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Protein Ontology report - phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
PR:000003302 - http://purl.obolibrary.org/obo/PR_000003302
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003302   
  PRO namephosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 
  Synonyms
PRO-Short-label: EXACT:INPP5D
Gene-based: RELATED:7a33 | SHIP | SHIP1
Other: EXACT:hp51CN | inositol polyphosphate-5-phosphatase D | inositol polyphosphate-5-phosphatase of 145 kDa | p150Ship | SH2 domain-containing inositol 5'-phosphatase 1 | SH2 domain-containing inositol phosphatase 1 | SH2 domain-containing inositol-5'-phosphatase 1 | SHIP-1 | SIP-145
  Definition"A protein that is a translation product of the human INPP5D gene or a 1:1 ortholog thereof." [PRO:HJD] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence6                                                  Organism-Sequence 9                                        
         Modification4                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1455
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003302
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
INPP5D
"A protein that is a translation product of the human INPP5D gene or a 1:1 ortholog thereof." [PRO:HJD]

organism-gene


PR:P97573
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (rat)
rINPP5D
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is encoded in the genome of rat." [OMA:P97573, PRO:DNx]

organism-gene


PR:Q92835
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human)
hINPP5D
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is encoded in the genome of human." [PRO:HJD, UniProtKB:Q92835]

organism-sequence


PR:Q92835-1
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform h1 (human)
hINPP5D/iso:h1
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92835-1." [PRO:DNx, UniProtKB:Q92835]

organism-sequence


PR:Q92835-2
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform h2 (human)
hINPP5D/iso:h2
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92835-2." [PRO:DNx, UniProtKB:Q92835]

organism-sequence


PR:Q92835-3
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform h3 (human)
hINPP5D/iso:h3
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92835-3." [PRO:DNx, UniProtKB:Q92835]

organism-modification


PR:000063670
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 phosphotyrosine form (human)
hINPP5D/PhosTyr+
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:Q92835, MOD:00048." [PRO:DNx, Reactome:R-HSA-9680730]

organism-modification


PR:000065352
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 citrullinated 1 (human)
hINPP5D/Cit:1
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been citrullinated on the residue at the position equivalent to Arg-74 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Arg-74, MOD:00219." [IEDB_epitope:912108, PRO:DNx]

organism-modification


PR:000068185
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 methylated 1 (human)
hINPP5D/Me:1
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been methylated on the residue at the position equivalent to Cys-672 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-672, MOD:00660." [IEDB_epitope:1031029, IEDB_epitope:1035703, PRO:DNx]

organism-modification


PR:000068569
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 methylated 2 (human)
hINPP5D/Me:2
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been methylated on the residue at the position equivalent to Cys-43 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-43, MOD:00660." [IEDB_epitope:1040301, PRO:DNx]

organism-modification


PR:000069783
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 deaminated 1 (human)
hINPP5D/Deam:1
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-1019 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Asn-1019, MOD:00684." [IEDB_epitope:1332970, PRO:DNx]

organism-modification


PR:000071487
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 methylated 3 (human)
hINPP5D/Me:3
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been methylated on the residue at the position equivalent to Cys-819 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-819, MOD:00660." [IEDB_epitope:1009318, PRO:DNx]

organism-modification


PR:000071598
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 cysteinylated 1 (human)
hINPP5D/Cyst:1
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-43 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-43, MOD:00765." [IEDB_epitope:1040300, PRO:DNx]

organism-modification


PR:000075843
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 methylated 4 (human)
hINPP5D/Me:4
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been methylated on the residue at the position equivalent to Cys-49 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-49, MOD:00660." [IEDB_epitope:1032681, PRO:DNx]

organism-modification


PR:000079399
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 methylated 5 (human)
hINPP5D/Me:5
"A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (human) that has been methylated on the residue at the position equivalent to Cys-736 of the amino acid sequence represented by UniProtKB:Q92835-1. Example: UniProtKB:Q92835-1, Cys-736, MOD:00660." [IEDB_epitope:1016259, PRO:DNx]

organism-gene


PR:Q9ES52
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (mouse)
mINPP5D
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is encoded in the genome of mouse." [OMA:Q9ES52, PRO:DNx]

organism-sequence


PR:Q9ES52-1
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1 (mouse)
mINPP5D/iso:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

organism-sequence


PR:Q9ES52-2
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2 (mouse)
mINPP5D/iso:2
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-modification


