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Protein Ontology report - cellular tumor antigen p53 isoform 1
PR:000003036 - http://purl.obolibrary.org/obo/PR_000003036
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003036   
  PRO namecellular tumor antigen p53 isoform 1 
  Synonyms
PRO-Short-label: EXACT:TP53/iso:1
  Definition"A cellular tumor antigen p53 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000003035 cellular tumor antigen p53
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification23                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000003036
cellular tumor antigen p53 isoform 1
TP53/iso:1
"A cellular tumor antigen p53 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P04637-1
cellular tumor antigen p53 isoform 1 (human)
hTP53/iso:1
"A cellular tumor antigen p53 isoform 1 that is encoded in the genome of human." [PMID:17671183, PMID:19252416, PRO:KER]
Yes
organism-modification


PR:000027764
cellular tumor antigen p53 isoform 1 phosphorylated 3 (human)
hTP53/iso:1/Phos:3
"A cellular tumor antigen p53 isoform 1 phosphorylated 3 in human. UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:DAN, PRO:PD]

organism-modification


PR:000027766
cellular tumor antigen p53 isoform 1 dimethylated 1 (human)
hTP53/iso:1/Me2:1
"A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]
Yes
organism-modification


PR:000027768
cellular tumor antigen p53 isoform 1 phosphorylated 4 (human)
hTP53/iso:1/Phos:4
"A cellular tumor antigen p53 isoform 1 phosphorylated 4 in human. UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD]

organism-modification


PR:000027770
cellular tumor antigen p53 isoform 1 phosphorylated 5 (human)
hTP53/iso:1/Phos:5
"A cellular tumor antigen p53 isoform 1 phosphorylated 5 in human. UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD]

organism-modification


PR:000027772
cellular tumor antigen p53 isoform 1 phosphorylated 6 (human)
hTP53/iso:1/Phos:6
"A cellular tumor antigen p53 isoform 1 phosphorylated 6 in human. UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD]

organism-modification


PR:000027774
cellular tumor antigen p53 isoform 1 acetylated 1 (human)
hTP53/iso:1/Ac:1
"A cellular tumor antigen p53 isoform 1 acetylated 1 in human. UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD]
Yes
organism-modification


PR:000027806
cellular tumor antigen p53 isoform 1 ubiquitinated 1 (human)
hTP53/iso:1/Ubiq:1
"A cellular tumor antigen p53 isoform 1 ubiquitinated 1 in human. UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD]

organism-modification


PR:000027808
cellular tumor antigen p53 isoform 1 methylated 3 (human)
hTP53/iso:1/Me:3
"A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD]
Yes
organism-modification


PR:000027810
cellular tumor antigen p53 isoform 1 methylated 4 (human)
hTP53/iso:1/Me:4
"A cellular tumor antigen p53 isoform 1 methylated 4 in human. UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD]
Yes
organism-modification


PR:000027812
cellular tumor antigen p53 isoform 1 acetylated 2 (human)
hTP53/iso:1/Ac:2
"A cellular tumor antigen p53 isoform 1 acetylated 2 in human. UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD]
Yes
organism-modification


PR:000027814
cellular tumor antigen p53 isoform 1 phosphorylated 12 (human)
hTP53/iso:1/Phos:12
"A cellular tumor antigen p53 isoform 1 phosphorylated 12 in human. UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD]
Yes
organism-modification


PR:000027827
cellular tumor antigen p53 isoform 1 dimethylated 2 (human)
hTP53/iso:1/Me2:2
"A cellular tumor antigen p53 isoform 1 dimethylated 2 in human. UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD]

organism-modification


PR:000027829
cellular tumor antigen p53 isoform 1 phosphorylated 7 (human)
hTP53/iso:1/Phos:7
"A cellular tumor antigen p53 isoform 1 phosphorylated 7 in human. UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD]

organism-modification


PR:000027831
cellular tumor antigen p53 isoform 1 phosphorylated 8 (human)
hTP53/iso:1/Phos:8
"A cellular tumor antigen p53 isoform 1 phosphorylated 8 in human. UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD]

organism-modification


PR:000027833
cellular tumor antigen p53 isoform 1 phosphorylated 9 (human)
hTP53/iso:1/Phos:9
"A cellular tumor antigen p53 isoform 1 phosphorylated 9 in human. UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD]
Yes
organism-modification


