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Protein Ontology report - merlin
PR:000003020 - http://purl.obolibrary.org/obo/PR_000003020
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003020   
  PRO namemerlin 
  Synonyms
PRO-Short-label: EXACT:NF2
Gene-based: RELATED:Nf-2 | SCH
Other: EXACT:moesin-ezrin-radixin-like protein | neurofibromin-2 | schwannomerlin | schwannomin
  Definition"An erm protein that is a translation product of the human NF2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001030 erm protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 12                                        
         Modification5                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000003020

merlin

NF2


"An erm protein that is a translation product of the human NF2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35240

merlin (human)

hNF2


"A merlin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35240]


organism-sequence



PR:P35240-1

merlin isoform 1 (human)

hNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of human." [PMID:9430655, PRO:CNA]

Yes

organism-sequence



PR:P35240-10

merlin isoform h10 (human)

hNF2/iso:h10


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-10." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-2

merlin isoform 3 (human)

hNF2/iso:3


"A merlin isoform 3 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]


organism-sequence



PR:P35240-3

merlin isoform 2 (human)

hNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]

Yes

organism-sequence



PR:P35240-4

merlin isoform 4 (human)

hNF2/iso:4


"A merlin isoform 4 that is encoded in the genome of human." [PMID:10669747, PRO:CNA]

Yes

organism-sequence



PR:P35240-5

merlin isoform h5 (human)

hNF2/iso:h5


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-5." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-6

merlin isoform h6 (human)

hNF2/iso:h6


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-6." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-7

merlin isoform h7 (human)

hNF2/iso:h7


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-7." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-8

merlin isoform h8 (human)

hNF2/iso:h8


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-8." [PRO:DNx, UniProtKB:P35240]


organism-sequence



PR:P35240-9

merlin isoform h9 (human)

hNF2/iso:h9


"A merlin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-9." [PRO:DNx, UniProtKB:P35240]


organism-modification



PR:000045760

merlin phosphorylated 1 (human)

hNF2/Phos:1


"A merlin (human) that has been phosphorylated on the residue at the position equivalent to Ser-518 of the amino acid sequence represented by UniProtKB:P35240-1. Example: UniProtKB:P35240-1, Ser-518, MOD:00046." [iPTMnet:P35240, PMID:11719502, PMID:11782491, PMID:14981079, PMID:15378014, PMID:17566081]


organism-modification



PR:000080467

merlin methylated 1 (human)

hNF2/Me:1


"A merlin (human) that has been methylated on the residue at the position equivalent to Cys-51 of the amino acid sequence represented by UniProtKB:P35240-1. Example: UniProtKB:P35240-1, Cys-51, MOD:00660." [IEDB_epitope:1029135, PRO:DNx]


organism-gene



PR:P46662

merlin (mouse)

mNF2


"A merlin that is encoded in the genome of mouse." [OMA:P46662, PRO:DNx]


organism-sequence



PR:P46662-1

merlin isoform 1 (mouse)

mNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


organism-sequence



PR:P46662-2

merlin isoform 2 (mouse)

mNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


organism-gene



PR:Q24564

moesin/ezrin/radixin homolog 2 (fruit fly)

fly-NF2


"A merlin that is encoded in the genome of fruit fly." [OMA:Q24564, PRO:DNx]


sequence



PR:000003021

merlin isoform 1

NF2/iso:1


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-1 or a 1:1 ortholog thereof." [PMID:18071304]


organism-sequence



PR:P35240-1

merlin isoform 1 (human)

hNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of human." [PMID:9430655, PRO:CNA]

Yes

organism-sequence



PR:P46662-1

merlin isoform 1 (mouse)

mNF2/iso:1


"A merlin isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


modification



PR:000003024

merlin isoform 1 phosphorylated form

NF2/iso:1/PhosRes+


"A merlin isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003025

merlin isoform 1 phosphorylated 1

NF2/iso:1/Phos:1


"A merlin isoform 1 phosphorylated form that is phosphorylated in a C-terminal Ser residue within the PKA consensus site. Example: UniProtKB:P35240-1, Ser-518, MOD:00046." [PMID:18071304, PRO:AL]


modification



PR:000003026

merlin isoform 1 phosphorylated 2

NF2/iso:1/Phos:2


"A merlin isoform 1 phosphorylated form that is phosphorylated in a Ser residue (PKA consensus site) located within the N-terminal actin binding site, and it is also phosphorylated on a C-terminal Ser residue." [PMID:18071304, PRO:AL]


sequence



PR:000003022

merlin isoform 2

NF2/iso:2


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-3 or a 1:1 ortholog thereof." [PMID:18071304]


organism-sequence



PR:P35240-3

merlin isoform 2 (human)

hNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]

Yes

organism-sequence



PR:P46662-2

merlin isoform 2 (mouse)

mNF2/iso:2


"A merlin isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P46662]


modification



PR:000003028

merlin isoform 2 phosphorylated form

NF2/iso:2/PhosRes+


"A merlin isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003029

merlin isoform 2 phosphorylated 1

NF2/iso:2/Phos:1


"A merlin isoform 2 phosphorylated form that is phosphorylated in a Ser residue (PKA consensus site) located within the N-terminal actin binding site, and it is also phosphorylated on a C-terminal Ser residue." [PMID:18071304, PRO:AL]


sequence



PR:000026545

merlin isoform 3

NF2/iso:3


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-2 or a 1:1 ortholog thereof." [PMID:15467741, PRO:CNA]


organism-sequence



PR:P35240-2

merlin isoform 3 (human)

hNF2/iso:3


"A merlin isoform 3 that is encoded in the genome of human." [PMID:15467741, PRO:CNA]


sequence



PR:000026547

merlin isoform 4

NF2/iso:4


"A merlin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35240-4 or a 1:1 ortholog thereof." [PMID:10669747, PRO:CNA]


organism-sequence



PR:P35240-4

merlin isoform 4 (human)

hNF2/iso:4


"A merlin isoform 4 that is encoded in the genome of human." [PMID:10669747, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P35240-1 hNF2/iso:1 enablesGO:0005515 protein binding with PR:O14745 EBP50 (human) PMID:15467741
GO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
located_inGO:0005634 nucleus PMID:20178741
PR:P35240-3 hNF2/iso:2 enablesGO:0005515 protein binding with PR:Q9H204 EG1 PMID:15467741
PR:P35240-4 hNF2/iso:4 enablesGO:0005515 protein binding with PR:P0DPB3-1 PMID:10669747