back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - outer kinetochore KNL1 complex subunit KNL1
PR:000005050 - http://purl.obolibrary.org/obo/PR_000005050
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000005050   
  PRO nameouter kinetochore KNL1 complex subunit KNL1 
  Synonyms
PRO-Short-label: EXACT:KNL1
Gene-based: RELATED:CASC5 | KIAA1570
Other: EXACT:AF15q14 | ALL1-fused gene from chromosome 15q14 | blinkin | Bub-linking kinetochore protein | cancer susceptibility candidate gene 5 protein | cancer/testis antigen 29 | CT29 | kinetochore scaffold 1 | kinetochore-null protein 1 | protein CASC5 | protein D40/AF15q14
  Definition"A protein that is a translation product of the human KNL1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000005050
outer kinetochore KNL1 complex subunit KNL1
KNL1
"A protein that is a translation product of the human KNL1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:D3Z896
protein LOC100911204 (rat)
rKNL1
"An outer kinetochore KNL1 complex subunit KNL1 that is encoded in the genome of rat." [PRO:DNx]

organism-gene


PR:Q66JQ7
outer kinetochore KNL1 complex subunit KNL1 (mouse)
mKNL1
"An outer kinetochore KNL1 complex subunit KNL1 that is encoded in the genome of mouse." [OMA:Q66JQ7, PRO:DNx]

organism-sequence


PR:Q66JQ7-1
outer kinetochore KNL1 complex subunit KNL1 isoform m1 (mouse)
mKNL1/iso:m1
"An outer kinetochore KNL1 complex subunit KNL1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q66JQ7-1." [PRO:DNx, UniProtKB:Q66JQ7]

organism-sequence


PR:Q66JQ7-2
outer kinetochore KNL1 complex subunit KNL1 isoform m2 (mouse)
mKNL1/iso:m2
"An outer kinetochore KNL1 complex subunit KNL1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q66JQ7-2." [PRO:DNx, UniProtKB:Q66JQ7]

organism-gene


PR:Q8NG31
outer kinetochore KNL1 complex subunit KNL1 (human)
hKNL1
"An outer kinetochore KNL1 complex subunit KNL1 that is encoded in the genome of human." [PMID:20624902, PRO:KER]
Yes
organism-sequence


PR:Q8NG31-1
outer kinetochore KNL1 complex subunit KNL1 isoform 1 (human)
hKNL1/iso:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:Q8NG31-2
outer kinetochore KNL1 complex subunit KNL1 isoform 2 (human)
hKNL1/iso:2
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000035558
outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 (human)
hKNL1/iso:2/Phos:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 in human. UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047|Ser-1022/Ser-1037, MOD:00046." [PMID:22660415, PRO:KER]
Yes
organism-modification


PR:000035560
outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form (human)
hKNL1/iso:2/PhosRes-
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form in human." [PRO:KER]

organism-sequence


PR:Q8NG31-3
outer kinetochore KNL1 complex subunit KNL1 isoform h3 (human)
hKNL1/iso:h3
"An outer kinetochore KNL1 complex subunit KNL1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NG31-3." [PRO:DNx, UniProtKB:Q8NG31]

organism-sequence


PR:Q8NG31-4
outer kinetochore KNL1 complex subunit KNL1 isoform h4 (human)
hKNL1/iso:h4
"An outer kinetochore KNL1 complex subunit KNL1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NG31-4." [PRO:DNx, UniProtKB:Q8NG31]

organism-modification


PR:000071007
outer kinetochore KNL1 complex subunit KNL1 methylated 1 (human)
hKNL1/Me:1
"An outer kinetochore KNL1 complex subunit KNL1 (human) that has been methylated on the residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:Q8NG31-1. Example: UniProtKB:Q8NG31-1, Cys-130, MOD:00660." [IEDB_epitope:1036496, PRO:DNx]

