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Protein Ontology report - apoptosis regulator BAX
PR:000002193 - http://purl.obolibrary.org/obo/PR_000002193
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002193   
  PRO nameapoptosis regulator BAX 
  Synonyms
PRO-Short-label: EXACT:BAX
Gene-based: RELATED:BCL2L4
Other: EXACT:Bcl-2-like protein 4 | Bcl2-L-4
  Definition"A protein that is a translation product of the human BAX gene or a 1:1 ortholog thereof. In this class the Bcl-2 domain is characterized by the presence of the BH3, BH1, and BH2 motifs." [PRO:SY, PRO:WCB] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence8                                                  Organism-Sequence 15                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038828
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002193

apoptosis regulator BAX

BAX


"A protein that is a translation product of the human BAX gene or a 1:1 ortholog thereof. In this class the Bcl-2 domain is characterized by the presence of the BH3, BH1, and BH2 motifs." [PRO:SY, PRO:WCB]


organism-gene



PR:Q07812

apoptosis regulator BAX (human)

hBAX


"An apoptosis regulator BAX that is encoded in the genome of human." [PRO:SY, UniProtKB:Q07812]


organism-sequence



PR:Q07812-1

apoptosis regulator BAX isoform alpha (human)

hBAX/iso:alpha


"An apoptosis regulator BAX isoform 1 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-2

apoptosis regulator BAX isoform beta (human)

hBAX/iso:beta


"An apoptosis regulator BAX isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-3

apoptosis regulator BAX isoform gamma (human)

hBAX/iso:gamma


"An apoptosis regulator BAX isoform 3 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-4

apoptosis regulator BAX isoform delta (human)

hBAX/iso:delta


"An apoptosis regulator BAX isoform 4 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-5

apoptosis regulator BAX isoform epsilon (human)

hBAX/iso:epsilon


"An apoptosis regulator BAX isoform 5 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-6

apoptosis regulator BAX isoform zeta (human)

hBAX/iso:zeta


"An apoptosis regulator BAX isoform 6 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-7

apoptosis regulator BAX isoform psi (human)

hBAX/iso:psi


"An apoptosis regulator BAX isoform 7 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-8

apoptosis regulator BAX isoform sigma (human)

hBAX/iso:sigma


"An apoptosis regulator BAX isoform 8 that is encoded in the genome of human." [PRO:SY]


organism-modification



PR:000036214

apoptosis regulator BAX acetylated 1 (human)

hBAX/Ac:1


"An apoptosis regulator BAX (human) that is N-terminal Met acetylated. Example: UniProtKB:Q07812-1, Met-1, MOD:00058." [TDR:1457]


organism-modification



PR:000045886

apoptosis regulator BAX phosphorylated 1 (human)

hBAX/Phos:1


"An apoptosis regulator BAX (human) that has been phosphorylated on the residue at the position equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:Q07812-1. Example: UniProtKB:Q07812-1, Thr-167, MOD:00047." [iPTMnet:Q07812, PMID:19182807]


organism-modification



PR:000081293

apoptosis regulator BAX methylated 1 (human)

hBAX/Me:1


"An apoptosis regulator BAX (human) that has been methylated on the residue at the position equivalent to Cys-126 of the amino acid sequence represented by UniProtKB:Q07812-1. Example: UniProtKB:Q07812-1, Cys-126, MOD:00660." [IEDB_epitope:1000223, PRO:DNx]


organism-gene



PR:Q07813

apoptosis regulator BAX (mouse)

mBAX


"An apoptosis regulator BAX that is encoded in the genome of mouse." [OMA:Q07813, PRO:SY, PRO:WCB]


organism-sequence



PR:Q07813-1

apoptosis regulator BAX isoform Alpha (mouse)

mBAX/iso:Alpha


"An apoptosis regulator BAX isoform 1 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]

Yes

organism-sequence



PR:Q07813-2

apoptosis regulator BAX isoform Beta (mouse)

mBAX/iso:Beta


"An apoptosis regulator BAX (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07813-2." [PRO:DNx, UniProtKB:Q07813]


organism-sequence



PR:Q07813-3

apoptosis regulator BAX isoform Gamma (mouse)

mBAX/iso:Gamma


"An apoptosis regulator BAX (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07813-3." [PRO:DNx, UniProtKB:Q07813]


organism-sequence



PR:Q8K3J2

Bcl2-associated X protein kappa isoform (mouse)

mBAX/iso:7


"An apoptosis regulator BAX isoform 7 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]


organism-modification



PR:000036213

apoptosis regulator BAX acetylated 1 (mouse)

mBAX/Ac:1


"An apoptosis regulator BAX (mouse) that is N-terminal Met acetylated. Example: UniProtKB:Q07813-1, Met-1, MOD:00058." [TDR:9284]


organism-gene



PR:Q63690

apoptosis regulator BAX (rat)

rBAX


"An apoptosis regulator BAX that is encoded in the genome of rat." [OMA:Q63690, PRO:DNx]


organism-sequence



PR:Q63690-1

apoptosis regulator BAX isoform Alpha (rat)

rBAX/iso:Alpha


"An apoptosis regulator BAX (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63690-1." [PRO:DNx, UniProtKB:Q63690]


