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family
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PR:000003177 |
shc-transforming protein
|
TGFBR2/iso:RII-1/SigPep-/Phos:1
|
"A protein that is a translation product of the human SHC1, SHC2, SHC3 or SHC4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The canonical protein sequence has a core domain architecture consisting of a copy of the Phosphotyrosine interaction domain (PTB/PID) (Pfam:PF00640) and a copy of the SH2 domain (Pfam:PF00017) towards the C-terminus." [PRO:CNA, PRO:DAN]
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gene
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PR:000003178 |
shc-transforming protein 1
|
SHC1
|
"An shc-transforming protein that is a translation product of the human SHC1 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:P29353 |
SHC-transforming protein 1 (human)
|
hSHC1
|
"An shc-transforming protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29353]
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organism-sequence
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PR:P29353-1 |
SHC-transforming protein 1 isoform p66Shc (human)
|
hSHC1/iso:p66Shc
|
"An shc-transforming protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
|
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PR:000062560 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 1 (human)
|
hSHC1/iso:p66Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Ser-139, Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Ser-139, MOD:00046|Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-8934452]
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organism-modification
|
|
PR:000085896 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 2 (human)
|
hSHC1/iso:p66Shc/Phos:2
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-2404176]
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organism-sequence
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PR:P29353-2 |
SHC-transforming protein 1 isoform p52Shc (human)
|
hSHC1/iso:p52Shc
|
"An shc-transforming protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
|
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PR:000061010 |
SHC-transforming protein 1 isoform p52Shc phosphorylated 1 (human)
|
hSHC1/iso:p52Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p52Shc (human) that has been phosphorylated on the residue at the position equivalent to Tyr-317 of the amino acid sequence represented by UniProtKB:P29353-2. UniProtKB:P29353-2, Tyr-317, MOD:00048." [PRO:DNx, Reactome:R-HSA-8851895]
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organism-sequence
|
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PR:P29353-3 |
SHC-transforming protein 1 isoform p46Shc (human)
|
hSHC1/iso:p46Shc
|
"An shc-transforming protein 1 isoform 3 that is encoded in the genome of human." [PRO:CNA]
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organism-sequence
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PR:P29353-5 |
SHC-transforming protein 1 isoform h5 (human)
|
hSHC1/iso:h5
|
"An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-5." [PRO:DNx, UniProtKB:P29353]
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organism-sequence
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PR:P29353-6 |
SHC-transforming protein 1 isoform h6 (human)
|
hSHC1/iso:h6
|
"An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-6." [PRO:DNx, UniProtKB:P29353]
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organism-sequence
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PR:P29353-7 |
SHC-transforming protein 1 isoform h7 (human)
|
hSHC1/iso:h7
|
"An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-7." [PRO:DNx, UniProtKB:P29353]
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organism-modification
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PR:000049233 |
SHC-transforming protein 1 phosphotyrosine form (human)
|
hSHC1/PhosTyr+
|
"An SHC-transforming protein 1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P29353, MOD:00048." [PRO:DNx, Reactome:R-HSA-162568]
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organism-modification
|
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PR:000049230 |
SHC-transforming protein 1 phosphorylated 1 (human)
|
hSHC1/Phos:1
|
"An SHC-transforming protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 349 and 350 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-349/Tyr-350, MOD:00048." [PRO:DNx, Reactome:R-HSA-180276]
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organism-modification
|
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PR:000049231 |
SHC-transforming protein 1 phosphorylated 2 (human)
|
hSHC1/Phos:2
|
"An SHC-transforming protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 349, 350 and 427 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-912321]
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organism-modification
|
|
PR:000049232 |
SHC-transforming protein 1 phosphorylated 3 (human)
|
hSHC1/Phos:3
|
"An SHC-transforming protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-427 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-74684]
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organism-modification
|
|
PR:000061010 |
SHC-transforming protein 1 isoform p52Shc phosphorylated 1 (human)
|
hSHC1/iso:p52Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p52Shc (human) that has been phosphorylated on the residue at the position equivalent to Tyr-317 of the amino acid sequence represented by UniProtKB:P29353-2. UniProtKB:P29353-2, Tyr-317, MOD:00048." [PRO:DNx, Reactome:R-HSA-8851895]
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organism-modification
|
|
PR:000062560 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 1 (human)
|
hSHC1/iso:p66Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Ser-139, Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Ser-139, MOD:00046|Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-8934452]
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organism-modification
|
|
PR:000085896 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 2 (human)
|
hSHC1/iso:p66Shc/Phos:2
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-2404176]
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organism-gene
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PR:P98083 |
