process MGI_ref:4830461; PMID:19930170
enablesGO:0016206 catechol O-methyltransferase activity MGI_ref:4830461; PMID:19930170