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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000004855 - http://purl.obolibrary.org/obo/PR_000004855
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004855   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta 
  Synonyms
PRO-Short-label: EXACT:BUB1B
Gene-based: RELATED:BUBR1 | MAD3L | SSK1
Other: EXACT:BubR1 | MAD3/BUB1-related protein kinase | mitotic checkpoint kinase MAD3L | protein SSK1
  Definition"A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000035665 BUB1/BUB1B protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification6                                                  Organism-Modification 20                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1950
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000004855

mitotic checkpoint serine/threonine-protein kinase BUB1 beta

BUB1B


"A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]


organism-gene



PR:O60566

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)

hBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566]

Yes

Yes
organism-sequence



PR:O60566-1

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human)

hBUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


organism-sequence



PR:O60566-2

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human)

hBUB1B/iso:h2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-2." [PRO:DNx, UniProtKB:O60566]


organism-sequence



PR:O60566-3

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human)

hBUB1B/iso:h3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-3." [PRO:DNx, UniProtKB:O60566]


organism-modification



PR:000035362

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)

hBUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]

Yes

organism-modification



PR:000035373

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)

hBUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA]

Yes

Yes
organism-modification



PR:000035428

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)

hBUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]

Yes

Yes
organism-modification



PR:000035432

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

hBUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

Yes

organism-modification



PR:000035435

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)

hBUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]

Yes

organism-modification



PR:000065892

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 1 (human)

hBUB1B/Me:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-356 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-356, MOD:00660." [IEDB_epitope:1044994, PRO:DNx]


organism-modification



PR:000066223

mitotic checkpoint serine/threonine-protein kinase BUB1 beta cysteinylated 1 (human)

hBUB1B/Cyst:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been cysteinylated on the residue at the position equivalent to Cys-775 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-775, MOD:00765." [IEDB_epitope:1338170, PRO:DNx]


organism-modification



PR:000070779

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 1 (human)

hBUB1B/Deam:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-652 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-652, MOD:00685." [IEDB_epitope:889434, PRO:DNx]


organism-modification



PR:000074218

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 2 (human)

hBUB1B/Deam:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-56 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-56, MOD:00685." [IEDB_epitope:1584837, PRO:DNx]


organism-modification



PR:000074309

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 2 (human)

hBUB1B/Me:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-775 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-775, MOD:00660." [IEDB_epitope:1061689, PRO:DNx]


organism-modification



PR:000076756

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 3 (human)

hBUB1B/Me:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-51 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-51, MOD:00660." [IEDB_epitope:1001673, PRO:DNx]


organism-modification



PR:000077474

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 4 (human)

hBUB1B/Me:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-841 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-841, MOD:00660." [IEDB_epitope:1019154, PRO:DNx]


organism-modification



PR:000077494

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 3 (human)

hBUB1B/Deam:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-57 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-57, MOD:00685." [IEDB_epitope:1584838, PRO:DNx]


organism-modification



PR:000078944

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 5 (human)

hBUB1B/Me:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-832 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-832, MOD:00660." [IEDB_epitope:1062323, PRO:DNx]


organism-modification



PR:000080893

mitotic checkpoint serine/threonine-protein kinase BUB1 beta citrullinated 1 (human)

hBUB1B/Cit:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been citrullinated on the residue at the position equivalent to Arg-786 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Arg-786, MOD:00219." [IEDB_epitope:911971, PRO:DNx]


organism-gene



PR:P41695

spindle assembly checkpoint serine/threonine-protein kinase BUB1 (yeast)

yBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of yeast." [OMA:P41695, PRO:CNA, PRO:DAN]

Yes

Yes
organism-gene



PR:Q800D4

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (chicken)

chick-BUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of chicken." [PMID:17276342, PRO:KER]

Yes

organism-gene



PR:Q8JGT8

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (frog)

frog-BUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of frog." [PMID:12163471, PMID:15241477, PMID:16950116, PRO:KER]

Yes

Yes
organism-modification



PR:000035425

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog)

frog-BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035426

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog)

frog-BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER]

Yes

organism-modification



PR:000035430

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)

frog-BUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER]

Yes

organism-modification



PR:000035433

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog)

frog-BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in frog. UniProtKB:Q8JGT8, Thr-593, MOD:00047." [PMID:22801780, PRO:KER]


organism-gene



PR:Q9Z1S0

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (mouse)

mBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of mouse." [OMA:Q9Z1S0, PRO:DNx]


sequence



PR:000028795

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1

BUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-1 or a 1:1 ortholog thereof." [PMID:19407811, PRO:PD]


organism-sequence



PR:O60566-1

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human)

hBUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


modification



PR:000028797

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1

BUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that has been acetylated on the Lys residue within the conserved sequence RVGGALKA. Example: UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


modification



PR:000035361

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1

BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-620 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]


organism-modification



PR:000035362

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)

hBUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]

Yes

organism-modification



PR:000035426

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog)

frog-BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER]

Yes

modification



PR:000035372

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form

BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000035373

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)

hBUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA]

