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Protein Ontology report - E3 ubiquitin-protein ligase CBL
PR:000005070 - http://purl.obolibrary.org/obo/PR_000005070
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000005070   
  PRO nameE3 ubiquitin-protein ligase CBL 
  Synonyms
PRO-Short-label: EXACT:CBL
Gene-based: RELATED:CBL2 | RNF55
Other: EXACT:casitas B-lineage lymphoma proto-oncogene | proto-oncogene c-Cbl | RING finger protein 55 | RING-type E3 ubiquitin transferase CBL | signal transduction protein CBL
  Definition"A protein that is a translation product of the human CBL gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 29                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000005070
E3 ubiquitin-protein ligase CBL
CBL
"A protein that is a translation product of the human CBL gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P22681
E3 ubiquitin-protein ligase CBL (human)
hCBL
"An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human." [PRO:DNx, UniProtKB:P22681]

organism-sequence


PR:000060726
E3 ubiquitin-protein ligase CBL sequence variant Y371H (human)
hCBL/var:Y371H
"An E3 ubiquitin-protein ligase CBL (human) that has a His residue at the position equivalent to Tyr-371 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-371, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9706680]

organism-sequence


PR:000060850
E3 ubiquitin-protein ligase CBL sequence variant H398Q (human)
hCBL/var:H398Q
"An E3 ubiquitin-protein ligase CBL (human) that has a Gln residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-9706633]

organism-sequence


PR:000060865
E3 ubiquitin-protein ligase CBL sequence variant H398Y (human)
hCBL/var:H398Y
"An E3 ubiquitin-protein ligase CBL (human) that has a Tyr residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-9706639]

organism-sequence


PR:000061246
E3 ubiquitin-protein ligase CBL sequence variant P417A (human)
hCBL/var:P417A
"An E3 ubiquitin-protein ligase CBL (human) that has an Ala residue at the position equivalent to Pro-417 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Pro-417, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9706636]

organism-sequence


PR:000061247
E3 ubiquitin-protein ligase CBL sequence variant K287R (human)
hCBL/var:K287R
"An E3 ubiquitin-protein ligase CBL (human) that has an Arg residue at the position equivalent to Lys-287 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Lys-287, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9706693]

organism-sequence


PR:000061475
E3 ubiquitin-protein ligase CBL sequence variant P417L (human)
hCBL/var:P417L
"An E3 ubiquitin-protein ligase CBL (human) that has a Leu residue at the position equivalent to Pro-417 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Pro-417, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-9706634]

organism-sequence


PR:000061512
E3 ubiquitin-protein ligase CBL sequence variant R420L (human)
hCBL/var:R420L
"An E3 ubiquitin-protein ligase CBL (human) that has a Leu residue at the position equivalent to Arg-420 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-420, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-9706197]

organism-sequence


PR:000061698
E3 ubiquitin-protein ligase CBL sequence variant H398N (human)
hCBL/var:H398N
"An E3 ubiquitin-protein ligase CBL (human) that has an Asn residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9706641]

organism-sequence


PR:000061841
E3 ubiquitin-protein ligase CBL sequence variant S376F (human)
hCBL/var:S376F
"An E3 ubiquitin-protein ligase CBL (human) that has a Phe residue at the position equivalent to Ser-376 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Ser-376, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-9706643]

organism-sequence


PR:000061917
E3 ubiquitin-protein ligase CBL sequence variant P417R (human)
hCBL/var:P417R
"An E3 ubiquitin-protein ligase CBL (human) that has an Arg residue at the position equivalent to Pro-417 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Pro-417, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9706632]

organism-sequence


PR:000061984
E3 ubiquitin-protein ligase CBL sequence variant Y371N (human)
hCBL/var:Y371N
"An E3 ubiquitin-protein ligase CBL (human) that has an Asn residue at the position equivalent to Tyr-371 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-371, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9706679]

organism-sequence


PR:000062033
E3 ubiquitin-protein ligase CBL sequence variant R499Q (human)
hCBL/var:R499Q
"An E3 ubiquitin-protein ligase CBL (human) that has a Gln residue at the position equivalent to Arg-499 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-499, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-9706677]

organism-sequence


PR:000062131
E3 ubiquitin-protein ligase CBL sequence variant Y371C (human)
hCBL/var:Y371C
"An E3 ubiquitin-protein ligase CBL (human) that has a Cys residue at the position equivalent to Tyr-371 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-371, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9706694]

organism-sequence


PR:000062859
E3 ubiquitin-protein ligase CBL sequence variant R420G (human)
hCBL/var:R420G
"An E3 ubiquitin-protein ligase CBL (human) that has a Gly residue at the position equivalent to Arg-420 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-420, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-9706203]

