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Protein Ontology report - leukocyte granule-associated proteinase
PR:000003505 - http://purl.obolibrary.org/obo/PR_000003505
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000003505   
  PRO nameleukocyte granule-associated proteinase 
  Definition"A trypsin that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [PMID:11790262, PMID:7952649, PMID:8929545
  PRO Categoryfamily 
  ParentPR:000027795 trypsin
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene10                                                  Organism-Gene 15                                        
         Sequence10                                                  Organism-Sequence 13                                        
         Modification23                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003505

leukocyte granule-associated proteinase

GZMA/iso:1


"A trypsin that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [PMID:11790262, PMID:7952649, PMID:8929545]


gene



PR:000003472

granzyme K

GZMK


"A leukocyte granule-associated proteinase that is a translation product of the human GZMK gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O35205

granzyme K (mouse)

mGZMK


"A granzyme K that is encoded in the genome of mouse." [OMA:O35205, PRO:DNx]


organism-gene



PR:P49863

granzyme K (human)

hGZMK


"A granzyme K that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49863]


organism-sequence



PR:P49863-1

granzyme K isoform 1 (human)

hGZMK/iso:1


"A granzyme K isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000068076

granzyme K phosphorylated 1 (human)

hGZMK/Phos:1


"A granzyme K (human) that has been phosphorylated on the residue at the position equivalent to Ser-161 of the amino acid sequence represented by UniProtKB:P49863. UniProtKB:P49863, Ser-161, MOD:00046." [IEDB_epitope:2148283, PRO:DNx]


organism-gene



PR:P49864

granzyme K (rat)

rGZMK


"A granzyme K that is encoded in the genome of rat." [OMA:P49864, PRO:DNx]


sequence



PR:000003473

granzyme K isoform 1

GZMK/iso:1


"A granzyme K that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49863-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P49863-1

granzyme K isoform 1 (human)

hGZMK/iso:1


"A granzyme K isoform 1 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000018820

granzyme K proteolytic cleavage product

GZMK/ClvPrd


"A granzyme K that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003475

granzyme D

Gzmd


"A leukocyte granule-associated proteinase that is a translation product of the mouse Gzmd gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P11033

granzyme D (mouse)

mGzmd


"A granzyme D that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P11033]


organism-sequence



PR:P11033-1

granzyme D isoform 1 (mouse)

mGzmd/iso:1


"A granzyme D isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000003476

granzyme D isoform 1

Gzmd/iso:1


"A granzyme D that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11033-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P11033-1

granzyme D isoform 1 (mouse)

mGzmd/iso:1


"A granzyme D isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026635

granzyme D isoform 1, signal peptide removed form

Gzmd/iso:1/SigPep-


"A granzyme D isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018822

granzyme D, signal peptide removed form

Gzmd/SigPep-


"A granzyme D that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026635

granzyme D isoform 1, signal peptide removed form

Gzmd/iso:1/SigPep-


"A granzyme D isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018823

granzyme D proteolytic cleavage product

Gzmd/ClvPrd


"A granzyme D that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003478

granzyme G

Gzmg


"A leukocyte granule-associated proteinase that is a translation product of the mouse Gzmg gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P13366

granzyme G (mouse)

mGzmg


"A granzyme G that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P13366]


organism-sequence



PR:P13366-1

granzyme G isoform 1 (mouse)

mGzmg/iso:1


"A granzyme G isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000003479

granzyme G isoform 1

Gzmg/iso:1


"A granzyme G that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13366-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P13366-1

granzyme G isoform 1 (mouse)

mGzmg/iso:1


"A granzyme G isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026722

granzyme G isoform 1, signal peptide removed form

Gzmg/iso:1/SigPep-


"A granzyme G isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018825

granzyme G, signal peptide removed form

Gzmg/SigPep-


"A granzyme G that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026722

granzyme G isoform 1, signal peptide removed form

Gzmg/iso:1/SigPep-


"A granzyme G isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018826

granzyme G proteolytic cleavage product

Gzmg/ClvPrd


"A granzyme G that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003481

granzyme M

GZMM


"A leukocyte granule-associated proteinase that is a translation product of the human GZMM gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P51124

granzyme M (human)

hGZMM


"A granzyme M that is encoded in the genome of human." [PRO:CNA, UniProtKB:P51124]


organism-sequence



PR:P51124-1

granzyme M isoform 1 (human)

hGZMM/iso:1


"A granzyme M isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000076290

granzyme M, mature form (human)

