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Protein Ontology report - E3 SUMO-protein ligase PIAS
PR:000003444 - http://purl.obolibrary.org/obo/PR_000003444
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003444   
  PRO nameE3 SUMO-protein ligase PIAS 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 11                                        
         Sequence4                                                  Organism-Sequence 17                                        
         Modification1                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003444

E3 SUMO-protein ligase PIAS

PIAS2/iso:2





gene



PR:000003436

E3 SUMO-protein ligase PIAS2

PIAS2


"An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS2 gene or a 1:1 ortholog thereof." [MGI:1096566, PRO:HJD]


organism-gene



PR:O75928

E3 SUMO-protein ligase PIAS2 (human)

hPIAS2


"An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of human." [PRO:HJD, UniProtKB:O75928]


organism-sequence



PR:O75928-1

E3 SUMO-protein ligase PIAS2 isoform hPIAS2-beta (human)

hPIAS2/iso:hPIAS2-beta


"An E3 SUMO-protein ligase PIAS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75928-1." [PRO:DNx, UniProtKB:O75928]


organism-sequence



PR:O75928-2

E3 SUMO-protein ligase PIAS2 isoform hPIAS2-alpha (human)

hPIAS2/iso:hPIAS2-alpha


"An E3 SUMO-protein ligase PIAS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75928-2." [PRO:DNx, UniProtKB:O75928]


organism-sequence



PR:O75928-3

E3 SUMO-protein ligase PIAS2 isoform h3 (human)

hPIAS2/iso:h3


"An E3 SUMO-protein ligase PIAS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75928-3." [PRO:DNx, UniProtKB:O75928]


organism-modification



PR:000076505

E3 SUMO-protein ligase PIAS2 cysteinylated 1 (human)

hPIAS2/Cyst:1


"An E3 SUMO-protein ligase PIAS2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-192 of the amino acid sequence represented by UniProtKB:O75928-1. Example: UniProtKB:O75928-1, Cys-192, MOD:00765." [IEDB_epitope:1039817, PRO:DNx]


organism-gene



PR:Q6AZ28

E3 SUMO-protein ligase PIAS2 (rat)

rPIAS2


"An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of rat." [OMA:Q6AZ28, PRO:DNx]


organism-gene



PR:Q8C5D8

E3 SUMO-protein ligase PIAS2 (mouse)

mPIAS2


"An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of mouse." [OMA:Q8C5D8, PRO:DNx]


organism-sequence



PR:Q8C5D8-1

E3 SUMO-protein ligase PIAS2 isoform 1 (mouse)

mPIAS2/iso:1


"An E3 SUMO-protein ligase PIAS2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:Q8C5D8-2

E3 SUMO-protein ligase PIAS2 isoform 2 (mouse)

mPIAS2/iso:2


"An E3 SUMO-protein ligase PIAS2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

organism-sequence



PR:Q8C5D8-3

E3 SUMO-protein ligase PIAS2 isoform 3 (mouse)

mPIAS2/iso:3


"An E3 SUMO-protein ligase PIAS2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C5D8-3." [PMID:15489334, PRO:HJD, UniProtKB:Q8C5D8]


organism-sequence



PR:Q8C5D8-4

E3 SUMO-protein ligase PIAS2 isoform 4 (mouse)

mPIAS2/iso:4


"An E3 SUMO-protein ligase PIAS2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C5D8-4." [PMID:16141072, PRO:HJD, UniProtKB:Q8C5D8]


organism-sequence



PR:Q8C5D8-5

E3 SUMO-protein ligase PIAS2 isoform 5 (mouse)

mPIAS2/iso:5


"An E3 SUMO-protein ligase PIAS2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C5D8-5." [PMID:15489334, PRO:HJD, UniProtKB:Q8C5D8]


sequence



PR:000003437

E3 SUMO-protein ligase PIAS2 isoform 1

PIAS2/iso:1


"An E3 SUMO-protein ligase PIAS2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C5D8-1 or a 1:1 ortholog thereof." [PMID:17623776, PRO:HJD]


organism-sequence



PR:Q8C5D8-1

E3 SUMO-protein ligase PIAS2 isoform 1 (mouse)

mPIAS2/iso:1


"An E3 SUMO-protein ligase PIAS2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

Yes

sequence



PR:000003442

E3 SUMO-protein ligase PIAS2 isoform 2

PIAS2/iso:2


"An E3 SUMO-protein ligase PIAS2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C5D8-2 or a 1:1 ortholog thereof." [PMID:11104669, PRO:HJD]


organism-sequence



PR:Q8C5D8-2

E3 SUMO-protein ligase PIAS2 isoform 2 (mouse)

mPIAS2/iso:2


"An E3 SUMO-protein ligase PIAS2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]

Yes

gene



PR:000003445

E3 SUMO-protein ligase PIAS1

PIAS1


"An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O75925

E3 SUMO-protein ligase PIAS1 (human)

hPIAS1


"An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75925]


organism-sequence



PR:O75925-1

E3 SUMO-protein ligase PIAS1 isoform 1 (human)

hPIAS1/iso:1


"An E3 SUMO-protein ligase PIAS1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O75925-2

