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Protein Ontology report - TNF receptor-associated factor 3
PR:000002289 - http://purl.obolibrary.org/obo/PR_000002289
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002289   
  PRO nameTNF receptor-associated factor 3 
  Synonyms
PRO-Short-label: EXACT:TRAF3
Gene-based: RELATED:CAP-1 | CAP1 | CRAF1 | TRAFAMN
Other: EXACT:CD40 receptor-associated factor 1 | CD40-binding protein | CD40BP | LAP1 | LMP1-associated protein 1 | RING-type E3 ubiquitin transferase TRAF3
  Definition"A TNF receptor-associated factor that is a translation product of the human TRAF3 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002191 TNF receptor-associated factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002289
TNF receptor-associated factor 3
TRAF3
"A TNF receptor-associated factor that is a translation product of the human TRAF3 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:Q13114
TNF receptor-associated factor 3 (human)
hTRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of human." [PRO:CNA]

Yes
organism-sequence


PR:Q13114-1
TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q13114-2
TNF receptor-associated factor 3 isoform h2 (human)
hTRAF3/iso:h2
"A TNF receptor-associated factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13114-2." [PRO:DNx, UniProtKB:Q13114]

organism-modification


PR:000036032
TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+
"A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772." [Reactome:R-HSA-936402]

Yes
organism-modification


PR:000064750
TNF receptor-associated factor 3 ubiquitinated form (human)
hTRAF3/UbiqLys+
"A TNF receptor-associated factor 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q13114, MOD:01148." [PRO:DNx, Reactome:R-HSA-936556]

organism-modification


PR:000069328
TNF receptor-associated factor 3 cysteinylated 1 (human)
hTRAF3/Cyst:1
"A TNF receptor-associated factor 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13114-1. Example: UniProtKB:Q13114-1, Cys-117, MOD:00765." [IEDB_epitope:1578434, PRO:DNx]

organism-modification


PR:000083316
TNF receptor-associated factor 3 deaminated 1 (human)
hTRAF3/Deam:1
"A TNF receptor-associated factor 3 (human) that has been deaminated on the residue at the position equivalent to Gln-278 of the amino acid sequence represented by UniProtKB:Q13114-1. Example: UniProtKB:Q13114-1, Gln-278, MOD:00685." [IEDB_epitope:1777217, PRO:DNx]

organism-gene


PR:Q54FC5
TNF receptor-associated factor family protein DDB_G0290965 (Dictyostelium discoideum)
Dicty-TRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54FC5, PRO:DNx]

organism-gene


PR:Q60803
TNF receptor-associated factor 3 (mouse)
mTRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of mouse." [OMA:Q60803, PRO:CNA]

Yes
organism-sequence


PR:Q60803-1
TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

sequence


PR:000002377
TNF receptor-associated factor 3 isoform 1
TRAF3/iso:1
"A TNF receptor-associated factor 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13114-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q13114-1
TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q60803-1
TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

modification


PR:000036031
TNF receptor-associated factor 3 K63-polyubiquitinated form
TRAF3/K63polyUbiqLys+
"A TNF receptor-associated factor 3 that has been cross-linked to K63-linked polyubiquitin. Example: UniProtKB:Q13114, PR:000044772." [PRO:CNA]

organism-modification


PR:000036032
TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+
"A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772." [Reactome:R-HSA-936402]

Yes
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TRAF3 forms found in complexes   

TRAF3 Component
 Complexes
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q60803 mTRAF3 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)