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Protein Ontology report - catenin beta-1 isoform 1
PR:000002319 - http://purl.obolibrary.org/obo/PR_000002319
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002319   
  PRO namecatenin beta-1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:CTNNB1/iso:1
  Definition"A catenin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35222-1 or a 1:1 ortholog thereof." [PRO:JAN] 
  PRO Categorysequence 
  ParentPR:000002198 catenin beta-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification23                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
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Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000002319
catenin beta-1 isoform 1
CTNNB1/iso:1
"A catenin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35222-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P35222-1
catenin beta-1 isoform 1 (human)
hCTNNB1/iso:1
"A catenin beta-1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000028553
catenin beta-1 isoform 1 acetylated 1 (human)
hCTNNB1/iso:1/Ac:1
"A catenin beta-1 isoform 1 acetylated 1 in human. UniProtKB:P35222-1, Lys-345, MOD:00064." [KAT:P35222, PMID:15060161, PRO:DAN, PRO:PD]

organism-modification


PR:000028794
catenin beta-1 isoform 1 acetylated 2 (human)
hCTNNB1/iso:1/Ac:2
"A catenin beta-1 isoform 1 acetylated 2 in human. UniProtKB:P35222-1, Lys-19/Lys-49, MOD:00064." [PMID:18987336, PRO:PD]

organism-modification


PR:000030192
catenin beta-1 isoform 1 phosphorylated 1 (human)
hCTNNB1/iso:1/Phos:1
"A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046." [PMID:22369945, PRO:IC]
Yes
organism-modification


PR:000035770
catenin beta-1 isoform 1 phosphorylated 2 (human)
hCTNNB1/iso:1/Phos:2
"A catenin beta-1 isoform 1 phosphorylated 2 in human. Tyr-64 is the major phosphorylation site for PTK6. UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)." [PMID:20026641, PRO:IC]
Yes
organism-modification


PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human)
hCTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 phosphorylated 3 in human. Phosphorylation at Ser-45 is needed for the other sites to be phosphorylated. UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:12000790, PMID:16199882, PRO:IC]
Yes
organism-modification


PR:000035774
catenin beta-1 isoform 1 phosphorylated 4 (human)
hCTNNB1/iso:1/Phos:4
"A catenin beta-1 isoform 1 phosphorylated 4 in human. UniProtKB:P35222-1, Ser-45, MOD:00046." [PMID:11955436, PMID:16199882, PRO:IC]
Yes
organism-modification


PR:000036862
catenin beta-1 isoform 1 phosphorylated 5 (human)
hCTNNB1/iso:1/Phos:5
"A catenin beta-1 isoform 1 phosphorylated 5 in human. UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046." [PMID:16476742, PRO:IC]
Yes
organism-modification


PR:000036872
catenin beta-1 isoform 1 unphosphorylated 1 (human)
hCTNNB1/iso:1/UnPhos:1
"A catenin beta-1 isoform 1 unphosphorylated 1 in human. UniProtKB:P35222-1, Ser-552/Ser-675, PR:000026291." [PMID:16476742, PRO:KER]

organism-modification


PR:000037181
catenin beta-1 isoform 1 phosphorylated 6 (human)
hCTNNB1/iso:1/Phos:6
"A catenin beta-1 isoform 1 phosphorylated 6 in human. UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:19667122, PRO:IC]
Yes
organism-modification


PR:000037185
catenin beta-1 isoform 1 unphosphorylated 2 (human)
hCTNNB1/iso:1/UnPhos:2
"A catenin beta-1 isoform 1 unphosphorylated 2 in human. UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291." [PRO:CNA]
Yes
organism-modification


PR:000037190
catenin beta-1 isoform 1 phosphorylated 7 (human)
hCTNNB1/iso:1/Phos:7
"A catenin beta-1 isoform 1 phosphorylated 7 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:14500351, PRO:IC]
Yes
organism-modification


