back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - map kinase p38
PR:000003106 - http://purl.obolibrary.org/obo/PR_000003106
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003106   
  PRO namemap kinase p38 
  Synonyms
PRO-Short-label: EXACT:fam:MAPKp38
  Definition"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (environmental stress, pro-inflammatory cytokines and lipopolysaccharide) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 13                                        
         Sequence4                                                  Organism-Sequence 18                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF500943
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000003106

map kinase p38

fam:MAPKp38


"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (environmental stress, pro-inflammatory cytokines and lipopolysaccharide) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA]


gene



PR:000003107

mitogen-activated protein kinase 14

MAPK14


"A map kinase p38 that is a translation product of the human MAPK14 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P47811

mitogen-activated protein kinase 14 (mouse)

mMAPK14


"A mitogen-activated protein kinase 14 that is encoded in the genome of mouse." [OMA:P47811, PRO:DNx]


organism-sequence



PR:P47811-1

mitogen-activated protein kinase 14 isoform 1 (mouse)

mMAPK14/iso:1


"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

Yes

organism-sequence



PR:P47811-2

mitogen-activated protein kinase 14 isoform m2 (mouse)

mMAPK14/iso:m2


"A mitogen-activated protein kinase 14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47811-2." [PRO:DNx, UniProtKB:P47811]


organism-sequence



PR:P47811-3

mitogen-activated protein kinase 14 isoform 3 (mouse)

mMAPK14/iso:3


"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P47811-4

mitogen-activated protein kinase 14 isoform m4 (mouse)

mMAPK14/iso:m4


"A mitogen-activated protein kinase 14 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47811-4." [PRO:DNx, UniProtKB:P47811]


organism-gene



PR:Q16539

mitogen-activated protein kinase 14 (human)

hMAPK14


"A mitogen-activated protein kinase 14 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16539]


organism-sequence



PR:Q16539-1

mitogen-activated protein kinase 14 isoform CSBP2 (human)

hMAPK14/iso:CSBP2


"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q16539-2

mitogen-activated protein kinase 14 isoform CSBP1 (human)

hMAPK14/iso:CSBP1


"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q16539-3

mitogen-activated protein kinase 14 isoform hMxi2 (human)

hMAPK14/iso:hMxi2


"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-3." [PRO:DNx, UniProtKB:Q16539]


organism-sequence



PR:Q16539-4

mitogen-activated protein kinase 14 isoform Exip (human)

hMAPK14/iso:Exip


"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-4." [PRO:DNx, UniProtKB:Q16539]


organism-sequence



PR:Q16539-5

mitogen-activated protein kinase 14 isoform h5 (human)

hMAPK14/iso:h5


"A mitogen-activated protein kinase 14 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-5." [PRO:DNx, UniProtKB:Q16539]


organism-modification



PR:000036637

mitogen-activated protein kinase 14 phosphorylated 1 (human)

hMAPK14/Phos:1


"A mitogen-activated protein kinase 14 phosphorylated 1 in human. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL]

Yes

organism-modification



PR:000048319

mitogen-activated protein kinase 14, initiator methionine removed form (human)

hMAPK14/InitMet-


"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed. UniProtKB:Q16539, 2-360." [PRO:DNx, Reactome:R-HSA-428933, Reactome:R-HSA-446223]


organism-modification



PR:000048320

mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)

hMAPK14/InitMet-/Phos:1


"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]


organism-modification



PR:000067949

mitogen-activated protein kinase 14 deaminated 1 (human)

hMAPK14/Deam:1


"A mitogen-activated protein kinase 14 (human) that has been deaminated on the residue at the position equivalent to Gln-325 of the amino acid sequence represented by UniProtKB:Q16539-1. Example: UniProtKB:Q16539-1, Gln-325, MOD:00685." [IEDB_epitope:1976216, PRO:DNx]


sequence



PR:000040708

mitogen-activated protein kinase 14 isoform 1

MAPK14/iso:1


"A mitogen-activated protein kinase 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P47811-1

mitogen-activated protein kinase 14 isoform 1 (mouse)

mMAPK14/iso:1


"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

Yes

organism-sequence



PR:Q16539-1

mitogen-activated protein kinase 14 isoform CSBP2 (human)

hMAPK14/iso:CSBP2


"A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of human." [PRO:DNx]


sequence



PR:000040709

mitogen-activated protein kinase 14 isoform 2

MAPK14/iso:2


"A mitogen-activated protein kinase 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16539-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P47811-3

mitogen-activated protein kinase 14 isoform 3 (mouse)