organism-sequence


PR:000062950
E3 ubiquitin-protein ligase CBL sequence variant R420P (human)
hCBL/var:R420P
"An E3 ubiquitin-protein ligase CBL (human) that has a Pro residue at the position equivalent to Arg-420 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-420, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-9706193]

organism-sequence


PR:000063061
E3 ubiquitin-protein ligase CBL sequence variant R420Q (human)
hCBL/var:R420Q
"An E3 ubiquitin-protein ligase CBL (human) that has a Gln residue at the position equivalent to Arg-420 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-420, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-9706186]

organism-sequence


PR:000063137
E3 ubiquitin-protein ligase CBL sequence variant Y371S (human)
hCBL/var:Y371S
"An E3 ubiquitin-protein ligase CBL (human) that has a Ser residue at the position equivalent to Tyr-371 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-371, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9706674]

organism-sequence


PR:000063346
E3 ubiquitin-protein ligase CBL sequence variant G375P (human)
hCBL/var:G375P
"An E3 ubiquitin-protein ligase CBL (human) that has a Pro residue at the position equivalent to Gly-375 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Gly-375, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-9706219]

organism-sequence


PR:000063687
E3 ubiquitin-protein ligase CBL sequence variant G375S (human)
hCBL/var:G375S
"An E3 ubiquitin-protein ligase CBL (human) that has a Ser residue at the position equivalent to Gly-375 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Gly-375, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9706214]

organism-sequence


PR:000063970
E3 ubiquitin-protein ligase CBL sequence variant R499L (human)
hCBL/var:R499L
"An E3 ubiquitin-protein ligase CBL (human) that has a Leu residue at the position equivalent to Arg-499 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Arg-499, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-9706678]

organism-sequence


PR:000064058
E3 ubiquitin-protein ligase CBL sequence variant H398P (human)
hCBL/var:H398P
"An E3 ubiquitin-protein ligase CBL (human) that has a Pro residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-9706637]

organism-sequence


PR:000064132
E3 ubiquitin-protein ligase CBL sequence variant P417S (human)
hCBL/var:P417S
"An E3 ubiquitin-protein ligase CBL (human) that has a Ser residue at the position equivalent to Pro-417 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Pro-417, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-9706642]

organism-sequence


PR:000064133
E3 ubiquitin-protein ligase CBL sequence variant H398D (human)
hCBL/var:H398D
"An E3 ubiquitin-protein ligase CBL (human) that has an Asp residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-9706631]

organism-sequence


PR:000064194
E3 ubiquitin-protein ligase CBL sequence variant H398R (human)
hCBL/var:H398R
"An E3 ubiquitin-protein ligase CBL (human) that has an Arg residue at the position equivalent to His-398 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, His-398, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9706638]

organism-sequence


PR:000064200
E3 ubiquitin-protein ligase CBL sequence variant L380P (human)
hCBL/var:L380P
"An E3 ubiquitin-protein ligase CBL (human) that has a Pro residue at the position equivalent to Leu-380 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Leu-380, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-9706630]

organism-sequence


PR:000064250
E3 ubiquitin-protein ligase CBL sequence variant P417H (human)
hCBL/var:P417H
"An E3 ubiquitin-protein ligase CBL (human) that has a His residue at the position equivalent to Pro-417 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Pro-417, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9706644]

organism-sequence


PR:000064300
E3 ubiquitin-protein ligase CBL sequence variant L380R (human)
hCBL/var:L380R
"An E3 ubiquitin-protein ligase CBL (human) that has an Arg residue at the position equivalent to Leu-380 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Leu-380, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9706635]

organism-sequence


PR:000064402
E3 ubiquitin-protein ligase CBL sequence variant Y371D (human)
hCBL/var:Y371D
"An E3 ubiquitin-protein ligase CBL (human) that has an Asp residue at the position equivalent to Tyr-371 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-371, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-9706687]

organism-sequence


PR:P22681-1
E3 ubiquitin-protein ligase CBL isoform 1 (human)
hCBL/iso:1
"An E3 ubiquitin-protein ligase CBL isoform 1 that is encoded in the genome of human." [PRO:CNx]

organism-modification


PR:000026223
E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 (human)
hCBL/iso:1/Phos:1
"An E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 in human. UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx]

organism-modification


PR:000045714
E3 ubiquitin-protein ligase CBL phosphorylated 1 (human)
hCBL/Phos:1
"An E3 ubiquitin-protein ligase CBL (human) that has been phosphorylated at Tyr-731. UniProtKB:P22681, Tyr-731, MOD:00048." [iPTMnet:P22681, PMID:14739300]