PR:000037192
catenin beta-1 isoform 1 phosphorylated 8 (human)
hCTNNB1/iso:1/Phos:8
"A catenin beta-1 isoform 1 phosphorylated 8 in human. UniProtKB:P35222-1, Tyr-333, MOD:00048." [PMID:22056988, PRO:IC]
Yes
organism-modification


PR:000037194
catenin beta-1 isoform 1 phosphorylated 9 (human)
hCTNNB1/iso:1/Phos:9
"A catenin beta-1 isoform 1 phosphorylated 9 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048." [PMID:10593980, PRO:IC]
Yes
organism-modification


PR:000037196
catenin beta-1 isoform 1 unphosphorylated 3 (human)
hCTNNB1/iso:1/UnPhos:3
"A catenin beta-1 isoform 1 unphosphorylated 3 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, PR:000026291." [PMID:10593980, PRO:DAN, PRO:IC]

organism-modification


PR:000037229
catenin beta-1 isoform 1 phosphorylated 10 (human)
hCTNNB1/iso:1/Phos:10
"A catenin beta-1 isoform 1 phosphorylated 10 in human. UniProtKB:P35222-1, Ser-191/Ser-246, MOD:00046." [PMID:17009320, PRO:IC]

organism-modification


PR:000037515
catenin beta-1 isoform 1 phosphorylated 11 (human)
hCTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 phosphorylated 11 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]
Yes
organism-modification


PR:000037772
catenin beta-1 isoform 1 unphosphorylated 4 (human)
hCTNNB1/iso:1/UnPhos:4
"A catenin beta-1 isoform 1 unphosphorylated 4 in human. UniProtKB:P35222-1, Ser-33/Ser-37, PR:000026291." [PMID:20307497, PRO:IC, PRO:KER]

organism-modification


PR:000037811
catenin beta-1 isoform 1 unphosphorylated 5 (human)
hCTNNB1/iso:1/UnPhos:5
"A catenin beta-1 isoform 1 unphosphorylated 5 in human. UniProtKB:P35222-1, Ser-33/Ser-37/Thr-41, PR:000026291." [PMID:19667122, PMID:20419129, PMID:21152425, PMID:23617586, PRO:KER]

organism-modification


PR:000037813
catenin beta-1 isoform 1 unphosphorylated 6 (human)
hCTNNB1/iso:1/UnPhos:6
"A catenin beta-1 isoform 1 unphosphorylated 6 in human. UniProtKB:P35222-1, Ser-45, PR:000026291." [PMID:20419129, PRO:KER]

organism-modification


PR:000044474
catenin beta-1 isoform 1 phosphorylated 12 (human)
hCTNNB1/iso:1/Phos:12
"A catenin beta-1 isoform 1 phosphorylated 12 in human. UniProtKB:P35222-1, Thr-393, MOD:00047." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
organism-modification


PR:000044476
catenin beta-1 isoform 1 unphosphorylated 7 (human)
hCTNNB1/iso:1/UnPhos:7
"A catenin beta-1 isoform 1 unphosphorylated 7 in human. UniProtKB:P35222-1, Thr-393, PR:000026291." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
organism-modification


PR:000044478
catenin beta-1 isoform 1 phosphorylated 13 (human)
hCTNNB1/iso:1/Phos:13
"A catenin beta-1 isoform 1 phosphorylated 13 in human. UniProtKB:P35222-1, Tyr-654, MOD:00048." [PMID:23640056, PRO:KER]
Yes
organism-modification


PR:000044510
catenin beta-1 isoform 1 phosphorylated 14 (human)
hCTNNB1/iso:1/Phos:14
"A catenin beta-1 isoform 1 (human) that has been phosphorylated on a Ser residue within the 14-3-3 recognition motif. UniProtKB:P35222-1, Ser-552, MOD:00046." [PMID:17287208, PRO:CNA]
Yes
organism-sequence


