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Protein Ontology report - Bcl-2-like protein 1

PR:000002308 - http://purl.obolibrary.org/obo/PR_000002308

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000002308

PRO name

Bcl-2-like protein 1

Synonyms

PRO-Short-label:	EXACT:	BCL2L1
Gene-based:	RELATED:	BCL2L \| BCLX
Other:	EXACT:	apoptosis regulator Bcl-X \| Bcl2-L-1

Definition

"A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2L1 gene or a 1:1 ortholog thereof." [PRO:WCB]

PRO Category

gene

Parent

PR:000002186 Bcl-2-like apoptosis inhibitor

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	4
Sequence	5	Organism-Sequence	12
Modification	0	Organism-Modification	1

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	IUPHARobj:2845

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000002308 Bcl-2-like protein 1

BCL2L1

organism-gene

PR:P53563 Bcl-2-like protein 1 (rat)

rBCL2L1

organism-sequence

PR:P53563-1 Bcl-2-like protein 1 isoform Bcl-X(L) (rat)

rBcl2l1/iso:Bcl-X(L)

organism-sequence

PR:P53563-2 Bcl-2-like protein 1 isoform Bcl-X(S) (rat)

rBCL2L1/iso:Bcl-X(S)

organism-sequence

PR:P53563-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (rat)

rBCL2L1/iso:Bcl-X(beta)

organism-gene

PR:Q07816 Bcl-2-like protein 1 (chicken)

chick-BCL2L1

organism-sequence

PR:Q07816-1 Bcl-2-like protein 1 isoform Long (chicken)

chick-BCL2L1/iso:Long

organism-sequence

PR:Q07816-2 Bcl-2-like protein 1 isoform Short (chicken)

chick-BCL2L1/iso:Short

organism-gene

PR:Q07817 Bcl-2-like protein 1 (human)

hBCL2L1

organism-sequence

PR:Q07817-1 Bcl-2-like protein 1 isoform 1 (human)

hBCL2L1/iso:1

Yes

organism-sequence

PR:Q07817-2 Bcl-2-like protein 1 isoform Bcl-X(S) (human)

hBCL2L1/iso:Bcl-X(S)

organism-sequence

PR:Q07817-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (human)

hBCL2L1/iso:Bcl-X(beta)

organism-modification

PR:000045887 Bcl-2-like protein 1 phosphorylated 1 (human)

hBCL2L1/Phos:1

organism-gene

PR:Q64373 Bcl-2-like protein 1 (mouse)

mBCL2L1

organism-sequence

PR:Q64373-1 Bcl-2-like protein 1 isoform Bcl-X(L) (mouse)

mBCL2L1/iso:Bcl-X(L)

Yes

organism-sequence

PR:Q64373-2 Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)

mBCL2L1/iso:Bcl-X(S)

Yes

organism-sequence

PR:Q64373-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (mouse)

mBCL2L1/iso:Bcl-X(beta)

organism-sequence

PR:Q64373-4 Bcl-2-like protein 1 isoform Bcl-X(delta-TM) (mouse)

mBCL2L1/iso:Bcl-X(delta-TM)

sequence

PR:000002385 Bcl-2-like protein 1 isoform 1

BCL2L1/iso:1

organism-sequence

PR:Q07817-1 Bcl-2-like protein 1 isoform 1 (human)

hBCL2L1/iso:1

Yes

organism-sequence

PR:Q64373-1 Bcl-2-like protein 1 isoform Bcl-X(L) (mouse)

mBCL2L1/iso:Bcl-X(L)

Yes

sequence

PR:000002386 Bcl-2-like protein 1 isoform 2

BCL2L1/iso:2

organism-sequence

PR:Q07817-2 Bcl-2-like protein 1 isoform Bcl-X(S) (human)

hBCL2L1/iso:Bcl-X(S)

organism-sequence

PR:Q64373-2 Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)

mBCL2L1/iso:Bcl-X(S)

Yes

sequence

PR:000002387 Bcl-2-like protein 1 isoform 3

BCL2L1/iso:3

organism-sequence

PR:Q07817-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (human)

hBCL2L1/iso:Bcl-X(beta)

sequence

PR:000002388 Bcl-2-like protein 1 isoform 4

BCL2L1/iso:4

organism-sequence

PR:Q64373-3 Bcl-2-like protein 1 isoform Bcl-X(beta) (mouse)

mBCL2L1/iso:Bcl-X(beta)

sequence

PR:000002389 Bcl-2-like protein 1 isoform 5

BCL2L1/iso:5

organism-sequence

PR:Q64373-4 Bcl-2-like protein 1 isoform Bcl-X(delta-TM) (mouse)

mBCL2L1/iso:Bcl-X(delta-TM)

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0006915 apoptotic process	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
GO:0043065 positive regulation of apoptotic process	PR:Q64373-2 mBCL2L1/iso:Bcl-X(S)	MGI_ref:81233; PMID:8798158
GO:0043066 negative regulation of apoptotic process	PR:Q07817-1 hBCL2L1/iso:1	PMID:8596636
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:81233; PMID:8798158
Disease Associated GO Term	Protein Forms & Complexes	Evidence
DO:162 cancer	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	PMID:16403219
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0005515 protein binding	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:3804133; PMID:16705087
NOT GO:0005515 protein binding	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
	PR:Q07817-1 hBCL2L1/iso:1	PMID:10949026
GO:0046982 protein heterodimerization activity	PR:Q64373-1 mBCL2L1/iso:Bcl-X(L)	MGI_ref:82784; PMID:8798452