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Protein Ontology report - cyclin-dependent kinase 2
PR:000005253 - http://purl.obolibrary.org/obo/PR_000005253
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000005253   
  PRO namecyclin-dependent kinase 2 
  Synonyms
PRO-Short-label: EXACT:CDK2
Gene-based: RELATED:CDKN2
Other: EXACT:cell division protein kinase 2
RELATED:p33 protein kinase
  Definition"A CDK2-related kinase that is a translation product of the human CDK2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000003270 CDK2-related kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1973
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000005253
cyclin-dependent kinase 2
CDK2
"A CDK2-related kinase that is a translation product of the human CDK2 gene or a 1:1 ortholog thereof." [PRO:DNx]

Yes
organism-gene


PR:P23573
cyclin-dependent kinase 2 (fruit fly)
fly-CDK2
"A cyclin-dependent kinase 2 that is encoded in the genome of fruit fly." [OMA:P23573, PRO:DNx]

organism-gene


PR:P24941
cyclin-dependent kinase 2 (human)
hCDK2
"A cyclin-dependent kinase 2 that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:P24941-1
cyclin-dependent kinase 2 isoform h1 (human)
hCDK2/iso:h1
"A cyclin-dependent kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24941-1." [PRO:DNx, UniProtKB:P24941]

organism-sequence


PR:P24941-2
cyclin-dependent kinase 2 isoform h2 (human)
hCDK2/iso:h2
"A cyclin-dependent kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24941-2." [PRO:DNx, UniProtKB:P24941]

organism-modification


PR:000028803
cyclin-dependent kinase 2 isoform 1 acetylated 1 (human)
hCDK2/iso:1/Ac:1
"A cyclin-dependent kinase 2 isoform 1 acetylated 1 in human. Acetylation inhibits CDK2 activity. UniProtKB:P24941-1, Lys-33, MOD:00064." [PMID:19773423, PRO:PD]

organism-modification


PR:000043632
cyclin-dependent kinase 2 phosphorylated form (human)
hCDK2/PhosRes+
"A cyclin-dependent kinase 2 phosphorylated form in human. UniProtKB:P24941, MOD:00696." [PRO:DAN]

Yes
organism-modification


PR:000045724
cyclin-dependent kinase 2 phosphorylated 1 (human)
hCDK2/Phos:1
"A cyclin-dependent kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-160 of the amino acid sequence represented by UniProtKB:P24941-1. Example: UniProtKB:P24941-1, Thr-160, MOD:00047." [iPTMnet:P24941, PMID:12359725, PMID:14597612, PMID:17361108, PMID:8443411]

organism-modification


PR:000046674
cyclin-dependent kinase 2 phosphorylated 2 (human)
hCDK2/Phos:2
"A cyclin-dependent kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-15 of the amino acid sequence represented by UniProtKB:P24941. UniProtKB:P24941, Tyr-15, MOD:00048." [PRO:DNx, Reactome:R-HSA-187905]

organism-gene


PR:P97377
cyclin-dependent kinase 2 (mouse)
mCDK2
"A cyclin-dependent kinase 2 that is encoded in the genome of mouse." [OMA:P97377, PRO:DAN]

organism-sequence


PR:P97377-1
cyclin-dependent kinase 2 isoform 1 (mouse)
mCDK2/iso:1
"A cyclin-dependent kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:DAN]

organism-sequence


PR:P97377-2
cyclin-dependent kinase 2 isoform mCDK2-alpha (mouse)
mCDK2/iso:mCDK2-alpha
"A cyclin-dependent kinase 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97377-2." [PRO:DNx, UniProtKB:P97377]

organism-gene


PR:Q63699
cyclin-dependent kinase 2 (rat)
rCDK2
"A cyclin-dependent kinase 2 that is encoded in the genome of rat." [OMA:Q63699, PRO:DAN]

organism-sequence


PR:Q63699-1
cyclin-dependent kinase 2 isoform rCDK2-alpha (rat)
rCDK2/iso:rCDK2-alpha
"A cyclin-dependent kinase 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63699-1." [PRO:DNx, UniProtKB:Q63699]

organism-sequence


PR:Q63699-2
cyclin-dependent kinase 2 isoform rCDK2-beta (rat)
rCDK2/iso:rCDK2-beta
"A cyclin-dependent kinase 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63699-2." [PRO:DNx, UniProtKB:Q63699]

sequence


PR:000028800
cyclin-dependent kinase 2 isoform 1
CDK2/iso:1
"A cyclin-dependent kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97377-1 or a 1:1 ortholog thereof." [PMID:19773423, PRO:PD]

organism-sequence


PR:P97377-1
cyclin-dependent kinase 2 isoform 1 (mouse)
mCDK2/iso:1
"A cyclin-dependent kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:DAN]

modification


PR:000028802
cyclin-dependent kinase 2 isoform 1 acetylated 1
CDK2/iso:1/Ac:1
"A cyclin-dependent kinase 2 isoform 1 that has been acetylated on a Lys residue within the catalytic pocket. Example: UniProtKB:P97377-1, Lys-33, MOD:00064." [PMID:19773423, PRO:PD]

organism-modification


PR:000028803
cyclin-dependent kinase 2 isoform 1 acetylated 1 (human)
hCDK2/iso:1/Ac:1
"A cyclin-dependent kinase 2 isoform 1 acetylated 1 in human. Acetylation inhibits CDK2 activity. UniProtKB:P24941-1, Lys-33, MOD:00064." [PMID:19773423, PRO:PD]

modification


PR:000045380
cyclin-dependent kinase 2 phosphorylated form
CDK2/PhosRes+
"A cyclin-dependent kinase 2 that includes at least one phosphorylated residue." [PRO:DAN]

Yes
organism-modification


PR:000043632
cyclin-dependent kinase 2 phosphorylated form (human)
hCDK2/PhosRes+
"A cyclin-dependent kinase 2 phosphorylated form in human. UniProtKB:P24941, MOD:00696." [PRO:DAN]

Yes
organism-modification


PR:000045724
cyclin-dependent kinase 2 phosphorylated 1 (human)
hCDK2/Phos:1
"A cyclin-dependent kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-160 of the amino acid sequence represented by UniProtKB:P24941-1. Example: UniProtKB:P24941-1, Thr-160, MOD:00047." [iPTMnet:P24941, PMID:12359725, PMID:14597612, PMID:17361108, PMID:8443411]

organism-modification


PR:000046674
cyclin-dependent kinase 2 phosphorylated 2 (human)
hCDK2/Phos:2
"A cyclin-dependent kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-15 of the amino acid sequence represented by UniProtKB:P24941. UniProtKB:P24941, Tyr-15, MOD:00048." [PRO:DNx, Reactome:R-HSA-187905]

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CDK2 forms found in complexes   

CDK2 Component
 Complexes
PR:000005253 CDK2 PR:000026745 cyclin E1:Cdk2 complex
PR:000026746 cyclin E2:Cdk2 complex
PR:000043632 hCDK2/PhosRes+ PR:000027151 cyclin E1:Cdk2 complex phosphorylated form (human)
PR:000027152 cyclin E2:Cdk2 complex phosphorylated form (human)
PR:000045380 CDK2/PhosRes+ PR:000027141 cyclin E1:Cdk2 complex phosphorylated form
PR:000027142 cyclin E2:Cdk2 complex phosphorylated form
PR:P24941 hCDK2 PR:000026768 cyclin E1:Cdk2 complex (human)
PR:000026769 cyclin E2:Cdk2 complex (human)
PR:000028450 CDK2:CABLES1:Wee-1 (human)