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Protein Ontology report - serine-protein kinase ATM
PR:000004427 - http://purl.obolibrary.org/obo/PR_000004427
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004427   
  PRO nameserine-protein kinase ATM 
  Synonyms
PRO-Short-label: EXACT:ATM
Other: EXACT:A-T mutated | A-T mutated homolog | ataxia telangiectasia mutated | ataxia telangiectasia mutated homolog
  Definition"A protein that is a translation product of the human ATM gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification3                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1934
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000004427

serine-protein kinase ATM

ATM


"A protein that is a translation product of the human ATM gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O74630

serine/threonine-protein kinase tel1 (Schizosaccharomyces pombe 972h-)

Spom972h-ATM


"A serine-protein kinase ATM that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]


organism-gene



PR:Q13315

serine-protein kinase ATM (human)

hATM


"A serine-protein kinase ATM that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q13315-1

serine-protein kinase ATM isoform 1 (human)

hATM/iso:1


"A serine-protein kinase ATM isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026217

serine-protein kinase ATM isoform 1 phosphorylated 1 (human)

hATM/iso:1/Phos:1


"A serine-protein kinase ATM isoform 1 phosphorylated 1 in human. UniProtKB:Q13315-1, Ser-1981, MOD:00046." [PRO:CNx]


organism-modification



PR:000035423

serine-protein kinase ATM phosphorylated 2 (human)

hATM/Phos:2


"A serine-protein kinase ATM phosphorylated 2 in human. This phosphorylated form is observed during mitosis and spindle depolymerization (nocodazole). UniProtKB:Q13315, Ser-1403/Ser-1981, MOD:00046." [PMID:22099307, PRO:KER]

Yes

organism-modification



PR:000035452

serine-protein kinase ATM unphosphorylated form (human)

hATM/PhosRes-


"A serine-protein kinase ATM unphosphorylated form in human." [PRO:KER]


organism-modification



PR:000045909

serine-protein kinase ATM phosphorylated 1 (human)

hATM/Phos:1


"A serine-protein kinase ATM (human) that has been phosphorylated at Tyr-370. UniProtKB:Q13315, Tyr-370, MOD:00048." [iPTMnet:Q13315, PMID:25601159]


organism-modification



PR:000046414

serine-protein kinase ATM acetylated 1 (human)

hATM/Ac:1


"A serine-protein kinase ATM (human) that has been post-translationally modified to include N6-acetyllysine at position 3016 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Lys-3016, MOD:00064." [PRO:DNx, Reactome:R-HSA-5682043]


organism-modification



PR:000064028

serine-protein kinase ATM acetylated and phosphorylated 1 (human)

hATM/AcPhos:1


"A serine-protein kinase ATM (human) that has been acetylated on the residue at the position equivalent to Lys-3016 and phosphorylated on the residue at the position equivalent to Ser-1981 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Ser-1981, MOD:00046|Lys-3016, MOD:00064." [PRO:DNx, Reactome:R-HSA-5693527]


organism-modification



PR:000067880

serine-protein kinase ATM methylated 1 (human)

hATM/Me:1


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-987 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-987, MOD:00660." [IEDB_epitope:1006449, PRO:DNx]


organism-modification



PR:000068526

serine-protein kinase ATM methylated 2 (human)

hATM/Me:2


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-1726 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-1726, MOD:00660." [IEDB_epitope:1054725, PRO:DNx]


organism-modification



PR:000068580

serine-protein kinase ATM cysteinylated 1 (human)

hATM/Cyst:1


"A serine-protein kinase ATM (human) that has been cysteinylated on the residue at the position equivalent to Cys-1674 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-1674, MOD:00765." [IEDB_epitope:1626039, PRO:DNx]


organism-modification



PR:000069648

serine-protein kinase ATM deaminated 1 (human)

hATM/Deam:1


"A serine-protein kinase ATM (human) that has been deaminated on the residue at the position equivalent to Gln-355 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Gln-355, MOD:00685." [IEDB_epitope:1981431, PRO:DNx]


organism-modification



PR:000070379

serine-protein kinase ATM cysteinylated 2 (human)

hATM/Cyst:2


"A serine-protein kinase ATM (human) that has been cysteinylated on the residue at the position equivalent to Cys-1168 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-1168, MOD:00765." [IEDB_epitope:1859747, PRO:DNx]


organism-modification



PR:000070631

serine-protein kinase ATM methylated 3 (human)

hATM/Me:3


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-2824 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-2824, MOD:00660." [IEDB_epitope:1057365, PRO:DNx]


organism-modification



PR:000071620

serine-protein kinase ATM methylated 4 (human)

hATM/Me:4


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-489 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-489, MOD:00660." [IEDB_epitope:1025324, PRO:DNx]