organism-sequence



PR:Q63690-2

apoptosis regulator BAX isoform Beta (rat)

rBAX/iso:Beta


"An apoptosis regulator BAX (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63690-2." [PRO:DNx, UniProtKB:Q63690]


organism-sequence



PR:Q63690-3

apoptosis regulator BAX isoform Gamma (rat)

rBAX/iso:Gamma


"An apoptosis regulator BAX (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63690-3." [PRO:DNx, UniProtKB:Q63690]


sequence



PR:000002299

apoptosis regulator BAX isoform 1

BAX/iso:1


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-1 or a 1:1 ortholog thereof. It contains one copy of the Bcl-2 domain, and a C-terminal single transmembrane domain." [PMID:8358790, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-1

apoptosis regulator BAX isoform alpha (human)

hBAX/iso:alpha


"An apoptosis regulator BAX isoform 1 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07813-1

apoptosis regulator BAX isoform Alpha (mouse)

mBAX/iso:Alpha


"An apoptosis regulator BAX isoform 1 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]

Yes

modification



PR:000003267

apoptosis regulator BAX isoform 1 phosphorylated form

BAX/iso:1/PhosRes+


"An apoptosis regulator BAX isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003268

apoptosis regulator BAX isoform 1 phosphorylated 1

BAX/iso:1/Phos:1


"An apoptosis regulator BAX isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue upon AKT activation. Example: UniProtKB:Q07813-1, Ser-184, MOD:00046." [PMID:14766748, PRO:JAN]


sequence



PR:000002300

apoptosis regulator BAX isoform 2

BAX/iso:2


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-2 or a 1:1 ortholog thereof. It lacks the transmembrane domain due to the presence of a longer and distinct C-terminal sequence compared to isoform 1." [PMID:8358790, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-2

apoptosis regulator BAX isoform beta (human)

hBAX/iso:beta


"An apoptosis regulator BAX isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


sequence



PR:000002301

apoptosis regulator BAX isoform 3

BAX/iso:3


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-3 or a 1:1 ortholog thereof. Isoform 3 is about 40 residues long comprising the first 11 N-terminal residues in common to isoform 1 and a unique C-terminal sequence." [PMID:8358790, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-3

apoptosis regulator BAX isoform gamma (human)

hBAX/iso:gamma


"An apoptosis regulator BAX isoform 3 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


sequence



PR:000002302

apoptosis regulator BAX isoform 4

BAX/iso:4


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-4 or a 1:1 ortholog thereof. Isoform 4 has in common with isoform 1 the N-terminal (first 30 residues) and C-terminal regions, but differs from isoform 1 in that the former lacks a region of about 50 residues, that includes the BH3 motif region, therefore isoform 4 contains a partial copy of the Bcl-2 domain." [PMID:7607685, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-4

apoptosis regulator BAX isoform delta (human)

hBAX/iso:delta


"An apoptosis regulator BAX isoform 4 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


sequence



PR:000002303

apoptosis regulator BAX isoform 5

BAX/iso:5


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-5 or a 1:1 ortholog thereof. Isoform 5 differs from isoform 1 in that the former lacks the BH2 motif region, because it contains a different C-terminal sequence." [PMID:9920818, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-5

apoptosis regulator BAX isoform epsilon (human)

hBAX/iso:epsilon


"An apoptosis regulator BAX isoform 5 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


sequence



PR:000002304

apoptosis regulator BAX isoform 6

BAX/iso:6


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-6 or a 1:1 ortholog thereof. It lacks the N-terminal region up to the end of the BH3 motif. Isoform 6 contains a partial copy of the Bcl-2 domain." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-6

apoptosis regulator BAX isoform zeta (human)

hBAX/iso:zeta


"An apoptosis regulator BAX isoform 6 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


sequence



PR:000002305

apoptosis regulator BAX isoform 7

BAX/iso:7


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-7 or a 1:1 ortholog thereof. Isoform 7 is missing the N-terminal region of about 20 residues compared to isoform 1." [PMID:11912183, PRO:JAN, PRO:SY]


organism-sequence



PR:Q07812-7

apoptosis regulator BAX isoform psi (human)

hBAX/iso:psi


"An apoptosis regulator BAX isoform 7 that is encoded in the genome of human." [PRO:JAN, PRO:SY]


organism-sequence



PR:Q8K3J2

Bcl2-associated X protein kappa isoform (mouse)

mBAX/iso:7


"An apoptosis regulator BAX isoform 7 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]


sequence



PR:000002306

apoptosis regulator BAX isoform 8

BAX/iso:8


"An apoptosis regulator BAX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07812-8 or a 1:1 ortholog thereof. Isoform 8 differs from isoform 1 in that the former lacks the region between the BH2 motif region and the transmembrane domain." [PMID:10200554, PRO:SY]


organism-sequence



PR:Q07812-8

apoptosis regulator BAX isoform sigma (human)

hBAX/iso:sigma


"An apoptosis regulator BAX isoform 8 that is encoded in the genome of human." [PRO:SY]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q07813-1 mBAX/iso:Alpha acts_upstream_of_or_withinGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand MGI_ref:67275; PMID:8358790