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Protein Ontology report - G1/S-specific cyclin-D1
PR:000005121 - http://purl.obolibrary.org/obo/PR_000005121
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005121   
  PRO nameG1/S-specific cyclin-D1 
  Synonyms
PRO-Short-label: EXACT:CCND1
Gene-based: RELATED:BCL1 | Cyl-1 | PRAD1
Other: EXACT:B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | PRAD1 oncogene
  Definition"A cyclin-D that is a translation product of the human CCND1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000050022 cyclin-D
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000005121

G1/S-specific cyclin-D1

CCND1


"A cyclin-D that is a translation product of the human CCND1 gene or a 1:1 ortholog thereof." [PRO:DNx]


Yes
organism-gene



PR:P24385

G1/S-specific cyclin-D1 (human)

hCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P24385-1

G1/S-specific cyclin-D1 isoform 1 (human)

hCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000027132

G1/S-specific cyclin-D1 phosphorylated 1 (human)

hCCND1/Phos:1


"A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]

Yes

Yes
organism-modification



PR:000037511

G1/S-specific cyclin-D1 unphosphorylated 1 (human)

hCCND1/UnPhos:1


"A G1/S-specific cyclin-D1 (human) that lacks phosphorylation at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Thr-286, PR:000026291." [PMID:17407548, PRO:KER]

Yes

organism-modification



PR:000037512

G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)

hCCND1/PhosUbiq:1


"A G1/S-specific cyclin-D1 (human) that has been both phosphorylated at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385 and been multi-ubiquitinated." [PMID:17081987, PMID:17407548, PRO:KER]


organism-modification



PR:000068517

G1/S-specific cyclin-D1 deaminated 1 (human)

hCCND1/Deam:1


"A G1/S-specific cyclin-D1 (human) that has been deaminated on the residue at the position equivalent to Asn-83 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Asn-83, MOD:00684." [IEDB_epitope:1569278, PRO:DNx]


organism-modification



PR:000068576

G1/S-specific cyclin-D1 methylated 1 (human)

hCCND1/Me:1


"A G1/S-specific cyclin-D1 (human) that has been methylated on the residue at the position equivalent to Cys-189 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-189, MOD:00660." [IEDB_epitope:1002026, PRO:DNx]


organism-modification



PR:000070754

G1/S-specific cyclin-D1 deaminated 2 (human)

hCCND1/Deam:2


"A G1/S-specific cyclin-D1 (human) that has been deaminated on the residue at the position equivalent to Asn-216 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Asn-216, MOD:00684." [IEDB_epitope:1582215, PRO:DNx]


organism-modification



PR:000072927

G1/S-specific cyclin-D1 cysteinylated 1 (human)

hCCND1/Cyst:1


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-8 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-8, MOD:00765." [IEDB_epitope:1562781, PRO:DNx]


organism-modification



PR:000075931

G1/S-specific cyclin-D1 cysteinylated 2 (human)

hCCND1/Cyst:2


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-106 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-106, MOD:00765." [IEDB_epitope:1584276, PRO:DNx]


organism-modification



PR:000076531

G1/S-specific cyclin-D1 cysteinylated 3 (human)

hCCND1/Cyst:3


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-247 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-247, MOD:00765." [IEDB_epitope:1562941, PRO:DNx]


organism-modification



PR:000080333

G1/S-specific cyclin-D1 phosphorylated 2 (human)

hCCND1/Phos:2


"A G1/S-specific cyclin-D1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-97 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Ser-97, MOD:00046." [IEDB_epitope:2146501, PRO:DNx]


organism-gene



PR:P25322

G1/S-specific cyclin-D1 (mouse)

mCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of mouse." [OMA:P25322, PRO:DNx]


organism-sequence



PR:P25322-1

G1/S-specific cyclin-D1 isoform 1 (mouse)

mCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000046156

G1/S-specific cyclin-D1 phosphorylated 1 (mouse)

mCCND1/Phos:1


"A G1/S-specific cyclin-D1 (mouse) that has been phosphorylated at Thr-286. UniProtKB:P25322, Thr-286, MOD:00047." [iPTMnet:P25322, PMID:11124803]


organism-gene



PR:P39948

G1/S-specific cyclin-D1 (rat)

rCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of rat." [OMA:P39948, PRO:DNx]


organism-sequence



PR:P39948-1

G1/S-specific cyclin-D1 isoform 1 (rat)

rCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P55169

G1/S-specific cyclin-D1 (chicken)

chick-CCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of chicken." [OMA:P55169, PRO:DNx]


organism-gene



PR:Q90459

G1/S-specific cyclin-D1 (zebrafish)

z-CCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of zebrafish." [OMA:Q90459, PRO:DNx]


sequence



PR:000039111

G1/S-specific cyclin-D1 isoform 1

CCND1/iso:1


"A G1/S-specific cyclin-D1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24385-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P24385-1

G1/S-specific cyclin-D1 isoform 1 (human)

hCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P25322-1

G1/S-specific cyclin-D1 isoform 1 (mouse)

mCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P39948-1

G1/S-specific cyclin-D1 isoform 1 (rat)

rCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000027131

G1/S-specific cyclin-D1 phosphorylated 1

CCND1/Phos:1


"A G1/S-specific cyclin-D1 that includes phosphorylation at a threonine residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. Example: UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]


Yes
organism-modification



PR:000027132

G1/S-specific cyclin-D1 phosphorylated 1 (human)

hCCND1/Phos:1


"A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]

Yes

Yes
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CCND1 forms found in complexes   

CCND1 Component
Complexes
PR:000005121 CCND1 PR:000026740 cyclin D1:Cdk4
PR:000027131 CCND1/Phos:1 PR:000027140 cyclin D1:Cdk4 complex phosphorylated 1
PR:000027132 hCCND1/Phos:1 PR:000027150 cyclin D1:Cdk4 complex phosphorylated 1 (human)
PR:P24385 hCCND1 PR:000026741 cyclin D1:Cdk4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027132 hCCND1/Phos:1
UniProtKB:P24385, Thr-286, MOD:00047
enablesincreased GO:0005515 protein binding with PR:000037513 SCF(FBX4-alphaB crystallin) complex (human) PMID:17407548
PR:000037511 hCCND1/UnPhos:1
UniProtKB:P24385, Thr-286, PR:000026291
associated_with_disease_progressionDO:162 cancer PMID:17407548