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Protein Ontology report - cyclin-dependent kinase 8
PR:000005266 - http://purl.obolibrary.org/obo/PR_000005266
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000005266   
  PRO namecyclin-dependent kinase 8 
  Synonyms
PRO-Short-label: EXACT:CDK8
Other: EXACT:cell division protein kinase 8 | mediator complex subunit CDK8 | mediator of RNA polymerase II transcription subunit CDK8 | protein kinase K35
  Definition"A CDK2-related kinase that is a translation product of the human CDK8 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000003270 CDK2-related kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1980
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000005266

cyclin-dependent kinase 8

CDK8


"A CDK2-related kinase that is a translation product of the human CDK8 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P49336

cyclin-dependent kinase 8 (human)

hCDK8


"A cyclin-dependent kinase 8 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49336]


organism-sequence



PR:P49336-1

cyclin-dependent kinase 8 isoform 1 (human)

hCDK8/iso:1


"A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:P49336-2

cyclin-dependent kinase 8 isoform h2 (human)

hCDK8/iso:h2


"A cyclin-dependent kinase 8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49336-2." [PRO:DNx, UniProtKB:P49336]


organism-gene



PR:Q8JH47

cyclin-dependent kinase 8 (zebrafish)

z-CDK8


"A cyclin-dependent kinase 8 that is encoded in the genome of zebrafish." [PRO:DNx]


organism-gene



PR:Q8R3L8

cyclin-dependent kinase 8 (mouse)

mCDK8


"A cyclin-dependent kinase 8 that is encoded in the genome of mouse." [OMA:Q8R3L8, PRO:DNx]


organism-sequence



PR:Q8R3L8-1

cyclin-dependent kinase 8 isoform 1 (mouse)

mCDK8/iso:1


"A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of mouse." [PMID:19468303, PRO:HJD]


Yes
organism-sequence



PR:Q8R3L8-2

cyclin-dependent kinase 8 isoform m2 (mouse)

mCDK8/iso:m2


"A cyclin-dependent kinase 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R3L8-2." [PRO:DNx, UniProtKB:Q8R3L8]


organism-sequence



PR:Q8R3L8-3

cyclin-dependent kinase 8 isoform m3 (mouse)

mCDK8/iso:m3


"A cyclin-dependent kinase 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R3L8-3." [PRO:DNx, UniProtKB:Q8R3L8]


organism-gene



PR:Q95YH0

probable cyclin-dependent kinase 8 (Dictyostelium discoideum)

Dicty-CDK8


"A cyclin-dependent kinase 8 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q95YH0, PRO:DNx]


organism-gene



PR:Q9VT57

cyclin-dependent kinase 8 (fruit fly)

fly-CDK8


"A cyclin-dependent kinase 8 that is encoded in the genome of fruit fly." [OMA:Q9VT57, PRO:DNx]


sequence



PR:000028984

cyclin-dependent kinase 8 isoform 1

CDK8/iso:1


"A cyclin-dependent kinase 8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R3L8-1 or a 1:1 ortholog thereof." [PMID:19468303, PRO:HJD]


organism-sequence



PR:P49336-1

cyclin-dependent kinase 8 isoform 1 (human)

hCDK8/iso:1


"A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of human." [PRO:HJD]


organism-sequence



PR:Q8R3L8-1

cyclin-dependent kinase 8 isoform 1 (mouse)

mCDK8/iso:1


"A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of mouse." [PMID:19468303, PRO:HJD]


Yes
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CDK8 forms found in complexes   

CDK8 Component
Complexes
PR:Q8R3L8ZDASHZ1 mCDK8/iso:1 PR:000028957 mediator complex, CDK8-containing (mouse)