PR:Q02248-1
catenin beta-1 isoform 1 (mouse)
mCTNNB1/iso:1
"A catenin beta-1 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000037516
catenin beta-1 isoform 1 phosphorylated 11 (mouse)
mCTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 phosphorylated 11 in mouse. UniProtKB:Q02248-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]

modification


PR:000002862
catenin beta-1 isoform 1 unmodified form
CTNNB1/iso:1/UnMod
"A catenin beta-1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]

modification


PR:000028552
catenin beta-1 isoform 1 acetylated 1
CTNNB1/iso:1/Ac:1
"A catenin beta-1 isoform 1 that has been acetylated on a Lys residue located in arm repeat 6. Example: UniProtKB:P35222-1, Lys-345, MOD:00064." [KAT:P35222, PMID:15060161, PRO:PD]

organism-modification


PR:000028553
catenin beta-1 isoform 1 acetylated 1 (human)
hCTNNB1/iso:1/Ac:1
"A catenin beta-1 isoform 1 acetylated 1 in human. UniProtKB:P35222-1, Lys-345, MOD:00064." [KAT:P35222, PMID:15060161, PRO:DAN, PRO:PD]

modification


PR:000028793
catenin beta-1 isoform 1 acetylated 2
CTNNB1/iso:1/Ac:2
"A catenin beta-1 isoform 1 that has been acetylated on Lys residues located towards the N terminus. Example: UniProtKB:P35222-1, Lys-19/Lys-49, MOD:00064." [PMID:18987336, PRO:PD]

organism-modification


PR:000028794
catenin beta-1 isoform 1 acetylated 2 (human)
hCTNNB1/iso:1/Ac:2
"A catenin beta-1 isoform 1 acetylated 2 in human. UniProtKB:P35222-1, Lys-19/Lys-49, MOD:00064." [PMID:18987336, PRO:PD]

modification


PR:000030191
catenin beta-1 isoform 1 phosphorylated 1
CTNNB1/iso:1/Phos:1
"A catenin beta-1 isoform 1 that has been phosphorylated in two of the PAK1 consensus site (RXS/T). Example: UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046." [PMID:22369945, PRO:IC]

organism-modification


PR:000030192
catenin beta-1 isoform 1 phosphorylated 1 (human)
hCTNNB1/iso:1/Phos:1
"A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046." [PMID:22369945, PRO:IC]
Yes
modification


PR:000035769
catenin beta-1 isoform 1 phosphorylated 2
CTNNB1/iso:1/Phos:2
"A catenin beta-1 isoform 1 that has been phosphorylated on Tyr residues located at the N-terminal region, and the first and fifth ARM repeats. Example: UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)." [PMID:20026641, PRO:IC]

organism-modification


PR:000035770
catenin beta-1 isoform 1 phosphorylated 2 (human)
hCTNNB1/iso:1/Phos:2
"A catenin beta-1 isoform 1 phosphorylated 2 in human. Tyr-64 is the major phosphorylation site for PTK6. UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)." [PMID:20026641, PRO:IC]
Yes
modification


PR:000035771
catenin beta-1 isoform 1 phosphorylated 3
CTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 that has been phosphorylated on Ser and Thr residues within the GSK3B recognition motif DSGxxS and the third Thr residue and second Ser residue within the adjacent sequence GATTTAPSLS. Apparently phosphorylation is sequential and occurs from C- to N terminus of the sequence. Phosphorylation of these sites target beta catenin-1 for degradation. Example: UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:16199882, PRO:IC]

organism-modification


PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human)
hCTNNB1/iso:1/Phos:3
"A catenin beta-1 isoform 1 phosphorylated 3 in human. Phosphorylation at Ser-45 is needed for the other sites to be phosphorylated. UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:12000790, PMID:16199882, PRO:IC]
Yes
modification


PR:000035773
catenin beta-1 isoform 1 phosphorylated 4
CTNNB1/iso:1/Phos:4
"A catenin beta-1 isoform 1 that has been phosphorylated on the last Ser residue in the motif LDSGIHSGATTTAPSLS. Example: UniProtKB:P35222-1, Ser-45, MOD:00046." [PMID:11955436, PMID:16199882, PRO:IC]

organism-modification


PR:000035774
catenin beta-1 isoform 1 phosphorylated 4 (human)
hCTNNB1/iso:1/Phos:4
"A catenin beta-1 isoform 1 phosphorylated 4 in human. UniProtKB:P35222-1, Ser-45, MOD:00046." [PMID:11955436, PMID:16199882, PRO:IC]
Yes
modification


PR:000036861
catenin beta-1 isoform 1 phosphorylated 5
CTNNB1/iso:1/Phos:5
"A catenin beta-1 isoform 1 that has been phosphorylated on two Ser residues in the cAMP-dependent protein kinase phosphorylation consensus sites, [RK](2)-x-[ST] located towards the C-terminal region. Example: UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046." [PMID:16476742, PRO:IC]

organism-modification


PR:000036862
catenin beta-1 isoform 1 phosphorylated 5 (human)
hCTNNB1/iso:1/Phos:5
"A catenin beta-1 isoform 1 phosphorylated 5 in human. UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046." [PMID:16476742, PRO:IC]
Yes
modification


PR:000036871
catenin beta-1 isoform 1 unphosphorylated 1
CTNNB1/iso:1/UnPhos:1
"A catenin beta-1 isoform 1 that lacks phosphorylation at positions equivalent to Ser-552 and Ser-675 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-552/Ser-675, PR:000026291." [PMID:16476742, PRO:DAN, PRO:KER]

organism-modification


PR:000036872
catenin beta-1 isoform 1 unphosphorylated 1 (human)
hCTNNB1/iso:1/UnPhos:1
"A catenin beta-1 isoform 1 unphosphorylated 1 in human. UniProtKB:P35222-1, Ser-552/Ser-675, PR:000026291." [PMID:16476742, PRO:KER]

modification


PR:000037180
catenin beta-1 isoform 1 phosphorylated 6
CTNNB1/iso:1/Phos:6
"A catenin beta-1 isoform 1 that has been phosphorylated on a Ser and a Thr residues located in the N-terminal loop region. The phosphorylation occurs in the context of the E-cadherin/beta-catenin complex. Example: UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:19667122, PRO:IC]

organism-modification


PR:000037181
catenin beta-1 isoform 1 phosphorylated 6 (human)
hCTNNB1/iso:1/Phos:6
"A catenin beta-1 isoform 1 phosphorylated 6 in human. UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:19667122, PRO:IC]
Yes
modification


PR:000037184
catenin beta-1 isoform 1 unphosphorylated 2
CTNNB1/iso:1/UnPhos:2
"A catenin beta-1 isoform 1 that lacks phosphorylation at positions equivalent to Ser-37 and Thr-41 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291." [PRO:CNA]

organism-modification


PR:000037185
catenin beta-1 isoform 1 unphosphorylated 2 (human)
hCTNNB1/iso:1/UnPhos:2
"A catenin beta-1 isoform 1 unphosphorylated 2 in human. UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291." [PRO:CNA]
Yes
modification


PR:000037189
catenin beta-1 isoform 1 phosphorylated 7
CTNNB1/iso:1/Phos:7
"A catenin beta-1 isoform 1 that has been phosphorylated on a Ser and a Thr residues located in the N-terminal region, but not on the Ser-45. Example: UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:14500351, PRO:IC]

organism-modification


PR:000037190
catenin beta-1 isoform 1 phosphorylated 7 (human)
hCTNNB1/iso:1/Phos:7
"A catenin beta-1 isoform 1 phosphorylated 7 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:14500351, PRO:IC]
Yes
modification