Yes

Yes
organism-modification



PR:000035425

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog)

frog-BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in frog." [PRO:CNA]


modification



PR:000035427

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form

BUB1B/Phos:CDK1+PLK1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated at one or more CDK1 and PLK1 consensus sites. The phosphorylation at CDK1 site(s) is necessary for the phosphorylation at the PLK1 site(s) to occur. Example: UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PRO:KER]


organism-modification



PR:000035428

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)

hBUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]

Yes

Yes
organism-modification



PR:000035430

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)

frog-BUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER]

Yes

modification



PR:000035431

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3

BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-608 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]


organism-modification



PR:000035432

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

hBUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

Yes

organism-modification



PR:000035433

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog)

frog-BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in frog. UniProtKB:Q8JGT8, Thr-593, MOD:00047." [PMID:22801780, PRO:KER]


modification



PR:000035434

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4

BUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on residues at positions equivalent to Ser-543, Ser-670, and Ser-1043 of the amino acid sequence represented by UniProtKB:O60566-1. Additional Ser residues could be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]


organism-modification



PR:000035435

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)

hBUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]

Yes

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BUB1B forms found in complexes   

BUB1B Component
Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035563 BUB1B:BUB3 complex (human)
PR:000035575 BUB1B:CDC20 complex (human)
PR:P41695 yBUB1B PR:000035565 BUB1:BUB3 complex (yeast)
PR:Q8JGT8 frog-BUB1B PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035362 hBUB1B/Phos:1
Example: UniProtKB:O60566-1, Thr-620, MOD:00047
enablesincreased GO:0005515 protein binding with PR:P53350 hPLK1 PMID:17785528
PR:000035373 hBUB1B/PhosRes- acts_upstream_of_or_withinGO:0001933 negative regulation of protein phosphorylation PMID:22801780
GO:0010826 negative regulation of centrosome duplication PMID:19503101
GO:0033673 negative regulation of kinase activity PMID:19503101
enablesGO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_inGO:0000776 kinetochore PMID:22801780
GO:0005813 centrosome PMID:19503101
PR:000035426 frog-BUB1B/Phos:1
UniProtKB:Q8JGT8, Thr-605, MOD:00047
acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
enablesincreased GO:0005515 protein binding with PR:P70032 frog-plk1 PMID:17998400
PR:000035428 hBUB1B/Phos:2
Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)
acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597
located_inGO:0000776 kinetochore PMID:17785528
PR:000035430 frog-BUB1B/Phos:2
UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17998400
PR:000035432 hBUB1B/Phos:3
Example: UniProtKB:O60566-1, Thr-608, MOD:00047
acts_upstream_of_or_withindecreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_inGO:0000776 kinetochore PMID:22801780
PR:000035435 hBUB1B/Phos:4
Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046
acts_upstream_of_or_withinincreased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317; PMID:20016069
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
located_inGO:0000776 kinetochore PMID:19015317
PR:O60566 hBUB1B acts_upstream_of_or_withinGO:0006469 negative regulation of protein kinase activity PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:11030144
GO:0031647 regulation of protein stability PMID:17671183
NOT GO:0034501 protein localization to kinetochore PMID:16760428
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
enablesGO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 BioGRID:BG-682429
GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- BioGRID:BG-682429
GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-682429
GO:0005515 protein binding with PR:O15379 HD3 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-682429
GO:0005515 protein binding with PR:O76070 BCSG1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O95997 EAP1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P04049 cRaf (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P04637-1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-682429
GO:0005515 protein binding with PR:P51587 BRCA2 BioGRID:BG-682429
GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q02224 CENP-E (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13042 ANAPC6 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13547 HD1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92769 HD2 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96GD4 AIK2 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96IF1 AJUBA BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H4B4 CNK BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX3 ANAPC7 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX5 ANAPC4 BioGRID:BG-682429
GO:0016301 kinase activity PMID:11030144
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470; PMID:16760428
GO:0000922 spindle pole PMID:15190214
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804
GO:0005737 cytoplasm PMID:10749118
PR:P41695 yBUB1B acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
enablesGO:0005515 protein binding with PR:000035536 UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047 PMID:7969164
GO:0005515 protein binding with PR:P26449 BUB3 PMID:7969164
located_inGO:0000776 kinetochore PMID:22521787
PR:Q800D4 chick-BUB1B located_inGO:0000776 kinetochore PMID:17276342
PR:Q8JGT8 frog-BUB1B acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0051310 metaphase chromosome alignment PMID:17709426
enablesGO:0004672 protein kinase activity PMID:12163471
GO:0005515 protein binding with PR:P70039 apc PMID:12163471
GO:0005515 protein binding with PR:P79935 frog-MAD2L1 PMID:12163471
GO:0005515 protein binding with PR:Q6DFD4 fizzy PMID:12163471
GO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:12163471
GO:0005515 protein binding PMID:12163471
located_inGO:0000776 kinetochore PMID:12163471; PMID:17709426
GO:0005694 chromosome PMID:15241477; PMID:16950116