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Protein Ontology report - CD14 molecule cleaved 2 soluble form
PR:000002147 -
http://purl.obolibrary.org/obo/PR_000002147
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000002147
PRO name
CD14 molecule cleaved 2 soluble form
Synonyms
PRO-Short-label
:
EXACT:
CD14/Clv:2/soluble
Other
:
EXACT:
monocyte differentiation antigen CD14 isoform 1 cleaved 2 | sCD14 48kd form | sCD14 alpha | sCD14 C form | sCD14 low M(r) form | Secreted form of CD14
Definition
"A CD14 molecule cleaved 2 that lacks the GPI-anchor." [
PMID:2779588
]
Comment
Note: This form appears to derive from release of the GPI-anchored form, mCD14.
PRO Category
modification
Parent
PR:000036848
CD14 molecule cleaved 2
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000002147
CD14 molecule cleaved 2 soluble form
CD14/Clv:2/soluble
Yes
organism-modification
PR:000029986
CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble
organism-modification
PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
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CD14/Clv:2/soluble
forms found in complexes
CD14/Clv:2/soluble
Component
Complexes
PR:000002147
CD14/Clv:2/soluble
PR:000025494
LPS:secreted CD14 alpha
PR:000025496
lipopolysaccharide receptor complex 2
PR:000025498
lipopolysaccharide receptor complex 4
PR:000035703
hCD14/Clv:2/soluble
PR:000037463
LPS:secreted CD14 alpha (human)
PR:000037479
lipopolysaccharide receptor complex 4 (human)
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Functional Annotation (GO-centric view)
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PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0034142
toll-like receptor 4 signaling pathway
PR:000035703
hCD14/Clv:2/soluble
Reactome:REACT_6894
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0001530
lipopolysaccharide binding
PR:000035703
hCD14/Clv:2/soluble
PMID:9464818
Cellular Location GO Term
Protein Forms & Complexes
Evidence
CL:0000129
microglial cell
PR:000035703
hCD14/Clv:2/soluble
PMID:24659539
GO:0005576
extracellular region
PR:000035703
hCD14/Clv:2/soluble
PMID:2779588
;
PMID:9665271