PR:000037191
catenin beta-1 isoform 1 phosphorylated 8
CTNNB1/iso:1/Phos:8
"A catenin beta-1 isoform 1 that has been phosphorylated on the Tyr residue in the motif YELKLL located within the fifth ARM repeat. Example: UniProtKB:P35222-1, Tyr-333, MOD:00048." [PMID:22056988, PRO:IC]

organism-modification


PR:000037192
catenin beta-1 isoform 1 phosphorylated 8 (human)
hCTNNB1/iso:1/Phos:8
"A catenin beta-1 isoform 1 phosphorylated 8 in human. UniProtKB:P35222-1, Tyr-333, MOD:00048." [PMID:22056988, PRO:IC]
Yes
modification


PR:000037193
catenin beta-1 isoform 1 phosphorylated 9
CTNNB1/iso:1/Phos:9
"A catenin beta-1 isoform 1 that has been phosphorylated on two Tyr residues located in the N-terminal domain and in the last armadillo repeat of beta-catenin, respectively. Example: UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048." [PMID:10593980, PRO:IC]

organism-modification


PR:000037194
catenin beta-1 isoform 1 phosphorylated 9 (human)
hCTNNB1/iso:1/Phos:9
"A catenin beta-1 isoform 1 phosphorylated 9 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048." [PMID:10593980, PRO:IC]
Yes
modification


PR:000037195
catenin beta-1 isoform 1 unphosphorylated 3
CTNNB1/iso:1/UnPhos:3
"A catenin beta-1 isoform 1 that lacks phosphorylation at positions equivalent to Tyr-86 and Tyr-654 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Tyr-86/Tyr-654, PR:000026291." [PMID:10593980, PRO:DAN, PRO:IC]

organism-modification


PR:000037196
catenin beta-1 isoform 1 unphosphorylated 3 (human)
hCTNNB1/iso:1/UnPhos:3
"A catenin beta-1 isoform 1 unphosphorylated 3 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, PR:000026291." [PMID:10593980, PRO:DAN, PRO:IC]

modification


PR:000037228
catenin beta-1 isoform 1 phosphorylated 10
CTNNB1/iso:1/Phos:10
"A catenin beta-1 isoform 1 that has been phosphorylated on two Ser residues located in the first and third armadillo (ARM) repeats. Example: UniProtKB:P35222-1, Ser-191/Ser-246, MOD:00046." [PMID:17009320, PRO:IC]

organism-modification


PR:000037229
catenin beta-1 isoform 1 phosphorylated 10 (human)
hCTNNB1/iso:1/Phos:10
"A catenin beta-1 isoform 1 phosphorylated 10 in human. UniProtKB:P35222-1, Ser-191/Ser-246, MOD:00046." [PMID:17009320, PRO:IC]

modification


PR:000037514
catenin beta-1 isoform 1 phosphorylated 11
CTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 that has been phosphorylated on two N-terminal region Ser residues equivalent to Ser-33 and Ser-37 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]

organism-modification


PR:000037515
catenin beta-1 isoform 1 phosphorylated 11 (human)
hCTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 phosphorylated 11 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]
Yes
organism-modification


PR:000037516
catenin beta-1 isoform 1 phosphorylated 11 (mouse)
mCTNNB1/iso:1/Phos:11
"A catenin beta-1 isoform 1 phosphorylated 11 in mouse. UniProtKB:Q02248-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]

modification


PR:000037771
catenin beta-1 isoform 1 unphosphorylated 4
CTNNB1/iso:1/UnPhos:4
"A catenin beta-1 isoform 1 that lacks phosphorylation on two N-terminal region Ser residues equivalent to Ser-33 and Ser-37 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-33/Ser-37, PR:000026291." [PMID:20307497, PRO:IC, PRO:KER]

organism-modification


PR:000037772
catenin beta-1 isoform 1 unphosphorylated 4 (human)
hCTNNB1/iso:1/UnPhos:4
"A catenin beta-1 isoform 1 unphosphorylated 4 in human. UniProtKB:P35222-1, Ser-33/Ser-37, PR:000026291." [PMID:20307497, PRO:IC, PRO:KER]