PR:000027835
cellular tumor antigen p53 isoform 1 O-glycosylated 1 (human)
hTP53/iso:1/OGlyco:1
"A cellular tumor antigen p53 isoform 1 O-glycosylated 1 in human. UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:PD]

organism-modification


PR:000027837
cellular tumor antigen p53 isoform 1 phosphorylated 10 (human)
hTP53/iso:1/Phos:10
"A cellular tumor antigen p53 isoform 1 phosphorylated 10 in human. UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD]

organism-modification


PR:000027839
cellular tumor antigen p53 isoform 1 phosphorylated 11 (human)
hTP53/iso:1/Phos:11
"A cellular tumor antigen p53 isoform 1 phosphorylated 11 in human. UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD]
Yes
organism-modification


PR:000027841
cellular tumor antigen p53 isoform 1 sumoylated 1 (human)
hTP53/iso:1/Sumo:1
"A cellular tumor antigen p53 isoform 1 sumoylated 1 in human. UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]

Yes
organism-modification


PR:000027846
cellular tumor antigen p53 isoform 1 unmodified form (human)
hTP53/iso:1/UnMod
"A cellular tumor antigen p53 isoform 1 unmodified form in human." [PMID:19339993, PRO:CNA]

Yes
organism-modification


PR:000035446
cellular tumor antigen p53 isoform 1 phosphorylated 1 (human)
hTP53/iso:1/Phos:1
"A cellular tumor antigen p53 isoform 1 phosphorylated 1 in human. UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:22099307, PRO:KER]
Yes
organism-modification


PR:000036624
cellular tumor antigen p53 isoform 1 phosphorylated 2 (human)
hTP53/iso:1/Phos:2
"A cellular tumor antigen p53 isoform 1 phosphorylated 2 in human. UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL]
Yes
modification


PR:000003037
cellular tumor antigen p53 isoform 1 unmodified form
TP53/iso:1/UnMod
"A cellular tumor antigen p53 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]

organism-modification


PR:000027846
cellular tumor antigen p53 isoform 1 unmodified form (human)
hTP53/iso:1/UnMod
"A cellular tumor antigen p53 isoform 1 unmodified form in human." [PMID:19339993, PRO:CNA]

Yes
modification


PR:000003038
cellular tumor antigen p53 isoform 1 phosphorylated form
TP53/iso:1/PhosRes+
"A cellular tumor antigen p53 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000003039
cellular tumor antigen p53 isoform 1 phosphorylated 1
TP53/iso:1/Phos:1
"A cellular tumor antigen p53 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:P04637-1. Example: UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:11602639, PRO:CL, PRO:DAN]

organism-modification


PR:000035446
cellular tumor antigen p53 isoform 1 phosphorylated 1 (human)
hTP53/iso:1/Phos:1
"A cellular tumor antigen p53 isoform 1 phosphorylated 1 in human. UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:22099307, PRO:KER]
Yes
modification


PR:000003040
cellular tumor antigen p53 isoform 1 phosphorylated 2
TP53/iso:1/Phos:2
"A cellular tumor antigen p53 isoform 1 phosphorylated form in which the phosphorylation occurs at residues equivalent to Ser-15/Ser-46 of the amino acid sequence represented by UniProtKB:P04637-1. Example: UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL, PRO:DAN]

organism-modification


PR:000036624
cellular tumor antigen p53 isoform 1 phosphorylated 2 (human)
hTP53/iso:1/Phos:2
"A cellular tumor antigen p53 isoform 1 phosphorylated 2 in human. UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL]
Yes
modification


PR:000027763
cellular tumor antigen p53 isoform 1 phosphorylated 3
TP53/iso:1/Phos:3
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at the Thr residue in the motif PTPAAPAPAPSWPLSS. This modification stabilizes p53 in response to stress. Example: UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:PD]

organism-modification


PR:000027764
cellular tumor antigen p53 isoform 1 phosphorylated 3 (human)
hTP53/iso:1/Phos:3
"A cellular tumor antigen p53 isoform 1 phosphorylated 3 in human. UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:DAN, PRO:PD]

modification


PR:000027767
cellular tumor antigen p53 isoform 1 phosphorylated 4
TP53/iso:1/Phos:4
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated on a Thr residue in the N-terminal activation domain 2 (AD2). This modification promotes MDM2-mediated p53 degradation and TAF1-mediated cell cycle progression. Example: UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD]

organism-modification


PR:000027768
cellular tumor antigen p53 isoform 1 phosphorylated 4 (human)
hTP53/iso:1/Phos:4
"A cellular tumor antigen p53 isoform 1 phosphorylated 4 in human. UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD]

modification


PR:000027769
cellular tumor antigen p53 isoform 1 phosphorylated 5
TP53/iso:1/Phos:5
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at Ser and Thr residues in the highly conserved PLSQETF motif in the N-terminal activation domain 1 (AD1). Phosphorylation at Thr residue is dependent on the prior phosphorylation of the Ser residue. Example: UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD]

organism-modification


PR:000027770
cellular tumor antigen p53 isoform 1 phosphorylated 5 (human)
hTP53/iso:1/Phos:5
"A cellular tumor antigen p53 isoform 1 phosphorylated 5 in human. UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD]

modification


PR:000027771
cellular tumor antigen p53 isoform 1 phosphorylated 6
TP53/iso:1/Phos:6
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at the Ser residue within the S10 beta strand located in the DNA binding domain (Pfam:PF00870). Example: UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD]

organism-modification


PR:000027772
cellular tumor antigen p53 isoform 1 phosphorylated 6 (human)
hTP53/iso:1/Phos:6
"A cellular tumor antigen p53 isoform 1 phosphorylated 6 in human. UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD]

modification


PR:000027813
cellular tumor antigen p53 isoform 1 phosphorylated 12
TP53/iso:1/Phos:12
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at two Ser residues, one located in the N-terminal transactivation domain and the other in the C-terminal region of p53. Example: UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD]

organism-modification


PR:000027814
cellular tumor antigen p53 isoform 1 phosphorylated 12 (human)
hTP53/iso:1/Phos:12
"A cellular tumor antigen p53 isoform 1 phosphorylated 12 in human. UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD]
Yes
modification


PR:000027828
cellular tumor antigen p53 isoform 1 phosphorylated 7
TP53/iso:1/Phos:7
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at multiple Ser residues, one within the N-terminal transactivation domain and other two in the C-terminal region of p53. Example: UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD]

organism-modification


PR:000027829
cellular tumor antigen p53 isoform 1 phosphorylated 7 (human)
hTP53/iso:1/Phos:7
"A cellular tumor antigen p53 isoform 1 phosphorylated 7 in human. UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD]

modification


PR:000027830
cellular tumor antigen p53 isoform 1 phosphorylated 8
TP53/iso:1/Phos:8
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at two Ser residues, one located in the DNA-binding domain and the other within the nuclear localization signal of the C-terminus of p53. Phosphorylation at Ser-215 hinders DNA binding and transactivation activity of p53. Example: UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD]

organism-modification


PR:000027831
cellular tumor antigen p53 isoform 1 phosphorylated 8 (human)
hTP53/iso:1/Phos:8
"A cellular tumor antigen p53 isoform 1 phosphorylated 8 in human. UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD]

modification


PR:000027832
cellular tumor antigen p53 isoform 1 phosphorylated 9
TP53/iso:1/Phos:9
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated on two Ser residues in the N-terminal transactivation domain in response to gamma-irradiation. Example: UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD]

organism-modification


PR:000027833
cellular tumor antigen p53 isoform 1 phosphorylated 9 (human)
hTP53/iso:1/Phos:9
"A cellular tumor antigen p53 isoform 1 phosphorylated 9 in human. UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD]
Yes
modification


PR:000027836
cellular tumor antigen p53 isoform 1 phosphorylated 10
TP53/iso:1/Phos:10
"A cellular tumor antigen p53 isoform 1 that is phosphorylated at multiple Ser residues located in the N-terminal region of p53 in response to DNA damage. The tetramerization domain of p53 is required for efficient phosphorylation at these 3 Ser residues. Example: UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD]

organism-modification


PR:000027837
cellular tumor antigen p53 isoform 1 phosphorylated 10 (human)
hTP53/iso:1/Phos:10
"A cellular tumor antigen p53 isoform 1 phosphorylated 10 in human. UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD]

modification


PR:000027838
cellular tumor antigen p53 isoform 1 phosphorylated 11
TP53/iso:1/Phos:11
"A cellular tumor antigen p53 isoform 1 that has been phosphorylated at multiple conserved sites within the DNA-binding domain. Example: UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD]

organism-modification


PR:000027839
cellular tumor antigen p53 isoform 1 phosphorylated 11 (human)
hTP53/iso:1/Phos:11
"A cellular tumor antigen p53 isoform 1 phosphorylated 11 in human. UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD]
Yes
modification


PR:000027765
cellular tumor antigen p53 isoform 1 dimethylated 1
TP53/iso:1/Me2:1
"A cellular tumor antigen p53 isoform 1 that has been dimethylated on a Lys residue present in the [KR]Kx(2)[LF]K[TR] sequence within the C-terminal regulatory region. This modification may promote p53 stability in response to DNA damage signals. Example: UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]

organism-modification


PR:000027766
cellular tumor antigen p53 isoform 1 dimethylated 1 (human)
hTP53/iso:1/Me2:1
"A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]
Yes
modification


PR:000027773
cellular tumor antigen p53 isoform 1 acetylated 1
TP53/iso:1/Ac:1
"A cellular tumor antigen p53 isoform 1 that has been acetylated on a Lys residue within the DNA binding domain (Pfam:PF00870) in response to genotoxic stress. Example: UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD]

organism-modification


PR:000027774
cellular tumor antigen p53 isoform 1 acetylated 1 (human)
hTP53/iso:1/Ac:1
"A cellular tumor antigen p53 isoform 1 acetylated 1 in human. UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD]
Yes
modification


PR:000027805
cellular tumor antigen p53 isoform 1 ubiquitinated 1
TP53/iso:1/Ubiq:1
"A cellular tumor antigen p53 isoform 1 that has been ubiquitinated at two highly conserved Lys residues in the C-terminal region of the DNA-binding domain. This modification promotes proteasomal degradation of p53. Example: UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD]

organism-modification


PR:000027806
cellular tumor antigen p53 isoform 1 ubiquitinated 1 (human)
hTP53/iso:1/Ubiq:1
"A cellular tumor antigen p53 isoform 1 ubiquitinated 1 in human. UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD]

modification


PR:000027807
cellular tumor antigen p53 isoform 1 methylated 3
TP53/iso:1/Me:3
"A cellular tumor antigen p53 isoform 1 that has been methylated at the second Lys residue of the [KR]-[STA]-K motif within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD]

organism-modification


PR:000027808
cellular tumor antigen p53 isoform 1 methylated 3 (human)
hTP53/iso:1/Me:3
"A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD]
Yes
modification


PR:000027809
cellular tumor antigen p53 isoform 1 methylated 4
TP53/iso:1/Me:4
"A cellular tumor antigen p53 isoform 1 that has been methylated at the first Lys residue of the K-[STA]-K within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD]

organism-modification


PR:000027810
cellular tumor antigen p53 isoform 1 methylated 4 (human)
hTP53/iso:1/Me:4
"A cellular tumor antigen p53 isoform 1 methylated 4 in human. UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD]
Yes
modification


PR:000027811
cellular tumor antigen p53 isoform 1 acetylated 2
TP53/iso:1/Ac:2
"A cellular tumor antigen p53 isoform 1 that has been acetylated on a Lys residue within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD]

organism-modification


PR:000027812
cellular tumor antigen p53 isoform 1 acetylated 2 (human)
hTP53/iso:1/Ac:2
"A cellular tumor antigen p53 isoform 1 acetylated 2 in human. UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD]
Yes
modification


PR:000027826
cellular tumor antigen p53 isoform 1 dimethylated 2
TP53/iso:1/Me2:2
"A cellular tumor antigen p53 isoform 1 that has been dimethylated on a Lys residue within the regulatory domain at the C terminus. Example: UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD]

organism-modification


PR:000027827
cellular tumor antigen p53 isoform 1 dimethylated 2 (human)
hTP53/iso:1/Me2:2
"A cellular tumor antigen p53 isoform 1 dimethylated 2 in human. UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD]

modification


PR:000027834
cellular tumor antigen p53 isoform 1 O-glycosylated 1
TP53/iso:1/OGlyco:1
"A cellular tumor antigen p53 isoform 1 that has been O-glycosylated on a Ser residue located in the DNA-binding domain. This modification stabilizes p53 by blocking ubiquitin-dependent proteolysis and also inhibits phosphorylation of p53 at Thr-155. Example: UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:DAN, PRO:PD]

organism-modification


PR:000027835
cellular tumor antigen p53 isoform 1 O-glycosylated 1 (human)
hTP53/iso:1/OGlyco:1
"A cellular tumor antigen p53 isoform 1 O-glycosylated 1 in human. UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:PD]

modification


PR:000027840
cellular tumor antigen p53 isoform 1 sumoylated 1
TP53/iso:1/Sumo:1
"A cellular tumor antigen p53 isoform 1 that has been sumoylated on a conserved Lys residue located within the regulatory C-terminal domain. While p53 sumoylation at Lys386 inhibits p300 mediated p53 acetylation (at Lys382 and Lys 373), p53 acetylation by p300 remains permissive for subsequent Lys386 sumoylation. Lys386 sumoylated p53 exists as a tetramer in solution. Example: UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]

organism-modification


PR:000027841
cellular tumor antigen p53 isoform 1 sumoylated 1 (human)
hTP53/iso:1/Sumo:1
"A cellular tumor antigen p53 isoform 1 sumoylated 1 in human. UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]

Yes
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TP53/iso:1 forms found in complexes   

TP53/iso:1 Component
 Complexes
PR:000027841 hTP53/iso:1/Sumo:1 PR:000027844 p53 complex sumoylated 1 (human)
PR:000027846 hTP53/iso:1/UnMod PR:000027844 p53 complex sumoylated 1 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027766 hTP53/iso:1/Me2:1
UniProtKB:P04637-1, Lys-382, MOD:00084		 enablesGO:0005515 protein binding with PR:Q12888 53BP1 (human) PMID:18840612
PR:000027774 hTP53/iso:1/Ac:1
UniProtKB:P04637-1, Lys-120, MOD:00064		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:17189187
PR:000027808 hTP53/iso:1/Me:3
UniProtKB:P04637-1, Lys-372, MOD:00663		 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:15525938
located_inGO:0005634 nucleus PMID:15525938
PR:000027810 hTP53/iso:1/Me:4
UniProtKB:P04637-1, Lys-370, MOD:00663		 acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:17108971
PR:000027812 hTP53/iso:1/Ac:2
UniProtKB:P04637-1, Lys-382, MOD:00064		 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:20228809
PR:000027814 hTP53/iso:1/Phos:12
UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046		 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:21317932
located_inGO:0005634 nucleus PMID:21317932
PR:000027833 hTP53/iso:1/Phos:9
UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046		 acts_upstream_of_or_withinGO:0010468 regulation of gene expression PMID:14712210
PR:000027839 hTP53/iso:1/Phos:11
UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047		 acts_upstream_of_or_withinGO:0010629 negative regulation of gene expression PMID:20959462
PR:000035446 hTP53/iso:1/Phos:1
UniProtKB:P04637-1, Ser-15, MOD:00046		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:11602639
located_inGO:0005634 nucleus PMID:11602639
PR:000036624 hTP53/iso:1/Phos:2
UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:15642743
enablesGO:0005515 protein binding with PR:000003109 MAPK p38 active form PMID:15642743
PR:P04637-1 hTP53/iso:1 enablesGO:0005515 protein binding with PR:O43683 BUB1 PMID:17671183
GO:0005515 protein binding with PR:O60566 BUB1B PMID:17671183