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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1
PR:000004854 - http://purl.obolibrary.org/obo/PR_000004854
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004854   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 
  Synonyms
PRO-Short-label: EXACT:BUB1
Gene-based: RELATED:BUB1L
Other: EXACT:BUB1A
  Definition"A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000035665 BUB1/BUB1B protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification9                                                  Organism-Modification 29                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1949
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000004854

mitotic checkpoint serine/threonine-protein kinase BUB1

BUB1


"A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]


organism-gene



PR:O08901

mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse)

mBUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of mouse." [OMA:O08901, PMID:19965387, PMID:20057499, PRO:KER]

Yes

organism-modification



PR:000035408

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse)

mBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in mouse." [PMID:11792804, PRO:KER]


organism-modification



PR:000035416

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse)

mBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in mouse." [PRO:CNA]


organism-gene



PR:O22806

mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana)

At-BUBR1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]


organism-sequence



PR:O22806-1

mitotic spindle checkpoint protein BUBR1 isoform 1 (Arabidopsis thaliana)

At-BUBR1/iso:1


"A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-1." [PRO:DNx, UniProtKB:O22806]


organism-sequence



PR:O22806-2

mitotic spindle checkpoint protein BUBR1 isoform 2 (Arabidopsis thaliana)

At-BUBR1/iso:2


"A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-2." [PRO:DNx, UniProtKB:O22806]


organism-gene



PR:O43683

mitotic checkpoint serine/threonine-protein kinase BUB1 (human)

hBUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]

Yes

Yes
organism-sequence



PR:O43683-1

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human)

hBUB1/iso:h1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-1." [PRO:DNx, UniProtKB:O43683]


organism-sequence



PR:O43683-2

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human)

hBUB1/iso:h2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-2." [PRO:DNx, UniProtKB:O43683]


organism-sequence



PR:O43683-3

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human)

hBUB1/iso:h3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-3." [PRO:DNx, UniProtKB:O43683]


organism-modification



PR:000035399

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)

hBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]


organism-modification



PR:000035405

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)

hBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]

Yes

organism-modification



PR:000035407

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)

hBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035412

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)

hBUB1/Phos:7


"A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]

Yes

Yes
organism-modification



PR:000035418

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)

hBUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]


organism-modification



PR:000035421

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)

hBUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]

Yes

organism-modification



PR:000065566

mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 1 (human)

hBUB1/Cyst:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-911 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-911, MOD:00765." [IEDB_epitope:933065, PRO:DNx]


organism-modification



PR:000066031

mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 2 (human)

hBUB1/Cyst:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-339 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-339, MOD:00765." [IEDB_epitope:1568023, PRO:DNx]


organism-modification



PR:000071538

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 1 (human)

hBUB1/Me:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-407 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-407, MOD:00660." [IEDB_epitope:1004377, PRO:DNx]


organism-modification



PR:000072604

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 1 (human)

hBUB1/Deam:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Gln-680 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Gln-680, MOD:00685." [IEDB_epitope:1995227, PRO:DNx]


organism-modification



PR:000073548

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (human)

hBUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-661 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Ser-661, MOD:00046." [IEDB_epitope:610301, PRO:DNx]


organism-modification



PR:000073549

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 2 (human)

hBUB1/Deam:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-879 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-879, MOD:00684." [IEDB_epitope:1590063, PRO:DNx]


organism-modification



PR:000076189

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 3 (human)

hBUB1/Deam:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-91 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-91, MOD:00684." [IEDB_epitope:1340837, PRO:DNx]


organism-modification



PR:000076708

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 4 (human)

hBUB1/Deam:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-860 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-860, MOD:00684." [IEDB_epitope:1573110, PRO:DNx]


organism-modification



PR:000076926

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 5 (human)

hBUB1/Deam:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Gln-123 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Gln-123, MOD:00685." [IEDB_epitope:1350453, PRO:DNx]


organism-modification



PR:000078756

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 2 (human)

hBUB1/Me:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-997 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-997, MOD:00660." [IEDB_epitope:1056400, PRO:DNx]


organism-modification



PR:000079803

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 3 (human)

hBUB1/Me:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-339 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-339, MOD:00660." [IEDB_epitope:1008541, IEDB_epitope:1031438, PRO:DNx]


organism-gene



PR:Q21776

mitotic checkpoint serine/threonine-protein kinase bub-1 (worm)

BUB1 (worm)


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of worm." [PANTHER:PTHR14030:SF0, PRO:DNx]


organism-gene



PR:Q54CV5

probable inactive serine/threonine-protein kinase bub1 (Dictyostelium discoideum)

Dicty-BUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Dictyostelium discoideum." [PANTHER:PTHR14030:SF0, PRO:DNx]


organism-gene



PR:Q6GPC9

mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)

frog-bub1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of frog." [PRO:DNx, UniProtKB:Q6GPC9]


organism-sequence



PR:Q98UH3

mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog)

frog-BUB1/var:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q98UH3." [PMID:11231148, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000029911

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)

frog-BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]

Yes

organism-modification



PR:000029913

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)

frog-BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]


organism-modification



PR:000029917

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)

frog-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035404

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)

frog-BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]

Yes

modification



PR:000029910

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1

BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated as a result of activation of the MAPK pathway." [PMID:11231148, PRO:KER]


organism-modification



PR:000029911

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)

frog-BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]