E3 SUMO-protein ligase PIAS1 isoform h2 (human)

hPIAS1/iso:h2


"An E3 SUMO-protein ligase PIAS1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75925-2." [PRO:DNx, UniProtKB:O75925]


organism-sequence



PR:O75925-3

E3 SUMO-protein ligase PIAS1 isoform h3 (human)

hPIAS1/iso:h3


"An E3 SUMO-protein ligase PIAS1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75925-3." [PRO:DNx, UniProtKB:O75925]


organism-modification



PR:000045613

E3 SUMO-protein ligase PIAS1 phosphorylated 1 (human)

hPIAS1/Phos:1


"An E3 SUMO-protein ligase PIAS1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-522 of the amino acid sequence represented by UniProtKB:O75925-1. Example: UniProtKB:O75925-1, Ser-522, MOD:00046." [iPTMnet:O75925, PMID:23202365]


organism-modification



PR:000066715

E3 SUMO-protein ligase PIAS1 cysteinylated 1 (human)

hPIAS1/Cyst:1


"An E3 SUMO-protein ligase PIAS1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-168 of the amino acid sequence represented by UniProtKB:O75925-1. Example: UniProtKB:O75925-1, Cys-168, MOD:00765." [IEDB_epitope:1588301, PRO:DNx]


organism-modification



PR:000085425

E3 SUMO-protein ligase PIAS1 methylated 1 (human)

hPIAS1/Me:1


"An E3 SUMO-protein ligase PIAS1 (human) that has been methylated on the residue at the position equivalent to Cys-228 of the amino acid sequence represented by UniProtKB:O75925-1. Example: UniProtKB:O75925-1, Cys-228, MOD:00660." [IEDB_epitope:1027752, PRO:DNx]


organism-gene



PR:O88907

E3 SUMO-protein ligase PIAS1 (mouse)

mPIAS1


"An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of mouse." [OMA:O88907, PRO:DNx]


organism-sequence



PR:O88907-1

E3 SUMO-protein ligase PIAS1 isoform 1 (mouse)

mPIAS1/iso:1


"An E3 SUMO-protein ligase PIAS1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000083256

E3 SUMO-protein ligase PIAS1 cysteinylated 1 (mouse)

mPIAS1/Cyst:1


"An E3 SUMO-protein ligase PIAS1 (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-435 of the amino acid sequence represented by UniProtKB:O88907. UniProtKB:O88907, Cys-435, MOD:00765." [IEDB_epitope:2109802, PRO:DNx]


sequence



PR:000038410

E3 SUMO-protein ligase PIAS1 isoform 1

PIAS1/iso:1


"An E3 SUMO-protein ligase PIAS1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75925-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O75925-1

E3 SUMO-protein ligase PIAS1 isoform 1 (human)

hPIAS1/iso:1


"An E3 SUMO-protein ligase PIAS1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O88907-1

E3 SUMO-protein ligase PIAS1 isoform 1 (mouse)

mPIAS1/iso:1


"An E3 SUMO-protein ligase PIAS1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000003446

E3 SUMO-protein ligase PIAS3

PIAS3


"An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O54714

E3 SUMO-protein ligase PIAS3 (mouse)

mPIAS3


"An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of mouse." [OMA:O54714, PRO:DNx]


organism-sequence



PR:O54714-1

E3 SUMO-protein ligase PIAS3 isoform 1 (mouse)

mPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:O54714-2

E3 SUMO-protein ligase PIAS3 isoform m2 (mouse)

mPIAS3/iso:m2


"An E3 SUMO-protein ligase PIAS3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54714-2." [PRO:DNx, UniProtKB:O54714]


organism-sequence



PR:O54714-3

E3 SUMO-protein ligase PIAS3 isoform m3 (mouse)

mPIAS3/iso:m3


"An E3 SUMO-protein ligase PIAS3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54714-3." [PRO:DNx, UniProtKB:O54714]


organism-gene



PR:O70260

E3 SUMO-protein ligase PIAS3 (rat)

rPIAS3


"An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of rat." [OMA:O70260, PRO:DNx]


organism-sequence



PR:O70260-1

E3 SUMO-protein ligase PIAS3 isoform 1 (rat)

rPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q9Y6X2

E3 SUMO-protein ligase PIAS3 (human)

hPIAS3


"An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y6X2]


organism-sequence



PR:Q9Y6X2-1

E3 SUMO-protein ligase PIAS3 isoform 1 (human)

hPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000065662

E3 SUMO-protein ligase PIAS3 glutathionylated 1 (human)

hPIAS3/SGlt:1


"An E3 SUMO-protein ligase PIAS3 (human) that has been glutathionylated on the residue at the position equivalent to Cys-418 of the amino acid sequence represented by UniProtKB:Q9Y6X2. UniProtKB:Q9Y6X2, Cys-418, MOD:00234." [IEDB_epitope:422202, PRO:DNx]


