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Protein Ontology report - Bcl2-associated agonist of cell death isoform 1
PR:000002280 - http://purl.obolibrary.org/obo/PR_000002280
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002280   
  PRO nameBcl2-associated agonist of cell death isoform 1 
  Synonyms
PRO-Short-label: EXACT:BAD/iso:1
Other: EXACT:BAD isoform alpha | bcl-xL/Bcl-2-associated death promoter
  Definition"A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61337-1 or a 1:1 ortholog thereof." [PRO:JAN] 
  PRO Categorysequence 
  ParentPR:000002184 Bcl2-associated agonist of cell death
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification10                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000002280

Bcl2-associated agonist of cell death isoform 1

BAD/iso:1


"A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61337-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O35147-1

Bcl2-associated agonist of cell death isoform Alpha (rat)

rBAD/iso:Alpha


"A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of rat." [PRO:JAN]

Yes

organism-modification



PR:000026134

Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat)

rBAD/iso:1/Phos:3


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN]

Yes

organism-modification



PR:000044748

Bcl2-associated agonist of cell death isoform 1 unmodified form (rat)

rBAD/iso:1/UnMod


"A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx]

Yes

organism-sequence



PR:Q61337-1

Bcl2-associated agonist of cell death isoform 1 (mouse)

mBAD/iso:1


"A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000026133

Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse)

mBAD/iso:1/Phos:2


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN]

Yes

organism-modification



PR:000026135

Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse)

mBAD/iso:1/Phos:4


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]

Yes

organism-modification



PR:000026136

Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse)

mBAD/iso:1/Phos:5


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

Yes

organism-modification



PR:000026137

Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse)

mBAD/iso:1/Phos:6


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

Yes

organism-modification



PR:000026138

Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse)

mBAD/iso:1/Phos:7


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]


organism-modification



PR:000026139

Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse)

mBAD/iso:1/Phos:8


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

Yes

organism-modification



PR:000026167

Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse)

mBAD/iso:1/Phos:1


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN]

Yes

organism-modification



PR:000037809

Bcl2-associated agonist of cell death isoform 1 unphosphorylated 1 (mouse)

mBAD/iso:1/UnPhos:1


"A Bcl2-associated agonist of cell death isoform 1 (mouse) that lacks phosphorylation on the indicated Ser residues located within each of two RxRxxSxP motifs, and the indicated Ser residue within the motif RRxS in the BH3 domain, which is the major PKA phosphorylation site. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, PR:000026291." [PMID:16403219, PRO:DAN, PRO:KER]


organism-modification



PR:000044747

Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse)

mBAD/iso:1/UnMod


"A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx]

Yes

modification



PR:000002843

Bcl2-associated agonist of cell death isoform 1 unmodified form

BAD/iso:1/UnMod


"A Bcl2-associated agonist of cell death isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


organism-modification



PR:000044747

Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse)

mBAD/iso:1/UnMod


"A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx]

Yes

organism-modification



PR:000044748

Bcl2-associated agonist of cell death isoform 1 unmodified form (rat)

rBAD/iso:1/UnMod


"A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx]

Yes

modification



PR:000003084

Bcl2-associated agonist of cell death isoform 1 phosphorylated form

BAD/iso:1/PhosRes+


"A Bcl2-associated agonist of cell death isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003085

Bcl2-associated agonist of cell death isoform 1 phosphorylated 1

BAD/iso:1/Phos:1


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues which are the major sites of phosphorylation by PKA and AKT signaling. The sites are the indicated serines within the RxRxxSxP motifs. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:CNA, PRO:DAN, PRO:JAN]


organism-modification



PR:000026167

Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse)

mBAD/iso:1/Phos:1


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN]

Yes

modification



PR:000003086

Bcl2-associated agonist of cell death isoform 1 phosphorylated 2

BAD/iso:1/Phos:2


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at the indicated Ser residues within each of two RxRxxSxP motifs, and within the RRxS motif located in the BH3 domain. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:CNA, PRO:DAN, PRO:JAN]


organism-modification



PR:000026133

Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse)

mBAD/iso:1/Phos:2


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN]