organism-modification


PR:000046577
E3 ubiquitin-protein ligase CBL phosphorylated 2 (human)
hCBL/Phos:2
"An E3 ubiquitin-protein ligase CBL (human) that has been post-translationally modified to include phosphotyrosine at positions 700, 731 and 774 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-700/Tyr-731/Tyr-774, MOD:00048." [PRO:DNx, Reactome:R-HSA-912656]

organism-modification


PR:000063002
E3 ubiquitin-protein ligase CBL phosphotyrosine form (human)
hCBL/PhosTyr+
"An E3 ubiquitin-protein ligase CBL (human) that includes at least one phosphorylated tyrosine. UniProtKB:P22681, MOD:00048." [PRO:DNx, Reactome:R-HSA-8875457]

organism-modification


PR:000064823
E3 ubiquitin-protein ligase CBL phosphorylated and ubiquitinated 1 (human)
hCBL/PhosUbiq:1
"An E3 ubiquitin-protein ligase CBL (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-700, Tyr-731, and Tyr-774 of the amino acid sequence represented by UniProtKB:P22681 and that includes at least one ubiquitinated lysine. UniProtKB:P22681, Tyr-700/Tyr-731/Tyr-774, MOD:00048|MOD:01148." [PRO:DNx, Reactome:R-HSA-8848826]

organism-modification


PR:000064834
E3 ubiquitin-protein ligase CBL phosphotyrosine and ubiquitinated form (human)
hCBL/pTyrUbiq+
"An E3 ubiquitin-protein ligase CBL (human) that includes at least one phosphorylated tyrosine and at least one ubiquitinated lysine. UniProtKB:P22681, MOD:00048|MOD:01148." [PRO:DNx, Reactome:R-HSA-9763893]

organism-modification


PR:000065420
E3 ubiquitin-protein ligase CBL phosphorylated 3 (human)
hCBL/Phos:3
"An E3 ubiquitin-protein ligase CBL (human) that has been phosphorylated on the residue at the position equivalent to Thr-317 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Thr-317, MOD:00047." [IEDB_epitope:2149366, PRO:DNx]

organism-modification


PR:000071277
E3 ubiquitin-protein ligase CBL methylated 1 (human)
hCBL/Me:1
"An E3 ubiquitin-protein ligase CBL (human) that has been methylated on the residue at the position equivalent to Cys-372 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Cys-372, MOD:00660." [IEDB_epitope:1032570, PRO:DNx]

organism-modification


PR:000076742
E3 ubiquitin-protein ligase CBL phosphorylated 4 (human)
hCBL/Phos:4
"An E3 ubiquitin-protein ligase CBL (human) that has been phosphorylated on the residue at the position equivalent to Thr-91 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Thr-91, MOD:00047." [IEDB_epitope:1328080, PRO:DNx]

organism-modification


PR:000083679
E3 ubiquitin-protein ligase CBL methylated 2 (human)
hCBL/Me:2
"An E3 ubiquitin-protein ligase CBL (human) that has been methylated on the residue at the position equivalent to Cys-59 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Cys-59, MOD:00660." [IEDB_epitope:1025573, PRO:DNx]

organism-gene


PR:P22682
E3 ubiquitin-protein ligase CBL (mouse)
mCBL
"An E3 ubiquitin-protein ligase CBL that is encoded in the genome of mouse." [OMA:P22682, PRO:DNx]

organism-modification


PR:000073341
E3 ubiquitin-protein ligase CBL phosphorylated 1 (mouse)
mCBL/Phos:1
"An E3 ubiquitin-protein ligase CBL (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-767 of the amino acid sequence represented by UniProtKB:P22682. UniProtKB:P22682, Ser-767, MOD:00046." [IEDB_epitope:239011, PRO:DNx]

sequence


PR:000026186
E3 ubiquitin-protein ligase CBL isoform 1
CBL/iso:1
"An E3 ubiquitin-protein ligase CBL that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22681-1 or a 1:1 ortholog thereof." [PRO:CNx]

organism-sequence


PR:P22681-1
E3 ubiquitin-protein ligase CBL isoform 1 (human)
hCBL/iso:1
"An E3 ubiquitin-protein ligase CBL isoform 1 that is encoded in the genome of human." [PRO:CNx]

organism-modification


PR:000026223
E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 (human)
hCBL/iso:1/Phos:1
"An E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 in human. UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx]

modification


PR:000026188
E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1
CBL/iso:1/Phos:1
"An E3 ubiquitin-protein ligase CBL isoform 1 that has been phosphorylated by tyrosine kinase receptors, such as EGFR or INSR. This tyrosine phosphorylation is necessary for activation of the ubiquitin ligase activity. Example: UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx, Reactome:R-HSA-182923, Reactome:R-HSA-182940]

organism-modification


PR:000026223
E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 (human)
hCBL/iso:1/Phos:1
"An E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 in human. UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx]