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Protein Ontology report - HSPH protein
PR:000003413 - http://purl.obolibrary.org/obo/PR_000003413
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003413   
  PRO nameHSPH protein 
  Synonyms
Other: EXACT:atypical Hsp70 protein | heat shock protein, Hsp105 type
  Definition"An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s." [PMID:16688212, PMID:18663603, PMID:7797574
  PRO Categoryfamily 
  ParentPR:000003425 Hsp70 family chaperone
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 14                                        
         Sequence3                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF006397
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003413

HSPH protein

HSPH1/iso:1


"An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s." [PMID:16688212, PMID:18663603, PMID:7797574]


gene



PR:000003410

heat shock protein 105 kDa

HSPH1


"An HSPH protein that is a translation product of the human HSPH1 gene or a 1:1 ortholog thereof." [SWAN:PC]


organism-gene



PR:A4UTN7

heat shock protein 105 kDa (pig)

pig-HSPH1


"A heat shock protein 105 kDa that is encoded in the genome of pig." [PRO:DAN]


organism-gene



PR:Q0IIM3

heat shock protein 105 kDa (cow)

cow-HSPH1


"A heat shock protein 105 kDa that is encoded in the genome of cow." [OMA:Q0IIM3, PRO:DAN]


organism-gene



PR:Q60446

heat shock protein 105 kDa (Chinese hamster)

Cgri-HSPH1


"A heat shock protein 105 kDa that is encoded in the genome of Chinese hamster." [PRO:DAN]


organism-gene



PR:Q61699

heat shock protein 105 kDa (mouse)

mHSPH1


"A heat shock protein 105 kDa that is encoded in the genome of mouse." [OMA:Q61699, PRO:DAN]


organism-sequence



PR:Q61699-1

heat shock protein 105 kDa isoform HSP105-alpha (mouse)

mHSPH1/iso:HSP105-alpha


"A heat shock protein 105 kDa (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61699-1." [PRO:DNx, UniProtKB:Q61699]

Yes

organism-sequence



PR:Q61699-2

heat shock protein 105 kDa isoform HSP105-beta (mouse)

mHSPH1/iso:HSP105-beta


"A heat shock protein 105 kDa (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61699-2." [PRO:DNx, UniProtKB:Q61699]

Yes

organism-gene



PR:Q66HA8

heat shock protein 105 kDa (rat)

rHSPH1


"A heat shock protein 105 kDa that is encoded in the genome of rat." [OMA:Q66HA8, PRO:DAN]


organism-gene



PR:Q92598

heat shock protein 105 kDa (human)

hHSPH1


"A heat shock protein 105 kDa that is encoded in the genome of human." [PRO:DAN]


organism-sequence



PR:Q92598-1

heat shock protein 105 kDa isoform Alpha (human)

hHSPH1/iso:Alpha


"A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q92598-2

heat shock protein 105 kDa isoform Beta (human)

hHSPH1/iso:Beta


"A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q92598-3

heat shock protein 105 kDa isoform h3 (human)

hHSPH1/iso:h3


"A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-3." [PRO:DNx, UniProtKB:Q92598]


organism-sequence



PR:Q92598-4

heat shock protein 105 kDa isoform h4 (human)

hHSPH1/iso:h4


"A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-4." [PRO:DNx, UniProtKB:Q92598]


organism-modification



PR:000067382

heat shock protein 105 kDa deaminated 1 (human)

hHSPH1/Deam:1


"A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Gln-116 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Gln-116, MOD:00685." [IEDB_epitope:1573116, PRO:DNx]


organism-modification



PR:000067413

heat shock protein 105 kDa deaminated 2 (human)

hHSPH1/Deam:2


"A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Asn-96, MOD:00684." [IEDB_epitope:1372559, PRO:DNx]


organism-modification



PR:000070017

heat shock protein 105 kDa methylated 1 (human)

hHSPH1/Me:1


"A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-167 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-167, MOD:00660." [IEDB_epitope:1001801, PRO:DNx]


organism-modification



PR:000072334

heat shock protein 105 kDa methylated 2 (human)

hHSPH1/Me:2


"A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-213, MOD:00660." [IEDB_epitope:1039823, PRO:DNx]


organism-modification



PR:000075309

heat shock protein 105 kDa cysteinylated 1 (human)

hHSPH1/Cyst:1


"A heat shock protein 105 kDa (human) that has been cysteinylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-213, MOD:00765." [IEDB_epitope:999333, PRO:DNx]


organism-modification



PR:000077537

heat shock protein 105 kDa deaminated 3 (human)

hHSPH1/Deam:3


"A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Asn-61 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Asn-61, MOD:00684." [IEDB_epitope:1317930, PRO:DNx]


organism-modification



PR:000085480

heat shock protein 105 kDa methylated 3 (human)

hHSPH1/Me:3


"A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-658 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-658, MOD:00660." [IEDB_epitope:1011891, PRO:DNx]


sequence



PR:000003411

heat shock protein 105 kDa isoform 1

HSPH1/iso:1


"A heat shock protein 105 kDa that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-1 or a 1:1 ortholog thereof." [PMID:9931472, PRO:CNA]


organism-sequence



PR:Q92598-1

heat shock protein 105 kDa isoform Alpha (human)

hHSPH1/iso:Alpha


"A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000003427

heat shock protein 105 kDa isoform 2

HSPH1/iso:2


"A heat shock protein 105 kDa that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-2 or a 1:1 ortholog thereof." [PMID:9931472, PRO:CNA]


organism-sequence



PR:Q92598-2

heat shock protein 105 kDa isoform Beta (human)

hHSPH1/iso:Beta


"A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000003414

heat shock 70 kDa protein 4

HSPA4


"An HSPH protein that is a translation product of the human HSPA4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O88600

heat shock 70 kDa protein 4 (rat)

rHSPA4


"A heat shock 70 kDa protein 4 that is encoded in the genome of rat." [OMA:O88600, PRO:DAN]


organism-sequence



PR:O88600-1

heat shock 70 kDa protein 4 isoform 1 (rat)

rHSPA4/iso:1


"A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P34932

heat shock 70 kDa protein 4 (human)

hHSPA4


"A heat shock 70 kDa protein 4 that is encoded in the genome of human." [PRO:DAN]


organism-sequence



PR:P34932-1

heat shock 70 kDa protein 4 isoform 1 (human)

hHSPA4/iso:1


"A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P34932-2

heat shock 70 kDa protein 4 isoform h2 (human)

hHSPA4/iso:h2


"A heat shock 70 kDa protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-2." [PRO:DNx, UniProtKB:P34932]


organism-modification



PR:000065289

heat shock 70 kDa protein 4 methylated 1 (human)

hHSPA4/Me:1


"A heat shock 70 kDa protein 4 (human) that has been methylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-270, MOD:00660." [IEDB_epitope:1043516, PRO:DNx]


organism-modification



PR:000068334

heat shock 70 kDa protein 4 methylated 2 (human)

hHSPA4/Me:2


"A heat shock 70 kDa protein 4 (human) that has been methylated on the residue at the position equivalent to Cys-779 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-779, MOD:00660." [IEDB_epitope:1052029, IEDB_epitope:1055618, PRO:DNx]


organism-modification



PR:000072069

heat shock 70 kDa protein 4 cysteinylated 1 (human)

hHSPA4/Cyst:1


"A heat shock 70 kDa protein 4 (human) that has been cysteinylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-270, MOD:00765." [IEDB_epitope:1043515, PRO:DNx]


organism-modification



PR:000072631

heat shock 70 kDa protein 4 cysteinylated 2 (human)

hHSPA4/Cyst:2


"A heat shock 70 kDa protein 4 (human) that has been cysteinylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-213, MOD:00765." [IEDB_epitope:1003784, PRO:DNx]


organism-gene



PR:Q61316

heat shock 70 kDa protein 4 (mouse)

mHSPA4


"A heat shock 70 kDa protein 4 that is encoded in the genome of mouse." [OMA:Q61316, PRO:DAN]


sequence



PR:000039317

heat shock 70 kDa protein 4 isoform 1

HSPA4/iso:1


"A heat shock 70 kDa protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O88600-1

heat shock 70 kDa protein 4 isoform 1 (rat)

rHSPA4/iso:1


"A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P34932-1

heat shock 70 kDa protein 4 isoform 1 (human)

hHSPA4/iso:1


"A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


family



PR:000003415

heat shock protein SSE

HSPA4


"An HSPH protein that is a translation product of the yeast SSE1 or SSE2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:CNA, PRO:DAN]


gene



PR:000003416

heat shock protein homolog SSE1

SSE1


"A heat shock protein SSE that is a translation product of the yeast SSE1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P32589

heat shock protein homolog SSE1 (yeast)

ySSE1


"A heat shock protein homolog SSE1 that is encoded in the genome of yeast." [PRO:DNx, UniProtKB:P32589]


gene



PR:000003417

heat shock protein homolog SSE2

SSE2


"A heat shock protein SSE that is a translation product of the yeast SSE2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P32590

heat shock protein homolog SSE2 (yeast)

ySSE2


"A heat shock protein homolog SSE2 that is encoded in the genome of yeast." [PRO:DNx, UniProtKB:P32590]


gene



PR:000008809

heat shock 70 kDa protein 4L

HSPA4L


"An HSPH protein that is a translation product of the human HSPA4L gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O95757

heat shock 70 kDa protein 4L (human)

hHSPA4L


"A heat shock 70 kDa protein 4L that is encoded in the genome of human." [PRO:DAN]


organism-modification



PR:000078739

heat shock 70 kDa protein 4L cysteinylated 1 (human)

hHSPA4L/Cyst:1


"A heat shock 70 kDa protein 4L (human) that has been cysteinylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-270, MOD:00765." [IEDB_epitope:1043678, PRO:DNx]


organism-modification



PR:000078775

heat shock 70 kDa protein 4L methylated 1 (human)

hHSPA4L/Me:1


"A heat shock 70 kDa protein 4L (human) that has been methylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-270, MOD:00660." [IEDB_epitope:1037644, IEDB_epitope:1043679, PRO:DNx]


organism-modification



PR:000084766

heat shock 70 kDa protein 4L methylated 2 (human)

hHSPA4L/Me:2


"A heat shock 70 kDa protein 4L (human) that has been methylated on the residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-376, MOD:00660." [IEDB_epitope:1007298, PRO:DNx]


organism-gene



PR:P48722

heat shock 70 kDa protein 4L (mouse)

mHSPA4L


"A heat shock 70 kDa protein 4L that is encoded in the genome of mouse." [OMA:P48722, PRO:DAN]


organism-sequence



PR:P48722-1

heat shock 70 kDa protein 4L isoform m1 (mouse)

mHSPA4L/iso:m1


"A heat shock 70 kDa protein 4L (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48722-1." [PRO:DNx, UniProtKB:P48722]


organism-sequence



PR:P48722-2

heat shock 70 kDa protein 4L isoform m2 (mouse)

mHSPA4L/iso:m2


"A heat shock 70 kDa protein 4L (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48722-2." [PRO:DNx, UniProtKB:P48722]


organism-gene



PR:P83581

heat shock 70 kDa protein 4L (rat)

rHSPA4L


"A heat shock 70 kDa protein 4L that is encoded in the genome of rat." [OMA:P83581, PRO:DAN]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q61699-1 mHSPH1/iso:HSP105-alpha acts_upstream_of_or_withinGO:1903748 negative regulation of establishment of protein localization to mitochondrion MGI_ref:3688933; PMID:16857185
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide MGI_ref:3822965; PMID:18681888
GO:1903753 negative regulation of p38MAPK cascade MGI_ref:3822965; PMID:18681888
GO:2001234 negative regulation of apoptotic signaling pathway MGI_ref:3688933; PMID:16857185
located_inGO:0005737 cytoplasm MGI_ref:5607133; PMID:17643418
PR:Q61699-2 mHSPH1/iso:HSP105-beta acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:5607132; PMID:19028714
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:5607132; PMID:19028714
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:5607132; PMID:19028714
GO:0061098 positive regulation of protein tyrosine kinase activity MGI_ref:4422145; PMID:19754877
GO:1903748 negative regulation of establishment of protein localization to mitochondrion MGI_ref:3688933; PMID:16857185
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide MGI_ref:3822965; PMID:18681888
GO:1903753 negative regulation of p38MAPK cascade MGI_ref:3822965; PMID:18681888
GO:2001234 negative regulation of apoptotic signaling pathway MGI_ref:3688933; PMID:16857185
located_inGO:0005634 nucleus MGI_ref:5607133; PMID:17643418
GO:0005634 nucleus MGI_ref:5607133; PMID:17643418
GO:0005634 nucleus MGI_ref:5607133; PMID:17643418