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Protein Ontology report - caspase-8
PR:000002317 - http://purl.obolibrary.org/obo/PR_000002317
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002317   
  PRO namecaspase-8 
  Synonyms
PRO-Short-label: EXACT:CASP8
Gene-based: RELATED:MCH5
Other: EXACT:apoptotic cysteine protease | apoptotic protease Mch-5 | CAP4 | CASP-8 | FADD-homologous ICE/ced-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MORT1-associated ced-3 homolog
  Definition"A caspase-8-like protease that is a translation product of the human CASP8 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002197 caspase-8-like protease
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence9                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500656;IUPHARobj:1624
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002317
caspase-8
CASP8
"A caspase-8-like protease that is a translation product of the human CASP8 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:O89110
caspase-8 (mouse)
mCASP8
"A caspase-8 that is encoded in the genome of mouse." [OMA:O89110, PRO:DNx]

organism-sequence


PR:O89110-1
caspase-8 isoform 1 (mouse)
mCASP8/iso:1
"A caspase-8 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q14790
caspase-8 (human)
hCASP8
"A caspase-8 that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:Q14790-1
caspase-8 isoform 1 (human)
hCASP8/iso:1
"A caspase-8 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000036063
caspase-8 isoform 1 cleaved 1 (human)
hCASP8/iso:1/Clv:1
"A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA]

Yes
organism-modification


PR:000036065
caspase-8 isoform 1 cleaved 2 (human)
hCASP8/iso:1/Clv:2
"A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA]

Yes
organism-sequence


PR:Q14790-2
caspase-8 isoform 2 (human)
hCASP8/iso:2
"A caspase-8 isoform 2 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-3
caspase-8 isoform 3 (human)
hCASP8/iso:3
"A caspase-8 isoform 3 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-4
caspase-8 isoform 4 (human)
hCASP8/iso:4
"A caspase-8 isoform 4 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-5
caspase-8 isoform 5 (human)
hCASP8/iso:5
"A caspase-8 isoform 5 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-6
caspase-8 isoform 6 (human)
hCASP8/iso:6
"A caspase-8 isoform 6 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-7
caspase-8 isoform 7 (human)
hCASP8/iso:7
"A caspase-8 isoform 7 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-8
caspase-8 isoform 8 (human)
hCASP8/iso:8
"A caspase-8 isoform 8 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q14790-9
caspase-8 isoform 9 (human)
hCASP8/iso:9
"A caspase-8 isoform 9 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000045931
caspase-8 phosphorylated 1 (human)
hCASP8/Phos:1
"A caspase-8 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-380 of the amino acid sequence represented by UniProtKB:Q14790-1. Example: UniProtKB:Q14790-1, Tyr-380, MOD:00048." [iPTMnet:Q14790, PMID:16619028, PMID:19851329]

organism-gene


PR:Q9JHX4
caspase-8 (rat)
rCASP8
"A caspase-8 that is encoded in the genome of rat." [OMA:Q9JHX4, PRO:DNx]

sequence


PR:000002412
caspase-8 isoform 1
CASP8/iso:1
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:O89110-1
caspase-8 isoform 1 (mouse)
mCASP8/iso:1
"A caspase-8 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:Q14790-1
caspase-8 isoform 1 (human)
hCASP8/iso:1
"A caspase-8 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000036063
caspase-8 isoform 1 cleaved 1 (human)
hCASP8/iso:1/Clv:1
"A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA]

Yes
organism-modification


PR:000036065
caspase-8 isoform 1 cleaved 2 (human)
hCASP8/iso:1/Clv:2
"A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA]

Yes
modification


PR:000036062
caspase-8 isoform 1 cleaved 1
CASP8/iso:1/Clv:1
"A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p18." [PRO:CNA]

organism-modification


PR:000036063
caspase-8 isoform 1 cleaved 1 (human)
hCASP8/iso:1/Clv:1
"A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA]

Yes
modification


PR:000036064
caspase-8 isoform 1 cleaved 2
CASP8/iso:1/Clv:2
"A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p10." [PRO:CNA]

organism-modification


PR:000036065
caspase-8 isoform 1 cleaved 2 (human)
hCASP8/iso:1/Clv:2
"A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA]

Yes
sequence


PR:000002413
caspase-8 isoform 2
CASP8/iso:2
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-2
caspase-8 isoform 2 (human)
hCASP8/iso:2
"A caspase-8 isoform 2 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002414
caspase-8 isoform 3
CASP8/iso:3
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-3 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-3
caspase-8 isoform 3 (human)
hCASP8/iso:3
"A caspase-8 isoform 3 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002415
caspase-8 isoform 4
CASP8/iso:4
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-4 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-4
caspase-8 isoform 4 (human)
hCASP8/iso:4
"A caspase-8 isoform 4 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002416
caspase-8 isoform 5
CASP8/iso:5
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-5 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-5
caspase-8 isoform 5 (human)
hCASP8/iso:5
"A caspase-8 isoform 5 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002417
caspase-8 isoform 6
CASP8/iso:6
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-6 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-6
caspase-8 isoform 6 (human)
hCASP8/iso:6
"A caspase-8 isoform 6 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002418
caspase-8 isoform 7
CASP8/iso:7
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-7 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-7
caspase-8 isoform 7 (human)
hCASP8/iso:7
"A caspase-8 isoform 7 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002419
caspase-8 isoform 8
CASP8/iso:8
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-8 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-8
caspase-8 isoform 8 (human)
hCASP8/iso:8
"A caspase-8 isoform 8 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002420
caspase-8 isoform 9
CASP8/iso:9
"A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-9 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q14790-9
caspase-8 isoform 9 (human)
hCASP8/iso:9
"A caspase-8 isoform 9 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000018768
caspase-8 proteolytic cleavage product
CASP8/ClvPrd
"A caspase-8 that has been processed by proteolytic cleavage." [PRO:DNx]

modification


PR:000036062
caspase-8 isoform 1 cleaved 1
CASP8/iso:1/Clv:1
"A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p18." [PRO:CNA]

organism-modification


PR:000036063
caspase-8 isoform 1 cleaved 1 (human)
hCASP8/iso:1/Clv:1
"A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA]

Yes
modification


PR:000036064
caspase-8 isoform 1 cleaved 2
CASP8/iso:1/Clv:2
"A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p10." [PRO:CNA]

organism-modification


PR:000036065
caspase-8 isoform 1 cleaved 2 (human)
hCASP8/iso:1/Clv:2
"A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA]

Yes
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CASP8 forms found in complexes   

CASP8 Component
 Complexes
PR:000036063 hCASP8/iso:1/Clv:1 PR:000036068 caspase-8 complex (human)
PR:000036065 hCASP8/iso:1/Clv:2 PR:000036068 caspase-8 complex (human)
PR:Q14790 hCASP8 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)