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Protein Ontology report - dual specificity mitogen-activated protein kinase kinase 6
PR:000003282 - http://purl.obolibrary.org/obo/PR_000003282
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000003282   
  PRO namedual specificity mitogen-activated protein kinase kinase 6 
  Synonyms
PRO-Short-label: EXACT:MAP2K6
Gene-based: RELATED:MEK6 | MKK6 | PRKMK6 | SKK3
Other: EXACT:MAP kinase kinase 6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK 6 | SAPKK3
  Definition"A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K6 gene or a 1:1 ortholog thereof." [TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorygene 
  ParentPR:000021990 dual specificity mitogen-activated protein kinase kinase 3/6
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2067
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003282

dual specificity mitogen-activated protein kinase kinase 6

MAP2K6


"A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K6 gene or a 1:1 ortholog thereof." [TLR:AMM]


Yes
organism-gene



PR:P52564

dual specificity mitogen-activated protein kinase kinase 6 (human)

hMAP2K6


"A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human." [TLR:AMM, UniProtKB:P52564]


organism-sequence



PR:P52564-1

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (human)

hMAP2K6/iso:1


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P52564-2

dual specificity mitogen-activated protein kinase kinase 6 isoform h2 (human)

hMAP2K6/iso:h2


"A dual specificity mitogen-activated protein kinase kinase 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52564-2." [PRO:DNx, UniProtKB:P52564]


organism-modification



PR:000045822

dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 1 (human)

hMAP2K6/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 6 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-219 of the amino acid sequence represented by UniProtKB:P52564-1. Example: UniProtKB:P52564-1, Tyr-219, MOD:00048." [iPTMnet:P52564, PMID:17854274]


organism-modification



PR:000048299

dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 2 (human)

hMAP2K6/Phos:2


"A dual specificity mitogen-activated protein kinase kinase 6 (human) that has been phosphorylated on the residue at the position equivalent to Ser-207, and phosphothreonine at position 211 of the amino acid sequence represented by UniProtKB:P52564. UniProtKB:P52564, Ser-207, MOD:00046|Thr-211, MOD:00047." [PRO:DNx, Reactome:R-HSA-206255, Reactome:R-HSA-450258]


organism-modification



PR:000068145

dual specificity mitogen-activated protein kinase kinase 6 deaminated 1 (human)

hMAP2K6/Deam:1


"A dual specificity mitogen-activated protein kinase kinase 6 (human) that has been deaminated on the residue at the position equivalent to Gln-310 of the amino acid sequence represented by UniProtKB:P52564-1. Example: UniProtKB:P52564-1, Gln-310, MOD:00685." [IEDB_epitope:929050, PRO:DNx]


organism-gene



PR:P70236

dual specificity mitogen-activated protein kinase kinase 6 (mouse)

mMAP2K6


"A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of mouse." [OMA:P70236, PRO:DNx]


organism-sequence



PR:P70236-1

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (mouse)

mMAP2K6/iso:1


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q9DGE0

dual specificity mitogen-activated protein kinase kinase 6 (zebrafish)

z-MAP2K6


"A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of zebrafish." [TLR:AMM]


sequence



PR:000021979

dual specificity mitogen-activated protein kinase kinase 6 isoform 1

MAP2K6/iso:1


"A dual specificity mitogen-activated protein kinase kinase 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52564-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P52564-1

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (human)

hMAP2K6/iso:1


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P70236-1

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (mouse)

mMAP2K6/iso:1


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000021980

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 unmodified form

MAP2K6/iso:1/UnMod


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]


Yes
modification



PR:000021992

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form

MAP2K6/iso:1/PhosRes+


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


Yes
modification



PR:000021981

dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated 1

MAP2K6/iso:1/Phos:1


"A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form in which the phosphorylation occurs in the activation loop by ubiquitinated TAK1. Example: UniProtKB:P52564-1, Ser-207, MOD:00046|Thr-211, MOD:00047." [PMID:11460167, TLR:AMM]


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MAP2K6 forms found in complexes   

MAP2K6 Component
Complexes
PR:000003282 MAP2K6 PR:000027079 TAK1 kinase-MKK6 complex
PR:000021980 MAP2K6/iso:1/UnMod PR:000027080 TAK1 kinase-MKK6 complex 1
PR:000021992 MAP2K6/iso:1/PhosRes+ PR:000027081 TAK1 kinase-MKK6 complex 2