SHC-transforming protein 1 (mouse)
|
mSHC1
|
"An shc-transforming protein 1 that is encoded in the genome of mouse." [OMA:P98083, PRO:DNx]
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organism-sequence
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|
PR:P98083-1 |
SHC-transforming protein 1 isoform p66Shc (mouse)
|
mSHC1/iso:p66Shc
|
"An shc-transforming protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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| |
organism-sequence
|
|
PR:P98083-2 |
SHC-transforming protein 1 isoform p52Shc (mouse)
|
mSHC1/iso:p52Shc
|
"An shc-transforming protein 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
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organism-sequence
|
|
PR:P98083-3 |
SHC-transforming protein 1 isoform p47Shc (mouse)
|
mSHC1/iso:p47Shc
|
"An shc-transforming protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]
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organism-gene
|
|
PR:Q5M824 |
SHC-transforming protein 1 (rat)
|
rSHC1
|
"An shc-transforming protein 1 that is encoded in the genome of rat." [OMA:Q5M824, PRO:DNx]
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| | | |
sequence
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PR:000003182 |
shc-transforming protein 1 isoform 1
|
SHC1/iso:1
|
"An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-1 or a 1:1 ortholog thereof." [PMID:11948181, PRO:CNA]
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| |
organism-sequence
|
|
PR:P29353-1 |
SHC-transforming protein 1 isoform p66Shc (human)
|
hSHC1/iso:p66Shc
|
"An shc-transforming protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
|
|
PR:000062560 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 1 (human)
|
hSHC1/iso:p66Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Ser-139, Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Ser-139, MOD:00046|Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-8934452]
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organism-modification
|
|
PR:000085896 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 2 (human)
|
hSHC1/iso:p66Shc/Phos:2
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-2404176]
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| |
organism-sequence
|
|
PR:P98083-1 |
SHC-transforming protein 1 isoform p66Shc (mouse)
|
mSHC1/iso:p66Shc
|
"An shc-transforming protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
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| |
modification
|
|
PR:000003186 |
shc-transforming protein 1 isoform 1 phosphorylated form
|
SHC1/iso:1/PhosRes+
|
"An shc-transforming protein 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
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modification
|
|
PR:000003187 |
shc-transforming protein 1 isoform 1 phosphorylated 1
|
SHC1/iso:1/Phos:1
|
"An shc-transforming protein 1 isoform 1 phosphorylated form in which the phosphorylation occurs at Ser and Tyr residues by the action of activated TGF beta receptor type 1." [PID:SHC, PMID:17673906]
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organism-modification
|
|
PR:000062560 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 1 (human)
|
hSHC1/iso:p66Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Ser-139, Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Ser-139, MOD:00046|Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-8934452]
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organism-modification
|
|
PR:000085896 |
SHC-transforming protein 1 isoform p66Shc phosphorylated 2 (human)
|
hSHC1/iso:p66Shc/Phos:2
|
"An SHC-transforming protein 1 isoform p66Shc (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-349, Tyr-350, and Tyr-427 of the amino acid sequence represented by UniProtKB:P29353-1. UniProtKB:P29353-1, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-2404176]
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| | | |
sequence
|
|
PR:000003183 |
shc-transforming protein 1 isoform 2
|
SHC1/iso:2
|
"An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-2 or a 1:1 ortholog thereof." [PRO:CNA]
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| |
organism-sequence
|
|
PR:P29353-2 |
SHC-transforming protein 1 isoform p52Shc (human)
|
hSHC1/iso:p52Shc
|
"An shc-transforming protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
|
|
PR:000061010 |
SHC-transforming protein 1 isoform p52Shc phosphorylated 1 (human)
|
hSHC1/iso:p52Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p52Shc (human) that has been phosphorylated on the residue at the position equivalent to Tyr-317 of the amino acid sequence represented by UniProtKB:P29353-2. UniProtKB:P29353-2, Tyr-317, MOD:00048." [PRO:DNx, Reactome:R-HSA-8851895]
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| |
organism-sequence
|
|
PR:P98083-2 |
SHC-transforming protein 1 isoform p52Shc (mouse)
|
mSHC1/iso:p52Shc
|
"An shc-transforming protein 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
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| |
modification
|
|
PR:000003189 |
shc-transforming protein 1 isoform 2 phosphorylated form
|
SHC1/iso:2/PhosRes+
|
"An shc-transforming protein 1 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]
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modification
|
|
PR:000003190 |
shc-transforming protein 1 isoform 2 phosphorylated 1
|
SHC1/iso:2/Phos:1
|
"An shc-transforming protein 1 isoform 2 phosphorylated form in which the phosphorylation occurs at Ser and Tyr residues by the action of activated TGF beta receptor type 1." [PID:SHC, PMID:17673906]
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organism-modification
|
|
PR:000061010 |
SHC-transforming protein 1 isoform p52Shc phosphorylated 1 (human)
|
hSHC1/iso:p52Shc/Phos:1
|
"An SHC-transforming protein 1 isoform p52Shc (human) that has been phosphorylated on the residue at the position equivalent to Tyr-317 of the amino acid sequence represented by UniProtKB:P29353-2. UniProtKB:P29353-2, Tyr-317, MOD:00048." [PRO:DNx, Reactome:R-HSA-8851895]
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| | | |
sequence
|
|
PR:000003184 |
shc-transforming protein 1 isoform 3
|
SHC1/iso:3
|
"An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-3 or a 1:1 ortholog thereof." [PRO:CNA]
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| |
organism-sequence
|
|