organism-modification



PR:000078329

E3 SUMO-protein ligase PIAS3 methylated 1 (human)

hPIAS3/Me:1


"An E3 SUMO-protein ligase PIAS3 (human) that has been methylated on the residue at the position equivalent to Cys-418 of the amino acid sequence represented by UniProtKB:Q9Y6X2. UniProtKB:Q9Y6X2, Cys-418, MOD:00660." [IEDB_epitope:1002316, PRO:DNx]


organism-modification



PR:000083501

E3 SUMO-protein ligase PIAS3 cysteinylated 1 (human)

hPIAS3/Cyst:1


"An E3 SUMO-protein ligase PIAS3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-418 of the amino acid sequence represented by UniProtKB:Q9Y6X2. UniProtKB:Q9Y6X2, Cys-418, MOD:00765." [IEDB_epitope:924722, PRO:DNx]


sequence



PR:000044314

E3 SUMO-protein ligase PIAS3 isoform 1

PIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6X2-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O54714-1

E3 SUMO-protein ligase PIAS3 isoform 1 (mouse)

mPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:O70260-1

E3 SUMO-protein ligase PIAS3 isoform 1 (rat)

rPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9Y6X2-1

E3 SUMO-protein ligase PIAS3 isoform 1 (human)

hPIAS3/iso:1


"An E3 SUMO-protein ligase PIAS3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


gene



PR:000003447

E3 SUMO-protein ligase PIAS4

PIAS4


"An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:F1R4C4

E3 SUMO-protein ligase PIAS4-A (zebrafish)

z-PIAS4


"An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q8N2W9

E3 SUMO-protein ligase PIAS4 (human)

hPIAS4


"An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8N2W9]


organism-modification



PR:000048765

E3 SUMO-protein ligase PIAS4, initiator methionine removed form (human)

hPIAS4/InitMet-


"An E3 SUMO-protein ligase PIAS4 (human) that has had the initiator methionine removed. UniProtKB:Q8N2W9, 2-510." [PRO:DNx, Reactome:R-HSA-2993789]


organism-modification



PR:000064799

E3 SUMO-protein ligase PIAS4, initiator methionine removed sumoylated 1 (human)

hPIAS4/InitMet-/Sumo:1


"An E3 SUMO-protein ligase PIAS4 (human) that has had the initiator methionine removed and that has been sumoylated on the residue at the position equivalent to Lys-35 of the amino acid sequence represented by UniProtKB:Q8N2W9. UniProtKB:Q8N2W9, 2-510, Lys-35, MOD:01149." [PRO:DNx, Reactome:R-HSA-3968415]


organism-gene



PR:Q9JM05

E3 SUMO-protein ligase PIAS4 (mouse)

mPIAS4


"An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of mouse." [OMA:Q9JM05, PRO:DNx]


modification



PR:000018817

E3 SUMO-protein ligase PIAS4, initiator methionine removed form

PIAS4/InitMet-


"An E3 SUMO-protein ligase PIAS4 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048765

E3 SUMO-protein ligase PIAS4, initiator methionine removed form (human)

hPIAS4/InitMet-


"An E3 SUMO-protein ligase PIAS4 (human) that has had the initiator methionine removed. UniProtKB:Q8N2W9, 2-510." [PRO:DNx, Reactome:R-HSA-2993789]


organism-modification



PR:000064799

E3 SUMO-protein ligase PIAS4, initiator methionine removed sumoylated 1 (human)

hPIAS4/InitMet-/Sumo:1


"An E3 SUMO-protein ligase PIAS4 (human) that has had the initiator methionine removed and that has been sumoylated on the residue at the position equivalent to Lys-35 of the amino acid sequence represented by UniProtKB:Q8N2W9. UniProtKB:Q8N2W9, 2-510, Lys-35, MOD:01149." [PRO:DNx, Reactome:R-HSA-3968415]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8C5D8-1 mPIAS2/iso:1 acts_upstream_of_or_withinGO:0006351 DNA-templated transcription MGI_ref:894957; PMID:9256341
GO:0006357 regulation of transcription by RNA polymerase II MGI_ref:894957; PMID:9256341
GO:0016925 protein sumoylation PMID:15767674
GO:0045667 regulation of osteoblast differentiation MGI_ref:3723333; PMID:17623776
GO:0045893 positive regulation of DNA-templated transcription MGI_ref:3723333; PMID:17623776
enablesGO:0003677 DNA binding MGI_ref:894957; PMID:9256341
GO:0005515 protein binding with PR:P29037 mTBP PMID:16522640
GO:0005515 protein binding PMID:16522640
GO:0019789 SUMO transferase activity PMID:15767674
located_inGO:0005634 nucleus PMID:16522640
GO:0016604 nuclear body MGI_ref:3629292; PMID:16675951
PR:Q8C5D8-2 mPIAS2/iso:2 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:1929027; PMID:11104669
enablesGO:0005515 protein binding with PR:P98078-3 MGI_ref:1929027; PMID:11104669