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Protein Ontology report - tyrosine-protein kinase Lck
PR:000002998 - http://purl.obolibrary.org/obo/PR_000002998
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002998   
  PRO nametyrosine-protein kinase Lck 
  Synonyms
PRO-Short-label: EXACT:LCK
Gene-based: RELATED:Lsk-t
Other: EXACT:leukocyte C-terminal Src kinase | LSK | lymphocyte cell-specific protein-tyrosine kinase | p56-LCK | proto-oncogene Lck | proto-oncogene tyrosine-protein kinase lck | T cell-specific protein-tyrosine kinase
  Definition"A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human LCK gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000002997 proto-oncogene SRC-like tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2053
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002998

tyrosine-protein kinase Lck

LCK


"A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human LCK gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P06239

tyrosine-protein kinase Lck (human)

hLCK


"A tyrosine-protein kinase Lck that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P06239-1

tyrosine-protein kinase Lck isoform Long (human)

hLCK/iso:Long


"A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036619

tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)

hLCK/iso:1/Phos:1


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000036622

tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)

hLCK/iso:1/Phos:2


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-sequence



PR:P06239-2

tyrosine-protein kinase Lck isoform Short (human)

hLCK/iso:Short


"A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-2." [PRO:DNx, UniProtKB:P06239]


organism-sequence



PR:P06239-3

tyrosine-protein kinase Lck isoform h3 (human)

hLCK/iso:h3


"A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-3." [PRO:DNx, UniProtKB:P06239]


organism-modification



PR:000048171

tyrosine-protein kinase Lck phosphorylated 2 (human)

hLCK/Phos:2


"A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-394, MOD:00048." [PRO:DNx, Reactome:R-HSA-202308, Reactome:R-HSA-8857940]


organism-modification



PR:000048172

tyrosine-protein kinase Lck phosphorylated 3 (human)

hLCK/Phos:3


"A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-505 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-505, MOD:00048." [PRO:DNx, Reactome:R-HSA-202159]


organism-gene



PR:P06240

proto-oncogene tyrosine-protein kinase LCK (mouse)

mLCK


"A tyrosine-protein kinase Lck that is encoded in the genome of mouse." [OMA:P06240, PRO:CNA]


organism-sequence



PR:P06240-1

proto-oncogene tyrosine-protein kinase LCK isoform 1 (mouse)

mLCK/iso:1


"A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000045642

proto-oncogene tyrosine-protein kinase LCK phosphorylated 1 (mouse)

mLCK/Phos:1


"A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated at Tyr-505. UniProtKB:P06240, Tyr-505, MOD:00048." [iPTMnet:P06240, PMID:8413300]


organism-modification



PR:000049824

proto-oncogene tyrosine-protein kinase LCK phosphorylated 2 (mouse)

mLCK/Phos:2


"A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-35 of the amino acid sequence represented by UniProtKB:P06240. UniProtKB:P06240, Ser-35, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049825

proto-oncogene tyrosine-protein kinase LCK phosphorylated 3 (mouse)

mLCK/Phos:3


"A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated on the residue at the position equivalent to Tyr-192 of the amino acid sequence represented by UniProtKB:P06240. UniProtKB:P06240, Tyr-192, MOD:00048." [PMID:21183079, PRO:HJD]


organism-gene



PR:Q01621

proto-oncogene tyrosine-protein kinase LCK (rat)

rLCK


"A tyrosine-protein kinase Lck that is encoded in the genome of rat." [OMA:Q01621, PRO:DNx]


sequence



PR:000002999

tyrosine-protein kinase Lck isoform 1

LCK/iso:1


"A tyrosine-protein kinase Lck that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P06239-1

tyrosine-protein kinase Lck isoform Long (human)

hLCK/iso:Long


"A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036619

tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)

hLCK/iso:1/Phos:1


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000036622

tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)

hLCK/iso:1/Phos:2


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-sequence



PR:P06240-1

proto-oncogene tyrosine-protein kinase LCK isoform 1 (mouse)

mLCK/iso:1


"A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000003000

tyrosine-protein kinase Lck isoform 1 phosphorylated form

LCK/iso:1/PhosRes+


"A tyrosine-protein kinase Lck isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003001

tyrosine-protein kinase Lck isoform 1 phosphorylated 1

LCK/iso:1/Phos:1


"A tyrosine-protein kinase Lck isoform 1 phosphorylated form in which the phosphorylation occurs at the autoinhibitory Tyr residue (Tyr-505 in human lck), and in the activation Tyr residue (Tyr-394 in human lck). This form is predominant in the presence of HIV gp120 protein. Example: UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL, PRO:DAN]


organism-modification



PR:000036619

tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)

hLCK/iso:1/Phos:1


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]

Yes

modification



PR:000003034

tyrosine-protein kinase Lck isoform 1 phosphorylated 2

LCK/iso:1/Phos:2


"A tyrosine-protein kinase Lck isoform 1 phosphorylated form in which the phosphorylation occurs at the activation Tyr residue (Tyr-394 in human lck). Example: UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL, PRO:DAN]


organism-modification



PR:000036622

tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)

hLCK/iso:1/Phos:2


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL]

Yes

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LCK forms found in complexes   

LCK Component
Complexes
PR:P06239 hLCK PR:000028449 CD4:Lck complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036619 hLCK/iso:1/Phos:1
UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048
enablesdecreased GO:0016301 kinase activity relative to PR:000036622 hLCK/iso:1/Phos:2 PMID:9043947
PR:000036622 hLCK/iso:1/Phos:2
UniProtKB:P06239-1, Tyr-394, MOD:00048
enablesGO:0016301 kinase activity PMID:9043947
GO:0044877 protein-containing complex binding PMID:9043947