Yes

modification



PR:000029912

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2

BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated by autocatalysis." [PMID:11231148, PRO:KER]


organism-modification



PR:000029913

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)

frog-BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]


organism-modification



PR:000035399

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)

hBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]


organism-modification



PR:000035401

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (yeast)

yBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in yeast." [PMID:7969164, PRO:KER]


modification



PR:000029916

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000029917

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)

frog-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035405

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)

hBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]

Yes

organism-modification



PR:000035414

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in Schizosaccharomyces pombe 972h-." [PRO:CNA]


organism-modification



PR:000035415

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (yeast)

yBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in yeast." [PRO:CNA]


organism-modification



PR:000035416

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse)

mBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in mouse." [PRO:CNA]


modification



PR:000035403

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3

BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been hyperphosphorylated within the amino-terminal noncatalytic region and induced by a lack of microtubule occupancy at kinetochores. Example: UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]


organism-modification



PR:000035404

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)

frog-BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]

Yes

modification



PR:000035406

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4

BUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to spindle damage (including treatment with taxol)." [PMID:11792804, PMID:15525512, PRO:KER]


organism-modification



PR:000035407

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)

hBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035408

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse)

mBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in mouse." [PMID:11792804, PRO:KER]


modification



PR:000035413

BUB1 CDK-consensus sites phosphorylated form

BUB1/PhosRes+


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is phosphorylated on CDK consensus sites (S/T-P-X-K/R) located in the middle region of BUB1." [PMID:12606573, PMID:16760428, PRO:KER]


organism-modification



PR:000035411

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/Phos:6


"A BUB1 CDK-consensus sites phosphorylated form in Schizosaccharomyces pombe 972h-. The exact combination of phosphorylated sites is not known but may involve Thr-340, Thr-423, Thr-455, and/or Ser-466 of the amino acid sequence represented by UniProtKB:O94751. UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)." [PMID:12606573, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000035412

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)

hBUB1/Phos:7


"A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]

Yes

Yes
organism-modification



PR:000035419

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast)

yBUB1/Phos:CDK-1


"A BUB1 CDK-consensus sites phosphorylated form in yeast that has phosphorylation at Thr-566. This phosphorylation is essential for deactivating the spindle checkpoint in anaphase and adaptation to prolonged mitotic arrest. UniProtKB:P41695, Thr-566, MOD:00047." [PMID:21298086, PRO:KER]

Yes

modification



PR:000035417

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8

BUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated on the residue at the position equivalent to Thr-609 (by CDK1) and that has been phosphorylated on at least one residue by PLK1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:DAN, PRO:KER]


organism-modification



PR:000035418

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)

hBUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]


modification



PR:000035420

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10

BUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to DNA damage, mitosis or spindle depolymerization. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]


organism-modification



PR:000035421

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)

hBUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]

Yes

modification



PR:000035691

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5

BUB1/Phos:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that represents the basal phosphorylated state observed during interphase and mitosis." [PRO:CNA, PRO:DAN]


organism-modification



PR:000035410

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/Phos:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 in Schizosaccharomyces pombe 972h-. This form represents the basal phosphorylated state observed during interphase and mitosis." [PMID:12606573, PRO:KER]

Yes

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BUB1 forms found in complexes   

BUB1 Component
Complexes
PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)
PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human)
PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:000035576 BUB1:BUB3:APC complex (human)
PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:000035579 BUB1:unphosphoBUB1B complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029911 frog-BUB1/Phos:1
Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)
enablesincreased GO:0016301 kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:11231148
PR:000035404 frog-BUB1/Phos:3
UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046
acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
enablesincreased GO:0004672 protein kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:15241477
PR:000035405 hBUB1/PhosRes- enablesNOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_inGO:0000776 kinetochore PMID:16760428
PR:000035407 hBUB1/Phos:4 enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
PR:000035410 Spom972h-BUB1/Phos:5
This form represents the basal phosphorylated state observed during interphase and mitosis
acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
PR:000035411 Spom972h-BUB1/Phos:6
UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)
acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
located_inGO:0000776 kinetochore PMID:12606573
PR:000035412 hBUB1/Phos:7
Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047
acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:16760428
enablesincreased GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428
PR:000035419 yBUB1/Phos:CDK-1
UniProtKB:P41695, Thr-566, MOD:00047
acts_upstream_of_or_withinNOT GO:0031577 spindle checkpoint signaling PMID:21298086
PR:000035421 hBUB1/Phos:10
Example: UniProtKB:O43683-1, Ser-314, MOD:00046
acts_upstream_of_or_withinGO:0006281 DNA repair PMID:22071147
GO:0031577 spindle checkpoint signaling PMID:22099307
enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_inGO:0035861 site of double-strand break PMID:22071147
PR:O08901 mBUB1 acts_upstream_of_or_withinGO:0043069 negative regulation of programmed cell death PMID:20057499
located_inGO:0000775 chromosome, centromeric region PMID:19965387
PR:O43683 hBUB1 acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:16580887
GO:0007062 sister chromatid cohesion PMID:16580887
GO:0031577 spindle checkpoint signaling PMID:15525512
GO:0043066 negative regulation of apoptotic process PMID:19252416
GO:0043069 negative regulation of programmed cell death PMID:20057499
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
enablesGO:0004672 protein kinase activity PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P04637-1 PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:P53350 hPLK1 PMID:10198256
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
GO:0005515 protein binding PMID:10198256
located_inGO:0000776 kinetochore PMID:20624902
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804; PMID:16760428
PR:Q98UH3 frog-BUB1/var:1 acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:12163471
enablesGO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:11231148
located_inGO:0000776 kinetochore PMID:11231148; PMID:12163471
GO:0005694 chromosome PMID:15241477; PMID:16950116