modification


PR:000037810
catenin beta-1 isoform 1 unphosphorylated 5
CTNNB1/iso:1/UnPhos:5
"A catenin beta-1 isoform 1 that lacks phosphorylation at positions equivalent to Ser-33, Ser-37, and Thr-41 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-33/Ser-37/Thr-41, PR:000026291." [PMID:19667122, PMID:20419129, PMID:21152425, PMID:23617586, PRO:KER]

organism-modification


PR:000037811
catenin beta-1 isoform 1 unphosphorylated 5 (human)
hCTNNB1/iso:1/UnPhos:5
"A catenin beta-1 isoform 1 unphosphorylated 5 in human. UniProtKB:P35222-1, Ser-33/Ser-37/Thr-41, PR:000026291." [PMID:19667122, PMID:20419129, PMID:21152425, PMID:23617586, PRO:KER]

modification


PR:000037812
catenin beta-1 isoform 1 unphosphorylated 6
CTNNB1/iso:1/UnPhos:6
"A catenin beta-1 isoform 1 that lacks phosphorylation on the residue at the position equivalent to Ser-45 of the amino acid sequence represented by UniProtKB:P35222-1. Example: UniProtKB:P35222-1, Ser-45, PR:000026291." [PMID:20419129, PRO:KER]

organism-modification


PR:000037813
catenin beta-1 isoform 1 unphosphorylated 6 (human)
hCTNNB1/iso:1/UnPhos:6
"A catenin beta-1 isoform 1 unphosphorylated 6 in human. UniProtKB:P35222-1, Ser-45, PR:000026291." [PMID:20419129, PRO:KER]

modification


PR:000044473
catenin beta-1 isoform 1 phosphorylated 12
CTNNB1/iso:1/Phos:12
"A catenin beta-1 isoform 1 that has been phosphorylated on a Thr residue located in the linking region between the sixth and seventh armadillo repeat of beta-catenin. Example: UniProtKB:P35222-1, Thr-393, MOD:00047." [PMID:12700239, PMID:19565571, PRO:KER]

organism-modification


PR:000044474
catenin beta-1 isoform 1 phosphorylated 12 (human)
hCTNNB1/iso:1/Phos:12
"A catenin beta-1 isoform 1 phosphorylated 12 in human. UniProtKB:P35222-1, Thr-393, MOD:00047." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
modification


PR:000044475
catenin beta-1 isoform 1 unphosphorylated 7
CTNNB1/iso:1/UnPhos:7
"A catenin beta-1 isoform 1 that lacks phosphorylation on a Thr residue located in the linking region between the sixth and seventh armadillo repeat of beta-catenin. Example: UniProtKB:P35222-1, Thr-393, PR:000026291." [PMID:12700239, PMID:19565571, PRO:KER]

organism-modification


PR:000044476
catenin beta-1 isoform 1 unphosphorylated 7 (human)
hCTNNB1/iso:1/UnPhos:7
"A catenin beta-1 isoform 1 unphosphorylated 7 in human. UniProtKB:P35222-1, Thr-393, PR:000026291." [PMID:12700239, PMID:19565571, PRO:KER]
Yes
modification


PR:000044477
catenin beta-1 isoform 1 phosphorylated 13
CTNNB1/iso:1/Phos:13
"A catenin beta-1 isoform 1 that has been phosphorylated on a Tyr residue located in the last armadillo repeat of beta-catenin. Example: UniProtKB:P35222-1, Tyr-654, MOD:00048." [PMID:23640056, PRO:KER]

