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Protein Ontology report - TNF receptor-associated factor 2
PR:000002288 - http://purl.obolibrary.org/obo/PR_000002288
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002288   
  PRO nameTNF receptor-associated factor 2 
  Synonyms
PRO-Short-label: EXACT:TRAF2
Gene-based: RELATED:TRAP3
Other: EXACT:E3 ubiquitin-protein ligase TRAF2 | RING-type E3 ubiquitin transferase TRAF2 | tumor necrosis factor type 2 receptor-associated protein 3
  Definition"A TNF receptor-associated factor that is a translation product of the human TRAF2 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002191 TNF receptor-associated factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification2                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002288
TNF receptor-associated factor 2
TRAF2
"A TNF receptor-associated factor that is a translation product of the human TRAF2 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:P39429
TNF receptor-associated factor 2 (mouse)
mTRAF2
"A TNF receptor-associated factor 2 that is encoded in the genome of mouse." [OMA:P39429, PRO:DNx]

organism-sequence


PR:P39429-1
TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:P39429-2
TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q12933
TNF receptor-associated factor 2 (human)
hTRAF2
"A TNF receptor-associated factor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q12933]

organism-sequence


PR:Q12933-1
TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q12933-2
TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 3 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q12933-3
TNF receptor-associated factor 2 isoform h3 (human)
hTRAF2/iso:h3
"A TNF receptor-associated factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-3." [PRO:DNx, UniProtKB:Q12933]

organism-sequence


PR:Q12933-4
TNF receptor-associated factor 2 isoform h4 (human)
hTRAF2/iso:h4
"A TNF receptor-associated factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-4." [PRO:DNx, UniProtKB:Q12933]

organism-modification


PR:000028382
TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-
"A TNF receptor-associated factor 2, initiator methionine removed form in human. Example: UniProtKB:Q12933-1, 2-501." [PRO:DNx]

Yes
organism-modification


PR:000049534
TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+
"A TNF receptor-associated factor 2, initiator methionine removed form (human) that includes at least one ubiquitinated lysine. UniProtKB:Q12933, 2-501, MOD:01148." [PRO:DNx, Reactome:R-HSA-8862194]

organism-modification


PR:000045896
TNF receptor-associated factor 2 phosphorylated 1 (human)
hTRAF2/Phos:1
"A TNF receptor-associated factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-55 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Ser-55, MOD:00046." [iPTMnet:Q12933, PMID:19336568]

organism-modification


PR:000069067
TNF receptor-associated factor 2 cysteinylated 1 (human)
hTRAF2/Cyst:1
"A TNF receptor-associated factor 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-34 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Cys-34, MOD:00765." [IEDB_epitope:1577094, PRO:DNx]

organism-modification


PR:000079608
TNF receptor-associated factor 2 methylated 1 (human)
hTRAF2/Me:1
"A TNF receptor-associated factor 2 (human) that has been methylated on the residue at the position equivalent to Cys-182 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Cys-182, MOD:00660." [IEDB_epitope:999579, PRO:DNx]

sequence


PR:000002374
TNF receptor-associated factor 2 isoform 1
TRAF2/iso:1
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P39429-1
TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:Q12933-1
TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000026641
TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-
"A TNF receptor-associated factor 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

sequence


PR:000002375
TNF receptor-associated factor 2 isoform 2
TRAF2/iso:2
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39429-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P39429-2
TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

sequence


PR:000002376
TNF receptor-associated factor 2 isoform 3
TRAF2/iso:3
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q12933-2
TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 3 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000018757
TNF receptor-associated factor 2, initiator methionine removed form
TRAF2/InitMet-
"A TNF receptor-associated factor 2 that has had the initiator methionine removed." [PRO:DNx]

modification


PR:000026641
TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-
"A TNF receptor-associated factor 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000028382
TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-
"A TNF receptor-associated factor 2, initiator methionine removed form in human. Example: UniProtKB:Q12933-1, 2-501." [PRO:DNx]

Yes
organism-modification


PR:000049534
TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+
"A TNF receptor-associated factor 2, initiator methionine removed form (human) that includes at least one ubiquitinated lysine. UniProtKB:Q12933, 2-501, MOD:01148." [PRO:DNx, Reactome:R-HSA-8862194]

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TRAF2 forms found in complexes   

TRAF2 Component
 Complexes
PR:000028382 hTRAF2/InitMet- PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)