PR:P29353-3 |
SHC-transforming protein 1 isoform p46Shc (human)
|
hSHC1/iso:p46Shc
|
"An shc-transforming protein 1 isoform 3 that is encoded in the genome of human." [PRO:CNA]
|
|
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|
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| |
organism-sequence
|
|
PR:P98083-3 |
SHC-transforming protein 1 isoform p47Shc (mouse)
|
mSHC1/iso:p47Shc
|
"An shc-transforming protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA]
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gene
|
|
PR:000003179 |
SHC-transforming protein 4
|
SHC4
|
"An shc-transforming protein that is a translation product of the human SHC4 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
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| | | |
organism-gene
|
|
PR:Q6S5L8 |
SHC-transforming protein 4 (human)
|
hSHC4
|
"An SHC-transforming protein 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q6S5L8]
|
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| |
organism-sequence
|
|
PR:Q6S5L8-1 |
SHC-transforming protein 4 isoform h1 (human)
|
hSHC4/iso:h1
|
"An SHC-transforming protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6S5L8-1." [PRO:DNx, UniProtKB:Q6S5L8]
|
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| |
organism-sequence
|
|
PR:Q6S5L8-2 |
SHC-transforming protein 4 isoform h2 (human)
|
hSHC4/iso:h2
|
"An SHC-transforming protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6S5L8-2." [PRO:DNx, UniProtKB:Q6S5L8]
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| | | |
organism-gene
|
|
PR:Q6S5L9 |
SHC-transforming protein 4 (mouse)
|
mSHC4
|
"An SHC-transforming protein 4 that is encoded in the genome of mouse." [OMA:Q6S5L9, PRO:DNx]
|
|
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gene
|
|
PR:000003180 |
SHC-transforming protein 2
|
SHC2
|
"An shc-transforming protein that is a translation product of the human SHC2 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
|
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| | | |
organism-gene
|
|
PR:O70142 |
SHC-transforming protein 2 (rat)
|
rSHC2
|
"An SHC-transforming protein 2 that is encoded in the genome of rat." [OMA:O70142, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | |
organism-gene
|
|
PR:P98077 |
SHC-transforming protein 2 (human)
|
hSHC2
|
"An SHC-transforming protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P98077]
|
|
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|
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|
| | | | | | | | |
| |
organism-modification
|
|
PR:000049234 |
SHC-transforming protein 2 phosphotyrosine form (human)
|
hSHC2/PhosTyr+
|
"An SHC-transforming protein 2 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P98077, MOD:00048." [PRO:DNx, Reactome:R-HSA-167051]
|
|
|
|
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| | | | | | |
| | | |
organism-gene
|
|
PR:Q8BMC3 |
SHC-transforming protein 2 (mouse)
|
mSHC2
|
"An SHC-transforming protein 2 that is encoded in the genome of mouse." [OMA:Q8BMC3, PRO:DNx]
|
|
|
|
|
|
|
| | | | |
| | | | | |
gene
|
|
PR:000003181 |
SHC-transforming protein 3
|
SHC3
|
"An shc-transforming protein that is a translation product of the human SHC3 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | |
| | | |
organism-gene
|
|
PR:O70143 |
SHC-transforming protein 3 (rat)
|
rSHC3
|
"An SHC-transforming protein 3 that is encoded in the genome of rat." [OMA:O70143, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| |
organism-sequence
|
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PR:O70143-1 |
SHC-transforming protein 3 isoform rp66 (rat)
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rSHC3/iso:rp66
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"An SHC-transforming protein 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O70143-1." [PRO:DNx, UniProtKB:O70143]
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organism-sequence
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PR:O70143-2 |
SHC-transforming protein 3 isoform rp52 (rat)
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rSHC3/iso:rp52
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"An SHC-transforming protein 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O70143-2." [PRO:DNx, UniProtKB:O70143]
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organism-gene
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PR:Q61120 |
SHC-transforming protein 3 (mouse)
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mSHC3
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"An SHC-transforming protein 3 that is encoded in the genome of mouse." [OMA:Q61120, PRO:DNx]
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organism-gene
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PR:Q92529 |
SHC-transforming protein 3 (human)
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hSHC3
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"An SHC-transforming protein 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q92529]
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organism-sequence
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PR:Q92529-1 |
SHC-transforming protein 3 isoform hp64 (human)
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hSHC3/iso:hp64
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"An SHC-transforming protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92529-1." [PRO:DNx, UniProtKB:Q92529]
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organism-sequence
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PR:Q92529-2 |
SHC-transforming protein 3 isoform hp52 (human)
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hSHC3/iso:hp52
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"An SHC-transforming protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92529-2." [PRO:DNx, UniProtKB:Q92529]
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organism-modification
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PR:000049235 |
SHC-transforming protein 3 phosphotyrosine form (human)
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hSHC3/PhosTyr+
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"An SHC-transforming protein 3 (human) that includes at least one phosphorylated tyrosine. UniProtKB:Q92529, MOD:00048." [PRO:DNx, Reactome:R-HSA-3009043]
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