organism-modification


PR:000044478
catenin beta-1 isoform 1 phosphorylated 13 (human)
hCTNNB1/iso:1/Phos:13
"A catenin beta-1 isoform 1 phosphorylated 13 in human. UniProtKB:P35222-1, Tyr-654, MOD:00048." [PMID:23640056, PRO:KER]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000030192 hCTNNB1/iso:1/Phos:1
UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:22369945
enablesincreased GO:0003713 transcription coactivator activity relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
PR:000035770 hCTNNB1/iso:1/Phos:2
UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)		 located_inGO:0005634 nucleus PMID:20026641
PR:000035772 hCTNNB1/iso:1/Phos:3
UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047		 enablesNOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:10074433
NOT GO:0005515 protein binding with PR:Q9UKB1 BTRCP2 PMID:10074433
PR:000035774 hCTNNB1/iso:1/Phos:4
UniProtKB:P35222-1, Ser-45, MOD:00046		 enablesincreased GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:12051714; PMID:20419129; PMID:23606879
increased GO:0005515 protein binding with PR:P49841 GSK-3 beta (human) PMID:12051714; PMID:20419129; PMID:23606879
located_inGO:0005634 nucleus PMID:20419129
PR:000036862 hCTNNB1/iso:1/Phos:5
UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046		 enablesincreased GO:0003713 transcription coactivator activity relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
increased GO:0005515 protein binding relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
PR:000037181 hCTNNB1/iso:1/Phos:6
UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047		 located_indecreased GO:0005912 adherens junction relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:19667122
PR:000037185 hCTNNB1/iso:1/UnPhos:2
UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291		 enablesGO:0003713 transcription coactivator activity PMID:20419129
GO:0005515 protein binding PMID:20419129
located_inGO:0005634 nucleus PMID:20419129
PR:000037190 hCTNNB1/iso:1/Phos:7
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047		 acts_upstream_of_or_withindecreased GO:0007155 cell adhesion relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
GO:0010631 epithelial cell migration PMID:21152425
decreased GO:0034333 adherens junction assembly relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:20419129
NOT GO:0005515 protein binding with PR:Q9HCS4 HMG box transcription factor 3 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9NQB0 HMG box transcription factor 4 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9UJU2 hLEF1 PMID:21152425
NOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:21152425
NOT GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:21152425
NOT GO:0005515 protein binding PMID:21152425
located_inGO:0005737 cytoplasm PMID:20419129
decreased GO:0005912 adherens junction relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
PR:000037192 hCTNNB1/iso:1/Phos:8
UniProtKB:P35222-1, Tyr-333, MOD:00048		 acts_upstream_of_or_withinGO:0007173 epidermal growth factor receptor signaling pathway PMID:22056988
enablesGO:0003713 transcription coactivator activity PMID:22056988
GO:0005515 protein binding PMID:22056988
located_inGO:0005634 nucleus PMID:22056988
PR:000037194 hCTNNB1/iso:1/Phos:9
UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048		 enablesincreased GO:0017025 TBP-class protein binding with PR:P20226 GTF2D1 PMID:11279024
decreased GO:0045296 cadherin binding relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 PMID:11279024
PR:000037515 hCTNNB1/iso:1/Phos:11
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046		 acts_upstream_of_or_withindecreased GO:0008283 cell population proliferation relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
decreased GO:0060070 canonical Wnt signaling pathway relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
increased GO:0005515 protein binding relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:16996060; PMID:21152425; PMID:23071615
PR:000044474 hCTNNB1/iso:1/Phos:12
UniProtKB:P35222-1, Thr-393, MOD:00047		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:12700239
GO:0045944 positive regulation of transcription by RNA polymerase II PMID:12700239
enablesdecreased GO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044476 hCTNNB1/iso:1/UnPhos:7
UniProtKB:P35222-1, Thr-393, PR:000026291		 enablesGO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044478 hCTNNB1/iso:1/Phos:13
UniProtKB:P35222-1, Tyr-654, MOD:00048		 enablesGO:0003713 transcription coactivator activity PMID:23640056
PR:000044510 hCTNNB1/iso:1/Phos:14
UniProtKB:P35222-1, Ser-552, MOD:00046		 enablesGO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:17287208