mMAPK14/iso:3


"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q16539-2

mitogen-activated protein kinase 14 isoform CSBP1 (human)

hMAPK14/iso:CSBP1


"A mitogen-activated protein kinase 14 isoform 2 that is encoded in the genome of human." [PRO:DNx]


modification



PR:000003108

mitogen-activated protein kinase 14 phosphorylated form

MAPK14/PhosRes+


"A mitogen-activated protein kinase 14 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003109

mitogen-activated protein kinase 14 phosphorylated 1

MAPK14/Phos:1


"A mitogen-activated protein kinase 14 that has been phosphorylated on residues at positions equivalent to Thr-180 and Tyr-182 of the amino acid sequence represented by UniProtKB:Q16539-1. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL, PRO:DAN]


organism-modification



PR:000036637

mitogen-activated protein kinase 14 phosphorylated 1 (human)

hMAPK14/Phos:1


"A mitogen-activated protein kinase 14 phosphorylated 1 in human. Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:15642743, PRO:CL]

Yes

organism-modification



PR:000048320

mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)

hMAPK14/InitMet-/Phos:1


"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]


modification



PR:000018784

mitogen-activated protein kinase 14, initiator methionine removed form

MAPK14/InitMet-


"A mitogen-activated protein kinase 14 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048319

mitogen-activated protein kinase 14, initiator methionine removed form (human)

hMAPK14/InitMet-


"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed. UniProtKB:Q16539, 2-360." [PRO:DNx, Reactome:R-HSA-428933, Reactome:R-HSA-446223]


organism-modification



PR:000048320

mitogen-activated protein kinase 14, initiator methionine removed phosphorylated 1 (human)

hMAPK14/InitMet-/Phos:1


"A mitogen-activated protein kinase 14 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q16539. UniProtKB:Q16539, 2-360, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PRO:DNx, Reactome:R-HSA-428935, Reactome:R-HSA-446227]


gene



PR:000010152

mitogen-activated protein kinase 11

MAPK11


"A map kinase p38 that is a translation product of the human MAPK11 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q15759

mitogen-activated protein kinase 11 (human)

hMAPK11


"A mitogen-activated protein kinase 11 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15759]


organism-sequence



PR:Q15759-1

mitogen-activated protein kinase 11 isoform 1 (human)

hMAPK11/iso:1


"A mitogen-activated protein kinase 11 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q15759-3

mitogen-activated protein kinase 11 isoform h2 (human)

hMAPK11/iso:h2


"A mitogen-activated protein kinase 11 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15759-3." [PRO:DNx, UniProtKB:Q15759]


organism-modification



PR:000048316

mitogen-activated protein kinase 11 phosphorylated 1 (human)

hMAPK11/Phos:1


"A mitogen-activated protein kinase 11 (human) that has been phosphorylated on the residue at the position equivalent to Thr-180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:Q15759. UniProtKB:Q15759, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:8846784, PRO:DNx, Reactome:R-HSA-171009, Reactome:R-HSA-198741]


organism-gene



PR:Q17446

mitogen-activated protein kinase pmk-1 (worm)

MAPK11 (worm)


"A mitogen-activated protein kinase 11 that is encoded in the genome of worm." [PRO:DNx]


organism-gene



PR:Q9WUI1

mitogen-activated protein kinase 11 (mouse)

mMAPK11


"A mitogen-activated protein kinase 11 that is encoded in the genome of mouse." [OMA:Q9WUI1, PRO:DNx]


organism-sequence



PR:Q9WUI1-1

mitogen-activated protein kinase 11 isoform 1 (mouse)

mMAPK11/iso:1


"A mitogen-activated protein kinase 11 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000040668

mitogen-activated protein kinase 11 isoform 1

MAPK11/iso:1


"A mitogen-activated protein kinase 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15759-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q15759-1

mitogen-activated protein kinase 11 isoform 1 (human)

hMAPK11/iso:1


"A mitogen-activated protein kinase 11 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9WUI1-1

mitogen-activated protein kinase 11 isoform 1 (mouse)

mMAPK11/iso:1


"A mitogen-activated protein kinase 11 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000010153

mitogen-activated protein kinase 12

MAPK12


"A map kinase p38 that is a translation product of the human MAPK12 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O08911

mitogen-activated protein kinase 12 (mouse)

mMAPK12


"A mitogen-activated protein kinase 12 that is encoded in the genome of mouse." [OMA:O08911, PRO:DNx]


