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Protein Ontology report - cell division protein kinase 4
PR:000005257 - http://purl.obolibrary.org/obo/PR_000005257
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000005257   
  PRO namecell division protein kinase 4 
  Synonyms
PRO-Short-label: EXACT:CDK4
Other: EXACT:CRK3 | cyclin-dependent kinase 4 | PSK-J3
  Definition"A CDK2-related kinase that is a translation product of the human CDK4 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000003270 CDK2-related kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1976
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000005257

cell division protein kinase 4

CDK4


"A CDK2-related kinase that is a translation product of the human CDK4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P11802

cyclin-dependent kinase 4 (human)

hCDK4


"A cell division protein kinase 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11802]


organism-sequence



PR:P11802-1

cyclin-dependent kinase 4 isoform 1 (human)

hCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P11802-2

cyclin-dependent kinase 4 isoform h2 (human)

hCDK4/iso:h2


"A cyclin-dependent kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11802-2." [PRO:DNx, UniProtKB:P11802]


organism-modification



PR:000026623

cell division protein kinase 4, initiator methionine removed form (human)

hCDK4/InitMet-


"A cell division protein kinase 4, initiator methionine removed form in human. Example: UniProtKB:P11802-1, 2-303." [PRO:DNx]


Yes
organism-modification



PR:000046675

cell division protein kinase 4, initiator methionine removed phosphorylated 2 (human)

hCDK4/InitMet-/Phos:2


"A cell division protein kinase 4, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Thr-172 of the amino acid sequence represented by UniProtKB:P11802. UniProtKB:P11802, 2-303, Thr-172, MOD:00047." [PRO:DNx, Reactome:R-HSA-113830]


organism-modification



PR:000045672

cyclin-dependent kinase 4 phosphorylated 1 (human)

hCDK4/Phos:1


"A cyclin-dependent kinase 4 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-17 of the amino acid sequence represented by UniProtKB:P11802-1. Example: UniProtKB:P11802-1, Tyr-17, MOD:00048." [iPTMnet:P11802, PMID:18479465]


organism-modification



PR:000067543

cyclin-dependent kinase 4 methylated 1 (human)

hCDK4/Me:1


"A cyclin-dependent kinase 4 (human) that has been methylated on the residue at the position equivalent to Cys-135 of the amino acid sequence represented by UniProtKB:P11802-1. Example: UniProtKB:P11802-1, Cys-135, MOD:00660." [IEDB_epitope:1017336, PRO:DNx]


organism-modification



PR:000073061

cyclin-dependent kinase 4 deaminated 1 (human)

hCDK4/Deam:1


"A cyclin-dependent kinase 4 (human) that has been deaminated on the residue at the position equivalent to Gln-98 of the amino acid sequence represented by UniProtKB:P11802-1. Example: UniProtKB:P11802-1, Gln-98, MOD:00685." [IEDB_epitope:1574114, PRO:DNx]


organism-gene



PR:P30285

cyclin-dependent kinase 4 (mouse)

mCDK4


"A cell division protein kinase 4 that is encoded in the genome of mouse." [OMA:P30285, PRO:DNx]


organism-sequence



PR:P30285-1

cyclin-dependent kinase 4 isoform 1 (mouse)

mCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P35426

cyclin-dependent kinase 4 (rat)

rCDK4


"A cell division protein kinase 4 that is encoded in the genome of rat." [OMA:P35426, PRO:DNx]


organism-sequence



PR:P35426-1

cyclin-dependent kinase 4 isoform 1 (rat)

rCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000038853

cell division protein kinase 4 isoform 1

CDK4/iso:1


"A cell division protein kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11802-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P11802-1

cyclin-dependent kinase 4 isoform 1 (human)

hCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P30285-1

cyclin-dependent kinase 4 isoform 1 (mouse)

mCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P35426-1

cyclin-dependent kinase 4 isoform 1 (rat)

rCDK4/iso:1


"A cell division protein kinase 4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000019288

cell division protein kinase 4, initiator methionine removed form

CDK4/InitMet-


"A cell division protein kinase 4 that has had the initiator methionine removed." [PRO:DNx]


Yes
organism-modification



PR:000026623

cell division protein kinase 4, initiator methionine removed form (human)

hCDK4/InitMet-


"A cell division protein kinase 4, initiator methionine removed form in human. Example: UniProtKB:P11802-1, 2-303." [PRO:DNx]


Yes
organism-modification



PR:000046675

cell division protein kinase 4, initiator methionine removed phosphorylated 2 (human)

hCDK4/InitMet-/Phos:2


"A cell division protein kinase 4, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Thr-172 of the amino acid sequence represented by UniProtKB:P11802. UniProtKB:P11802, 2-303, Thr-172, MOD:00047." [PRO:DNx, Reactome:R-HSA-113830]


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CDK4 forms found in complexes   

CDK4 Component
Complexes
PR:000019288 CDK4/InitMet- PR:000026740 cyclin D1:Cdk4
PR:000027140 cyclin D1:Cdk4 complex phosphorylated 1
PR:000026623 hCDK4/InitMet- PR:000026741 cyclin D1:Cdk4 (human)
PR:000027150 cyclin D1:Cdk4 complex phosphorylated 1 (human)