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Protein Ontology report - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
PR:000004195 - http://purl.obolibrary.org/obo/PR_000004195
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004195   
  PRO nameArf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 
  Synonyms
PRO-Short-label: EXACT:ARAP3
Gene-based: RELATED:CENTD3 | Drag1 | Kiaa4097
Other: EXACT:Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | centaurin-delta-3 | Cnt-d3 | dual specificity Rho- and Arf-GTPase-activating protein 1
  Definition"A protein that is a translation product of the human ARAP3 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000004195

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

ARAP3


"A protein that is a translation product of the human ARAP3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q8R5G7

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (mouse)

mARAP3


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 that is encoded in the genome of mouse." [OMA:Q8R5G7, PRO:DNx]


organism-sequence



PR:Q8R5G7-1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 (mouse)

mARAP3/iso:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 that is encoded in the genome of mouse." [PMID:15546919, PRO:HJD]

Yes

organism-sequence



PR:Q8R5G7-2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2 (mouse)

mARAP3/iso:2


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5G7-2 that is encoded in the genome of mouse. This forms lack the N-terminal SAM domain (Pfam:PF07647) found in the corresponding isoform 1." [PMID:15546919, PRO:HJD]


organism-sequence



PR:Q8R5G7-3

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform m3 (mouse)

mARAP3/iso:m3


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5G7-3." [PRO:DNx, UniProtKB:Q8R5G7]


organism-modification



PR:000072490

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 cysteinylated 1 (mouse)

mARAP3/Cyst:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-1018 of the amino acid sequence represented by UniProtKB:Q8R5G7-1. Example: UniProtKB:Q8R5G7-1, Cys-1018, MOD:00765." [IEDB_epitope:2099539, PRO:DNx]


organism-gene



PR:Q8WWN8

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (human)

hARAP3


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WWN8]


organism-sequence



PR:Q8WWN8-1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 (human)

hARAP3/iso:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 that is encoded in the genome of human." [PMID:11804589, PRO:CNA, UniProtKB:Q8WWN8]


organism-sequence



PR:Q8WWN8-2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform h2 (human)

hARAP3/iso:h2


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WWN8-2." [PRO:DNx, UniProtKB:Q8WWN8]


organism-modification



PR:000074770

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 methylated 1 (human)

hARAP3/Me:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (human) that has been methylated on the residue at the position equivalent to Cys-203 of the amino acid sequence represented by UniProtKB:Q8WWN8-1. Example: UniProtKB:Q8WWN8-1, Cys-203, MOD:00660." [IEDB_epitope:1021324, PRO:DNx]


organism-modification



PR:000077645

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 acetylated 1 (human)

hARAP3/Ac:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (human) that has been acetylated on the residue at the position equivalent to Lys-296 of the amino acid sequence represented by UniProtKB:Q8WWN8-1. Example: UniProtKB:Q8WWN8-1, Lys-296, MOD:00723." [IEDB_epitope:1794426, PRO:DNx]


organism-modification



PR:000077705

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 cysteinylated 1 (human)

hARAP3/Cyst:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-203 of the amino acid sequence represented by UniProtKB:Q8WWN8-1. Example: UniProtKB:Q8WWN8-1, Cys-203, MOD:00765." [IEDB_epitope:1021323, PRO:DNx]


sequence



PR:000037352

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1

ARAP3/iso:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5G7-1 or a 1:1 ortholog thereof." [PMID:15546919, PRO:HJD]


organism-sequence



PR:Q8R5G7-1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 (mouse)

mARAP3/iso:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 that is encoded in the genome of mouse." [PMID:15546919, PRO:HJD]

Yes

organism-sequence



PR:Q8WWN8-1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 (human)

hARAP3/iso:1


"An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1 that is encoded in the genome of human." [PMID:11804589, PRO:CNA, UniProtKB:Q8WWN8]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8R5G7-1 mARAP3/iso:1 acts_upstream_of_or_withinGO:0008360 regulation of cell shape MGI_ref:3511766; PMID:15546919
GO:0030336 negative regulation of cell migration MGI_ref:3511766; PMID:15546919
GO:0035021 negative regulation of Rac protein signal transduction MGI_ref:3511766; PMID:15546919
GO:0035024 negative regulation of Rho protein signal transduction MGI_ref:3511766; PMID:15546919
located_inGO:0001726 ruffle MGI_ref:3511766; PMID:15546919
GO:0005737 cytoplasm MGI_ref:3511766; PMID:15546919
GO:0030027 lamellipodium MGI_ref:3511766; PMID:15546919