PR:000036644
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 (mouse)
mINPP5D/iso:2/Phos:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 in mouse." [PMID:8643691, PRO:HJD]
Yes
organism-sequence


PR:Q9ES52-3
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3 (mouse)
mINPP5D/iso:3
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 that is encoded in the genome of mouse." [PRO:HJD]

organism-sequence


PR:Q9ES52-4
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 4 (mouse)
mINPP5D/iso:4
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 4 that is encoded in the genome of mouse." [PRO:HJD]

organism-sequence


PR:Q9ES52-5
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 5 (mouse)
mINPP5D/iso:5
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 5 that is encoded in the genome of mouse." [PRO:HJD]

organism-sequence


PR:Q9ES52-6
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 6 (mouse)
mINPP5D/iso:6
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 6 that is encoded in the genome of mouse." [PRO:HJD]

sequence


PR:000003303
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 1
INPP5D/iso:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-1 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-1
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1 (mouse)
mINPP5D/iso:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]

sequence


PR:000003305
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2
INPP5D/iso:2
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-2 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-2
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2 (mouse)
mINPP5D/iso:2
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]
Yes
organism-modification


PR:000036644
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 (mouse)
mINPP5D/iso:2/Phos:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 in mouse." [PMID:8643691, PRO:HJD]
Yes
modification


PR:000003314
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated form
INPP5D/iso:2/PhosRes+
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003313
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1
INPP5D/iso:2/Phos:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated form that is phosphorylated on Tyr-residues located in the C-terminal Proline rich domain. Example: UniProtKB:Q9ES52-2, MOD:00048." [PMID:8643691, PRO:HJD]

organism-modification


PR:000036644
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 (mouse)
mINPP5D/iso:2/Phos:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 2 phosphorylated 1 in mouse." [PMID:8643691, PRO:HJD]
Yes
sequence


PR:000003307
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3
INPP5D/iso:3
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-3 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-3
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3 (mouse)
mINPP5D/iso:3
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 that is encoded in the genome of mouse." [PRO:HJD]

modification


PR:000003318
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 phosphorylated form
INPP5D/iso:3/PhosRes+
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003319
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 phosphorylated 1
INPP5D/iso:3/Phos:1
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 3 phosphorylated form in which the phosphorylation occurs within the two NPXY motifs present in the C-terminal Proline rich domain." [PMID:10068665, PRO:HJD]

sequence


PR:000003309
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 4
INPP5D/iso:4
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-4 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-4
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 4 (mouse)
mINPP5D/iso:4
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 4 that is encoded in the genome of mouse." [PRO:HJD]

sequence


PR:000003311
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 5
INPP5D/iso:5
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-5 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-5
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 5 (mouse)
mINPP5D/iso:5
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 5 that is encoded in the genome of mouse." [PRO:HJD]

sequence


PR:000003315
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 6
INPP5D/iso:6
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ES52-6 or a 1:1 ortholog thereof." [PRO:HJD]

organism-sequence


PR:Q9ES52-6
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 6 (mouse)
mINPP5D/iso:6
"A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 6 that is encoded in the genome of mouse." [PRO:HJD]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036644 mINPP5D/iso:2/Phos:1 enablesGO:0005515 protein binding with PR:P98083 mSHC1 PMID:8643691
PR:Q9ES52-2 mINPP5D/iso:2 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation MGI_ref:85574; PMID:8890215
enablesGO:0004445 inositol-polyphosphate 5-phosphatase activity MGI_ref:85578; PMID:8643691
GO:0017124 SH3 domain binding MGI_ref:85578; PMID:8643691
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity MGI_ref:85574; PMID:8890215
GO:0051425 PTB domain binding MGI_ref:85577; PMID:8654924