back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TRAF family member-associated NF-kappa-B activator
PR:000003146 - http://purl.obolibrary.org/obo/PR_000003146
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000003146   
  PRO nameTRAF family member-associated NF-kappa-B activator 
  Synonyms
PRO-Short-label: EXACT:TANK
Gene-based: RELATED:ITRAF | TRAF2
Other: EXACT:I-TRAF
  Definition"A protein that is a translation product of the human TANK gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003146
TRAF family member-associated NF-kappa-B activator
TANK
"A protein that is a translation product of the human TANK gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P70347
TRAF family member-associated NF-kappa-B activator (mouse)
mTANK
"A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of mouse." [OMA:P70347, PRO:CNA]

Yes
organism-sequence


PR:P70347-1
TRAF family member-associated NF-kappa-B activator isoform 1 (mouse)
mTANK/iso:1
"A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036091
TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form (mouse)
mTANK/iso:1/K63polyUbiq+
"A TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form in mouse. UniProtKB:P70347-1, PR:000044772." [TLR:AMM]

Yes
organism-sequence


PR:P70347-2
TRAF family member-associated NF-kappa-B activator isoform m2 (mouse)
mTANK/iso:m2
"A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-2." [PRO:DNx, UniProtKB:P70347]

organism-sequence


PR:P70347-3
TRAF family member-associated NF-kappa-B activator isoform m3 (mouse)
mTANK/iso:m3
"A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-3." [PRO:DNx, UniProtKB:P70347]

organism-sequence


PR:P70347-4
TRAF family member-associated NF-kappa-B activator isoform m4 (mouse)
mTANK/iso:m4
"A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-4." [PRO:DNx, UniProtKB:P70347]

organism-gene


PR:Q92844
TRAF family member-associated NF-kappa-B activator (human)
hTANK
"A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q92844]

organism-sequence


PR:Q92844-1
TRAF family member-associated NF-kappa-B activator isoform Long (human)
hTANK/iso:Long
"A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:Q92844-2
TRAF family member-associated NF-kappa-B activator isoform Short (human)
hTANK/iso:Short
"A TRAF family member-associated NF-kappa-B activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92844-2." [PRO:DNx, UniProtKB:Q92844]

organism-sequence


PR:Q92844-3
TRAF family member-associated NF-kappa-B activator isoform h3 (human)
hTANK/iso:h3
"A TRAF family member-associated NF-kappa-B activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92844-3." [PRO:DNx, UniProtKB:Q92844]

organism-modification


PR:000049397
TRAF family member-associated NF-kappa-B activator ubiquitinated form (human)
hTANK/UbiqLys+
"A TRAF family member-associated NF-kappa-B activator (human) that includes at least one ubiquitinated lysine. UniProtKB:Q92844, MOD:01148." [PRO:DNx, Reactome:R-HSA-5362480]

sequence


PR:000003193
TRAF family member-associated NF-kappa-B activator isoform 1
TANK/iso:1
"A TRAF family member-associated NF-kappa-B activator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P70347-1
TRAF family member-associated NF-kappa-B activator isoform 1 (mouse)
mTANK/iso:1
"A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036091
TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form (mouse)
mTANK/iso:1/K63polyUbiq+
"A TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form in mouse. UniProtKB:P70347-1, PR:000044772." [TLR:AMM]

Yes
organism-sequence


PR:Q92844-1
TRAF family member-associated NF-kappa-B activator isoform Long (human)
hTANK/iso:Long
"A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of human." [PRO:CNA]

modification


PR:000003195
TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated form
TANK/iso:1/PhosUbiq+
"A TRAF family member-associated NF-kappa-B activator isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000003196
TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated 1
TANK/iso:1/PhosUbiq:1
"A TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated by TBK1-IKKE upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKE-mediated Lys-63-linked polyubiquitination, a mechanism that does not require TBK1-IKKE kinase activity." [PMID:17823124, TLR:AMM]

modification


PR:000003300
TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form
TANK/iso:1/K63polyUbiq+
"A TRAF family member-associated NF-kappa-B activator isoform 1 that has K63-linked polyubiquitin. Example: UniProtKB:Q92844-1, PR:000044772." [PRO:CNA, TLR:AMM]

organism-modification


PR:000036091
TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form (mouse)
mTANK/iso:1/K63polyUbiq+
"A TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form in mouse. UniProtKB:P70347-1, PR:000044772." [TLR:AMM]

Yes
Back to top
TANK forms found in complexes   

TANK Component
 Complexes
PR:000036091 mTANK/iso:1/K63polyUbiq+ PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:P70347 mTANK PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036149 tbk1:tank:ikke complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)