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Protein Ontology report - NFAT protein
PR:000003112 - http://purl.obolibrary.org/obo/PR_000003112
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003112   
  PRO nameNFAT protein 
  Definition"A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 13                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003112

NFAT protein

TGFBR3/iso:1


"A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833)." [PRO:WCB]


gene



PR:000003113

nuclear factor of activated T-cells, cytoplasmic 1

NFATC1


"An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O88942

nuclear factor of activated T-cells, cytoplasmic 1 (mouse)

mNFATC1


"A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of mouse." [OMA:O88942, PRO:DNx]


organism-sequence



PR:O88942-1

nuclear factor of activated T-cells, cytoplasmic 1 isoform Alpha (mouse)

mNFATC1/iso:Alpha


"A nuclear factor of activated T-cells, cytoplasmic 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88942-1." [PRO:DNx, UniProtKB:O88942]


organism-sequence



PR:O88942-2

nuclear factor of activated T-cells, cytoplasmic 1 isoform Beta (mouse)

mNFATC1/iso:Beta


"A nuclear factor of activated T-cells, cytoplasmic 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88942-2." [PRO:DNx, UniProtKB:O88942]


organism-sequence



PR:O88942-3

nuclear factor of activated T-cells, cytoplasmic 1 isoform Alpha' (mouse)

mNFATC1/iso:Alpha'


"A nuclear factor of activated T-cells, cytoplasmic 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88942-3." [PRO:DNx, UniProtKB:O88942]


organism-gene



PR:O95644

nuclear factor of activated T-cells, cytoplasmic 1 (human)

hNFATC1


"A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O95644]


organism-sequence



PR:O95644-1

nuclear factor of activated T-cells, cytoplasmic 1 isoform C-alpha (human)

hNFATC1/iso:C-alpha


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

organism-modification



PR:000036638

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 (human)

hNFATC1/iso:1/Phos:1


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 in human. UniProtKB:O95644-1, Ser-117/Ser-172, MOD:00046." [PMID:10866678, PRO:JAN]

Yes

organism-sequence



PR:O95644-10

nuclear factor of activated T-cells, cytoplasmic 1 isoform IA-deltaIX (human)

hNFATC1/iso:IA-deltaIX


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-10." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-11

nuclear factor of activated T-cells, cytoplasmic 1 isoform IB-deltaIX (human)

hNFATC1/iso:IB-deltaIX


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-11." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-17

nuclear factor of activated T-cells, cytoplasmic 1 isoform h10 (human)

hNFATC1/iso:h10


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-17." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-2

nuclear factor of activated T-cells, cytoplasmic 1 isoform A-alpha (human)

hNFATC1/iso:A-alpha


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-2." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-3

nuclear factor of activated T-cells, cytoplasmic 1 isoform A-beta (human)

hNFATC1/iso:A-beta


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-3." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-4

nuclear factor of activated T-cells, cytoplasmic 1 isoform B-alpha (human)

hNFATC1/iso:B-alpha


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-4." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-5

nuclear factor of activated T-cells, cytoplasmic 1 isoform B-beta (human)

hNFATC1/iso:B-beta


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-5." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-6

nuclear factor of activated T-cells, cytoplasmic 1 isoform C-beta (human)

hNFATC1/iso:C-beta


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-6." [PRO:DNx, UniProtKB:O95644]


organism-sequence



PR:O95644-8

nuclear factor of activated T-cells, cytoplasmic 1 isoform A-alpha' (human)

hNFATC1/iso:A-alpha'


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-8." [PRO:DNx, UniProtKB:O95644]


organism-modification



PR:000048588

nuclear factor of activated T-cells, cytoplasmic 1 phosphorylated 2 (human)

hNFATC1/Phos:2


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that has been post-translationally modified to include phosphoserine at positions 175, 176, 178, 179, 181, 233, 237, 241, 257, 278, 286 and 290 of the amino acid sequence represented by UniProtKB:O95644. UniProtKB:O95644, Ser-175/Ser-176/Ser-178/Ser-179/Ser-181/Ser-233/Ser-237/Ser-241/Ser-257/Ser-278/Ser-286/Ser-290, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025953]


organism-modification



PR:000048589

nuclear factor of activated T-cells, cytoplasmic 1 phosphorylated 3 (human)

hNFATC1/Phos:3


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-257 of the amino acid sequence represented by UniProtKB:O95644. UniProtKB:O95644, Ser-257, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025935, Reactome:R-HSA-2685618]


organism-modification



PR:000069331

nuclear factor of activated T-cells, cytoplasmic 1 cysteinylated 1 (human)

hNFATC1/Cyst:1


"A nuclear factor of activated T-cells, cytoplasmic 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-125 of the amino acid sequence represented by UniProtKB:O95644-1. Example: UniProtKB:O95644-1, Cys-125, MOD:00765." [IEDB_epitope:1050875, PRO:DNx]


sequence



PR:000003114

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1

NFATC1/iso:1


"A nuclear factor of activated T-cells, cytoplasmic 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95644-1 or a 1:1 ortholog thereof." [PMID:8202141, PRO:JAN]


organism-sequence



PR:O95644-1

nuclear factor of activated T-cells, cytoplasmic 1 isoform C-alpha (human)

hNFATC1/iso:C-alpha


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

Yes

organism-modification



PR:000036638

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 (human)

hNFATC1/iso:1/Phos:1


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 in human. UniProtKB:O95644-1, Ser-117/Ser-172, MOD:00046." [PMID:10866678, PRO:JAN]

Yes

modification



PR:000003117

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated form

NFATC1/iso:1/PhosRes+


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003116

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1

NFATC1/iso:1/Phos:1


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated form in which the phosphorylation occurs in the calcineurin targeting domain by the c-Jun NH2-terminal kinase (JNK). Example: UniProtKB:O95644-1, Ser-117/Ser-172, MOD:00046." [PMID:10866678, PRO:JAN]


organism-modification



PR:000036638

nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 (human)

hNFATC1/iso:1/Phos:1


"A nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 phosphorylated 1 in human. UniProtKB:O95644-1, Ser-117/Ser-172, MOD:00046." [PMID:10866678, PRO:JAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036638 hNFATC1/iso:1/Phos:1
UniProtKB:O95644-1, Ser-117/Ser-172, MOD:00046
enablesGO:0005515 protein binding with PR:O14980 chromosome region maintenance 1 protein homolog (human) PMID:10866678
located_inGO:0005737 cytoplasm PMID:10866678
PR:O95644-1 hNFATC1/iso:C-alpha enablesincreased GO:0005515 protein binding with PR:P45983 c-Jun N-terminal kinase 1 (human) PMID:10866678
increased GO:0005515 protein binding with PR:O14980 chromosome region maintenance 1 protein homolog (human) PMID:10866678
located_inGO:0005634 nucleus PMID:10866678