hGZMM/mature


"A granzyme M (human) that has had the signal peptide and propeptide removed. UniProtKB:P51124, 26-257." [PRO:DNx, Reactome:R-HSA-2975823]


sequence



PR:000003482

granzyme M isoform 1

GZMM/iso:1


"A granzyme M that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51124-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P51124-1

granzyme M isoform 1 (human)

hGZMM/iso:1


"A granzyme M isoform 1 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000003484

granzyme E

Gzme


"A leukocyte granule-associated proteinase that is a translation product of the mouse Gzme gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P08884

granzyme E (mouse)

mGzme


"A granzyme E that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P08884]


organism-sequence



PR:P08884-1

granzyme E isoform 1 (mouse)

mGzme/iso:1


"A granzyme E isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000003485

granzyme E isoform 1

Gzme/iso:1


"A granzyme E that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08884-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P08884-1

granzyme E isoform 1 (mouse)

mGzme/iso:1


"A granzyme E isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026595

granzyme E isoform 1, signal peptide removed form

Gzme/iso:1/SigPep-


"A granzyme E isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018828

granzyme E, signal peptide removed form

Gzme/SigPep-


"A granzyme E that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026595

granzyme E isoform 1, signal peptide removed form

Gzme/iso:1/SigPep-


"A granzyme E isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018829

granzyme E proteolytic cleavage product

Gzme/ClvPrd


"A granzyme E that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003487

granzyme C

Gzmc


"A leukocyte granule-associated proteinase that is a translation product of the mouse Gzmc gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P08882

granzyme C (mouse)

mGzmc


"A granzyme C that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P08882]


organism-sequence



PR:P08882-1

granzyme C isoform 1 (mouse)

mGzmc/iso:1


"A granzyme C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q9VAQ2

CG11843, isoform A (fruit fly)

fly-Gzmc


"A granzyme C that is encoded in the genome of fruit fly." [PRO:CNA]


sequence



PR:000003488

granzyme C isoform 1

Gzmc/iso:1


"A granzyme C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08882-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P08882-1

granzyme C isoform 1 (mouse)

mGzmc/iso:1


"A granzyme C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026721

granzyme C isoform 1, signal peptide removed form

Gzmc/iso:1/SigPep-


"A granzyme C isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018831

granzyme C, signal peptide removed form

Gzmc/SigPep-


"A granzyme C that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026721

granzyme C isoform 1, signal peptide removed form

Gzmc/iso:1/SigPep-


"A granzyme C isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018832

granzyme C proteolytic cleavage product

Gzmc/ClvPrd


"A granzyme C that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003490

granzyme H

GZMH


"A leukocyte granule-associated proteinase that is a translation product of the human GZMH gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A8WIQ2

uncharacterized protein, si:ch211-165b19.4 translation product (zebrafish)

z-GZMH


"A granzyme H that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:P20718

granzyme H (human)

hGZMH


"A granzyme H that is encoded in the genome of human." [PRO:CNA, UniProtKB:P20718]


organism-sequence



PR:P20718-1

granzyme H isoform 1 (human)

hGZMH/iso:1


"A granzyme H isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P20718-2

granzyme H isoform h2 (human)

hGZMH/iso:h2


"A granzyme H (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20718-2." [PRO:DNx, UniProtKB:P20718]


organism-sequence



PR:P20718-3

granzyme H isoform h3 (human)

hGZMH/iso:h3


"A granzyme H (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20718-3." [PRO:DNx, UniProtKB:P20718]


organism-modification



PR:000074268

granzyme H, mature form (human)

hGZMH/mature


"A granzyme H (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P20718-1, 21-246." [PRO:DNx, Reactome:R-HSA-2990875]


sequence



PR:000003491

granzyme H isoform 1

GZMH/iso:1


"A granzyme H that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20718-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P20718-1

granzyme H isoform 1 (human)

hGZMH/iso:1


"A granzyme H isoform 1 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000026717

granzyme H isoform 1, signal peptide removed form

GZMH/iso:1/SigPep-


"A granzyme H isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018834

granzyme H, signal peptide removed form

GZMH/SigPep-


"A granzyme H that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026717

granzyme H isoform 1, signal peptide removed form

GZMH/iso:1/SigPep-


"A granzyme H isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000074268

granzyme H, mature form (human)

hGZMH/mature


"A granzyme H (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P20718-1, 21-246." [PRO:DNx, Reactome:R-HSA-2990875]