Yes

modification



PR:000003087

Bcl2-associated agonist of cell death isoform 1 phosphorylated 3

BAD/iso:1/Phos:3


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs upon activation of the MAPK pathway. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PMID:10880354, PRO:JAN]


organism-modification



PR:000026134

Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat)

rBAD/iso:1/Phos:3


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN]

Yes

modification



PR:000003233

Bcl2-associated agonist of cell death isoform 1 phosphorylated 4

BAD/iso:1/Phos:4


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue by the action of JNK1. Example: UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]


organism-modification



PR:000026135

Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse)

mBAD/iso:1/Phos:4


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]

Yes

modification



PR:000003238

Bcl2-associated agonist of cell death isoform 1 phosphorylated 5

BAD/iso:1/Phos:5


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at one of the two Ser residues which are the major sites of phosphorylation by MAPK and AKT signaling. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]


organism-modification



PR:000026136

Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse)

mBAD/iso:1/Phos:5


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

Yes

modification



PR:000003269

Bcl2-associated agonist of cell death isoform 1 phosphorylated 6

BAD/iso:1/Phos:6


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs by the action of cdc-2. Example: UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]


organism-modification



PR:000026137

Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse)

mBAD/iso:1/Phos:6


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]

Yes

modification



PR:000025849

Bcl2-associated agonist of cell death isoform 1 phosphorylated 7

BAD/iso:1/Phos:7


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues by activation of RSK. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]


organism-modification



PR:000026138

Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse)

mBAD/iso:1/Phos:7


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]


modification



PR:000025850

Bcl2-associated agonist of cell death isoform 1 phosphorylated 8

BAD/iso:1/Phos:8


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue at the PKA/RSK consensus sequence RRxS. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]


organism-modification



PR:000026139

Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse)

mBAD/iso:1/Phos:8


"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006915 apoptotic processPR:000044747 mBAD/iso:1/UnMod PMID:15280015
GO:0043066 negative regulation of apoptotic processPR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
PR:000026135 mBAD/iso:1/Phos:4 PMID:14967141
GO:0043525 positive regulation of neuron apoptotic processPR:O35147-1 rBAD/iso:Alpha PMID:11161472
GO:0051402 neuron apoptotic processPR:000026137 mBAD/iso:1/Phos:6 PMID:12049737

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:000026134 rBAD/iso:1/Phos:3 PMID:10195903
PR:000026135 mBAD/iso:1/Phos:4 PMID:14967141
PR:000026136 mBAD/iso:1/Phos:5 PMID:12049737
PR:000026167 mBAD/iso:1/Phos:1 PMID:12049737
PR:000026167 mBAD/iso:1/Phos:1 PMID:12049737
PR:000026167 mBAD/iso:1/Phos:1 PMID:12049737
PR:000026167 mBAD/iso:1/Phos:1 PMID:12049737
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044747 mBAD/iso:1/UnMod PMID:17011751
PR:000044748 rBAD/iso:1/UnMod PMID:10195903
PR:O35147-1 rBAD/iso:Alpha PMID:11161472
NOT GO:0005515 protein bindingPR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
PR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
PR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
PR:000026133 mBAD/iso:1/Phos:2 PMID:10949026
GO:0019902 phosphatase bindingPR:000026134 rBAD/iso:1/Phos:3 PMID:10195903
PR:000044748 rBAD/iso:1/UnMod PMID:10195903
GO:0071889 14-3-3 protein bindingPR:000026139 mBAD/iso:1/Phos:8 PMID:10880354

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005739 mitochondrionPR:000044748 rBAD/iso:1/UnMod PMID:10195903
GO:0005829 cytosolPR:000026134 rBAD/iso:1/Phos:3 PMID:10195903
GO:0031966 mitochondrial membranePR:000044747 mBAD/iso:1/UnMod PMID:15280015