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Protein Ontology report - caspase-1
PR:000002309 - http://purl.obolibrary.org/obo/PR_000002309
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000002309   
  PRO namecaspase-1 
  Synonyms
PRO-Short-label: EXACT:CASP1
Gene-based: RELATED:IL1BC | IL1BCE
Other: EXACT:CASP-1 | ICE | IL-1 beta-converting enzyme | IL-1BC | interleukin-1 beta convertase | interleukin-1 beta-converting enzyme
  Definition"A caspase-1-like protease that is a translation product of the human CASP1 gene or a 1:1 ortholog thereof. The active form of this protein proteolytically cleaves pro-IL-1beta to its mature, active form. The holoenzyme is a homodimer of catalytic domains, each of which contains the cleaved products caspase-1 p20 and p10 subunits." [PMID:8044845, PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002195 caspase-1-like protease
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence6                                                  Organism-Sequence 6                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1617
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002309 caspase-1
CASP1

organism-gene


PR:P29452 caspase-1 (mouse)
mCASP1

organism-sequence


PR:P29452-1 caspase-1 isoform 1 (mouse)
mCASP1/iso:1

organism-modification


PR:000078346 caspase-1 cysteinylated 1 (mouse)
mCASP1/Cyst:1

organism-gene


PR:P29466 caspase-1 (human)
hCASP1

organism-sequence


PR:P29466-1 caspase-1 isoform alpha (human)
hCASP1/iso:alpha

organism-sequence


PR:P29466-2 caspase-1 isoform beta (human)
hCASP1/iso:beta

organism-sequence


PR:P29466-3 caspase-1 isoform gamma (human)
hCASP1/iso:gamma

organism-sequence


PR:P29466-4 caspase-1 isoform delta (human)
hCASP1/iso:delta

organism-sequence


PR:P29466-5 caspase-1 isoform epsilon (human)
hCASP1/iso:epsilon

organism-modification


PR:000079348 caspase-1 cysteinylated 1 (human)
hCASP1/Cyst:1

organism-gene


PR:P43527 caspase-1 (rat)
rCASP1

sequence


PR:000002390 caspase-1 isoform 1
CASP1/iso:1

organism-sequence


PR:P29452-1 caspase-1 isoform 1 (mouse)
mCASP1/iso:1

organism-sequence


PR:P29466-1 caspase-1 isoform alpha (human)
hCASP1/iso:alpha

modification


PR:000002449 caspase-1 isoform 1 cleaved 1
CASP1/iso:1/Clv:1

modification


PR:000002450 caspase-1 isoform 1 cleaved 2
CASP1/iso:1/Clv:2

sequence


PR:000002391 caspase-1 isoform 2
CASP1/iso:2

organism-sequence


PR:P29466-2 caspase-1 isoform beta (human)
hCASP1/iso:beta

sequence


PR:000002392 caspase-1 isoform 3
CASP1/iso:3

organism-sequence


PR:P29466-3 caspase-1 isoform gamma (human)
hCASP1/iso:gamma

sequence


PR:000002393 caspase-1 isoform 4
CASP1/iso:4

organism-sequence


PR:P29466-4 caspase-1 isoform delta (human)
hCASP1/iso:delta

sequence


PR:000002394 caspase-1 isoform 5
CASP1/iso:5

organism-sequence


PR:P29466-5 caspase-1 isoform epsilon (human)
hCASP1/iso:epsilon

sequence


PR:000002395 caspase-1 isoform 6
CASP1/iso:6

modification


PR:000018758 caspase-1 proteolytic cleavage product
CASP1/ClvPrd

modification


PR:000002449 caspase-1 isoform 1 cleaved 1
CASP1/iso:1/Clv:1

modification


PR:000002450 caspase-1 isoform 1 cleaved 2
CASP1/iso:1/Clv:2