modification



PR:000018835

granzyme H proteolytic cleavage product

GZMH/ClvPrd


"A granzyme H that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003493

granzyme F

Gzmf


"A leukocyte granule-associated proteinase that is a translation product of the mouse Gzmf gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P08883

granzyme F (mouse)

mGzmf


"A granzyme F that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P08883]


organism-sequence



PR:P08883-1

granzyme F isoform 1 (mouse)

mGzmf/iso:1


"A granzyme F isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000003494

granzyme F isoform 1

Gzmf/iso:1


"A granzyme F that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08883-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P08883-1

granzyme F isoform 1 (mouse)

mGzmf/iso:1


"A granzyme F isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026685

granzyme F isoform 1, signal peptide removed form

Gzmf/iso:1/SigPep-


"A granzyme F isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018837

granzyme F, signal peptide removed form

Gzmf/SigPep-


"A granzyme F that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026685

granzyme F isoform 1, signal peptide removed form

Gzmf/iso:1/SigPep-


"A granzyme F isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018838

granzyme F proteolytic cleavage product

Gzmf/ClvPrd


"A granzyme F that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000003499

granzyme B

GZMB


"A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P10144

granzyme B (human)

hGZMB


"A granzyme B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P10144]


organism-sequence



PR:P10144-1

granzyme B isoform 1 (human)

hGZMB/iso:1


"A granzyme B isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000070174

granzyme B cysteinylated 1 (human)

hGZMB/Cyst:1


"A granzyme B (human) that has been cysteinylated on the residue at the position equivalent to Cys-230 of the amino acid sequence represented by UniProtKB:P10144. UniProtKB:P10144, Cys-230, MOD:00765." [IEDB_epitope:924969, PRO:DNx]


organism-modification



PR:000071760

granzyme B, mature form (human)

hGZMB/mature


"A granzyme B (human) that has had the signal peptide and propeptide removed. UniProtKB:P10144, 21-247." [PRO:DNx, Reactome:R-HSA-55915, Reactome:R-HSA-6807037]


organism-modification



PR:000083570

granzyme B cysteinylated 2 (human)

hGZMB/Cyst:2


"A granzyme B (human) that has been cysteinylated on the residue at the position equivalent to Cys-173 of the amino acid sequence represented by UniProtKB:P10144. UniProtKB:P10144, Cys-173, MOD:00765." [IEDB_epitope:924881, PRO:DNx]


sequence



PR:000003500

granzyme B isoform 1

GZMB/iso:1


"A granzyme B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10144-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P10144-1

granzyme B isoform 1 (human)

hGZMB/iso:1


"A granzyme B isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P18291-1

granzyme B isoform 1 (rat)

rGZMB/iso:1


"A granzyme B isoform 1 that is encoded in the genome of rat." [PRO:CNA]


modification



PR:000026713

granzyme B isoform 1, signal peptide removed form

GZMB/iso:1/SigPep-


"A granzyme B isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026712

granzyme B, signal peptide removed form

GZMB/SigPep-


"A granzyme B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026713

granzyme B isoform 1, signal peptide removed form

GZMB/iso:1/SigPep-


"A granzyme B isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000071760

granzyme B, mature form (human)

hGZMB/mature


"A granzyme B (human) that has had the signal peptide and propeptide removed. UniProtKB:P10144, 21-247." [PRO:DNx, Reactome:R-HSA-55915, Reactome:R-HSA-6807037]


gene



PR:000003502

granzyme A

GZMA


"A leukocyte granule-associated proteinase that is a translation product of the human GZMA gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P11032

granzyme A (mouse)

mGZMA


"A granzyme A that is encoded in the genome of mouse." [OMA:P11032, PRO:DNx]


organism-sequence



PR:P11032-1

granzyme A isoform HF1 (mouse)

mGZMA/iso:HF1


"A granzyme A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P12544

granzyme A (human)

hGZMA


"A granzyme A that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12544]


sequence



PR:000003503

granzyme A isoform 1

GZMA/iso:1


"A granzyme A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11032-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P11032-1

granzyme A isoform HF1 (mouse)

mGZMA/iso:HF1


"A granzyme A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026633

granzyme A isoform 1, signal peptide removed form

GZMA/iso:1/SigPep-


"A granzyme A isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026632

granzyme A, signal peptide removed form

GZMA/SigPep-


"A granzyme A that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026633

granzyme A isoform 1, signal peptide removed form

GZMA/iso:1/SigPep-


"A granzyme A isoform 1 that has had the signal peptide removed." [PRO:DNx]