organism-modification



PR:000071881

serine-protein kinase ATM phosphorylated 3 (human)

hATM/Phos:3


"A serine-protein kinase ATM (human) that has been phosphorylated on the residue at the position equivalent to Ser-98 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Ser-98, MOD:00046." [IEDB_epitope:1358408, PRO:DNx]


organism-modification



PR:000078947

serine-protein kinase ATM methylated 5 (human)

hATM/Me:5


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-532 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-532, MOD:00660." [IEDB_epitope:1024811, PRO:DNx]


organism-modification



PR:000083733

serine-protein kinase ATM methylated 6 (human)

hATM/Me:6


"A serine-protein kinase ATM (human) that has been methylated on the residue at the position equivalent to Cys-2159 of the amino acid sequence represented by UniProtKB:Q13315. UniProtKB:Q13315, Cys-2159, MOD:00660." [IEDB_epitope:1046677, IEDB_epitope:1046678, PRO:DNx]


organism-gene



PR:Q5EAK6

serine/threonine-protein kinase ATM (fruit fly)

fly-ATM


"A serine-protein kinase ATM that is encoded in the genome of fruit fly." [PRO:DNx]


organism-gene



PR:Q62388

serine-protein kinase ATM (mouse)

mATM


"A serine-protein kinase ATM that is encoded in the genome of mouse." [OMA:Q62388, PRO:DNx]


organism-modification



PR:000082002

serine-protein kinase ATM cysteinylated 1 (mouse)

mATM/Cyst:1


"A serine-protein kinase ATM (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-2295 of the amino acid sequence represented by UniProtKB:Q62388. UniProtKB:Q62388, Cys-2295, MOD:00765." [IEDB_epitope:2105200, PRO:DNx]


sequence



PR:000026201

serine-protein kinase ATM isoform 1

ATM/iso:1


"A serine-protein kinase ATM that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13315-1 or a 1:1 ortholog thereof." [PRO:CNx]


organism-sequence



PR:Q13315-1

serine-protein kinase ATM isoform 1 (human)

hATM/iso:1


"A serine-protein kinase ATM isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026217

serine-protein kinase ATM isoform 1 phosphorylated 1 (human)

hATM/iso:1/Phos:1


"A serine-protein kinase ATM isoform 1 phosphorylated 1 in human. UniProtKB:Q13315-1, Ser-1981, MOD:00046." [PRO:CNx]


modification



PR:000026203

serine-protein kinase ATM isoform 1 phosphorylated 1

ATM/iso:1/Phos:1


"A serine-protein kinase ATM isoform 1 that has been phosphorylated by autocatalysis following irradiation. Example: UniProtKB:Q13315-1, Ser-1981, MOD:00046." [PRO:CNx]


organism-modification



PR:000026217

serine-protein kinase ATM isoform 1 phosphorylated 1 (human)

hATM/iso:1/Phos:1


"A serine-protein kinase ATM isoform 1 phosphorylated 1 in human. UniProtKB:Q13315-1, Ser-1981, MOD:00046." [PRO:CNx]


modification



PR:000035422

serine-protein kinase ATM phosphorylated 2

ATM/Phos:2


"A serine-protein kinase ATM that has been phosphorylated after mitosis activation. Example: UniProtKB:Q13315, Ser-1403/Ser-1981, MOD:00046." [PMID:22099307, PRO:KER]


organism-modification



PR:000035423

serine-protein kinase ATM phosphorylated 2 (human)

hATM/Phos:2


"A serine-protein kinase ATM phosphorylated 2 in human. This phosphorylated form is observed during mitosis and spindle depolymerization (nocodazole). UniProtKB:Q13315, Ser-1403/Ser-1981, MOD:00046." [PMID:22099307, PRO:KER]

Yes

modification



PR:000035451

serine-protein kinase ATM unphosphorylated form

ATM/PhosRes-


"A serine-protein kinase ATM that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000035452

serine-protein kinase ATM unphosphorylated form (human)

hATM/PhosRes-


"A serine-protein kinase ATM unphosphorylated form in human." [PRO:KER]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035423 hATM/Phos:2
UniProtKB:Q13315, Ser-1403/Ser-1981, MOD:00046
acts_upstream_of_or_withinincreased GO:0031577 spindle checkpoint signaling relative to PR:000035452 hATM/PhosRes- PMID:22099307
enablesincreased GO:0004672 protein kinase activity relative to PR:000035452 hATM/PhosRes- PMID:22099307
located_inGO:0000779 condensed chromosome, centromeric region PMID:22099307
GO:0000922 spindle pole PMID:22099307
GO:0005694 chromosome PMID:22099307
GO:0030496 midbody PMID:22099307
GO:0051233 spindle midzone PMID:22099307
PR:Q13315 hATM enablesGO:0004672 protein kinase activity PMID:22071147