organism-sequence



PR:O08911-1

mitogen-activated protein kinase 12 isoform 1 (mouse)

mMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P53778

mitogen-activated protein kinase 12 (human)

hMAPK12


"A mitogen-activated protein kinase 12 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P53778]


organism-sequence



PR:P53778-1

mitogen-activated protein kinase 12 isoform 1 (human)

hMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P53778-2

mitogen-activated protein kinase 12 isoform h2 (human)

hMAPK12/iso:h2


"A mitogen-activated protein kinase 12 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P53778-2." [PRO:DNx, UniProtKB:P53778]


organism-modification



PR:000048317

mitogen-activated protein kinase 12 phosphorylated 1 (human)

hMAPK12/Phos:1


"A mitogen-activated protein kinase 12 (human) that has been phosphorylated on the residue at the position equivalent to Thr-183, and phosphotyrosine at position 185 of the amino acid sequence represented by UniProtKB:P53778. UniProtKB:P53778, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PRO:DNx, Reactome:R-HSA-171021]


organism-gene



PR:Q63538

mitogen-activated protein kinase 12 (rat)

rMAPK12


"A mitogen-activated protein kinase 12 that is encoded in the genome of rat." [OMA:Q63538, PRO:DNx]


organism-sequence



PR:Q63538-1

mitogen-activated protein kinase 12 isoform 1 (rat)

rMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000039745

mitogen-activated protein kinase 12 isoform 1

MAPK12/iso:1


"A mitogen-activated protein kinase 12 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P53778-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O08911-1

mitogen-activated protein kinase 12 isoform 1 (mouse)

mMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P53778-1

mitogen-activated protein kinase 12 isoform 1 (human)

hMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q63538-1

mitogen-activated protein kinase 12 isoform 1 (rat)

rMAPK12/iso:1


"A mitogen-activated protein kinase 12 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


gene



PR:000010154

mitogen-activated protein kinase 13

MAPK13


"A map kinase p38 that is a translation product of the human MAPK13 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O15264

mitogen-activated protein kinase 13 (human)

hMAPK13


"A mitogen-activated protein kinase 13 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15264]


organism-sequence



PR:O15264-1

mitogen-activated protein kinase 13 isoform 1 (human)

hMAPK13/iso:1


"A mitogen-activated protein kinase 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15264-1." [PRO:DNx, UniProtKB:O15264]


organism-sequence



PR:O15264-2

mitogen-activated protein kinase 13 isoform h2 (human)

hMAPK13/iso:h2


"A mitogen-activated protein kinase 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15264-2." [PRO:DNx, UniProtKB:O15264]


organism-modification



PR:000048318

mitogen-activated protein kinase 13 phosphorylated 1 (human)

hMAPK13/Phos:1


"A mitogen-activated protein kinase 13 (human) that has been phosphorylated on the residue at the position equivalent to Thr-180, and phosphotyrosine at position 182 of the amino acid sequence represented by UniProtKB:O15264. UniProtKB:O15264, Thr-180, MOD:00047|Tyr-182, MOD:00048." [PMID:8846784, PRO:DNx, Reactome:R-HSA-171022]


organism-gene



PR:Q9WTY9

mitogen-activated protein kinase 13 (rat)

rMAPK13


"A mitogen-activated protein kinase 13 that is encoded in the genome of rat." [OMA:Q9WTY9, PRO:DNx]


organism-gene



PR:Q9Z1B7

mitogen-activated protein kinase 13 (mouse)

mMAPK13


"A mitogen-activated protein kinase 13 that is encoded in the genome of mouse." [OMA:Q9Z1B7, PRO:DNx]


organism-gene



PR:Q9DGE1

mitogen-activated protein kinase 14B (zebrafish)

z-mapk14b


"A map kinase p38 that is a translation product of the mapk14b gene in zebrafish." [PRO:DAN]


organism-gene



PR:Q9DGE2

mitogen-activated protein kinase 14A (zebrafish)

z-mapk14a


"A map kinase p38 that is a translation product of the mapk14a gene in zebrafish." [PRO:DAN]


Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036637 hMAPK14/Phos:1
Example: UniProtKB:Q16539-1, Thr-180, MOD:00047|Tyr-182, MOD:00048
acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:15642743
enablesGO:0004707 MAP kinase activity PMID:15642743
GO:0005515 protein binding PMID:15642743
PR:P47811-1 mMAPK14/iso:1 acts_upstream_of_or_withinGO:0014835 myoblast differentiation involved in skeletal muscle regeneration MGI_ref:4838005; PMID:20610565