organism-modification


PR:000071490
outer kinetochore KNL1 complex subunit KNL1 cysteinylated 1 (human)
hKNL1/Cyst:1
"An outer kinetochore KNL1 complex subunit KNL1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-2338 of the amino acid sequence represented by UniProtKB:Q8NG31-1. Example: UniProtKB:Q8NG31-1, Cys-2338, MOD:00765." [IEDB_epitope:1564396, PRO:DNx]

organism-modification


PR:000077771
outer kinetochore KNL1 complex subunit KNL1 phosphorylated 1 (human)
hKNL1/Phos:1
"An outer kinetochore KNL1 complex subunit KNL1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1773 of the amino acid sequence represented by UniProtKB:Q8NG31-1. Example: UniProtKB:Q8NG31-1, Ser-1773, MOD:00046." [IEDB_epitope:609244, PRO:DNx]

organism-modification


PR:000083702
outer kinetochore KNL1 complex subunit KNL1 deaminated 1 (human)
hKNL1/Deam:1
"An outer kinetochore KNL1 complex subunit KNL1 (human) that has been deaminated on the residue at the position equivalent to Asn-1514 of the amino acid sequence represented by UniProtKB:Q8NG31-1. Example: UniProtKB:Q8NG31-1, Asn-1514, MOD:00684." [IEDB_epitope:1365942, PRO:DNx]

sequence


PR:000035553
outer kinetochore KNL1 complex subunit KNL1 isoform 1
KNL1/iso:1
"An outer kinetochore KNL1 complex subunit KNL1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NG31-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q8NG31-1
outer kinetochore KNL1 complex subunit KNL1 isoform 1 (human)
hKNL1/iso:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

sequence


PR:000035555
outer kinetochore KNL1 complex subunit KNL1 isoform 2
KNL1/iso:2
"An outer kinetochore KNL1 complex subunit KNL1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NG31-2 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q8NG31-2
outer kinetochore KNL1 complex subunit KNL1 isoform 2 (human)
hKNL1/iso:2
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000035558
outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 (human)
hKNL1/iso:2/Phos:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 in human. UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047|Ser-1022/Ser-1037, MOD:00046." [PMID:22660415, PRO:KER]
Yes
organism-modification


PR:000035560
outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form (human)
hKNL1/iso:2/PhosRes-
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form in human." [PRO:KER]

modification


PR:000035557
outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1
KNL1/iso:2/Phos:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 that has been phosphorylated on Ser or Thr residues within the MELT repeats (M[ED][LI][TS]) and three related sequences ([ED]x[T/S]) in the middle region. Example: UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047|Ser-1022/Ser-1037, MOD:00046." [PMID:22660415, PRO:KER]

organism-modification


PR:000035558
outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 (human)
hKNL1/iso:2/Phos:1
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 phosphorylated 1 in human. UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047|Ser-1022/Ser-1037, MOD:00046." [PMID:22660415, PRO:KER]
Yes
modification


PR:000035559
outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form
KNL1/iso:2/PhosRes-
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 that lacks phosphorylated residues." [PRO:KER]

organism-modification


PR:000035560
outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form (human)
hKNL1/iso:2/PhosRes-
"An outer kinetochore KNL1 complex subunit KNL1 isoform 2 unphosphorylated form in human." [PRO:KER]

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035558 hKNL1/iso:2/Phos:1
UniProtKB:Q8NG31-2, Thr-875/Thr-1075/Thr-1089/Thr-1129/Thr-1154/Thr-1167, MOD:00047|Ser-1022/Ser-1037, MOD:00046		 acts_upstream_of_or_withinincreased GO:0034501 protein localization to kinetochore relative to PR:000035560 hKNL1/iso:2/PhosRes- PMID:22660415
PR:Q8NG31 hKNL1 enablesGO:0005515 protein binding with PR:O14777 HEC BioGRID:BG-697221
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-697221
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-697221
located_inGO:0000776 kinetochore PMID:20624902