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Protein Ontology report - signal transducer and activator of transcription 3
PR:000002089 - http://purl.obolibrary.org/obo/PR_000002089
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002089   
  PRO namesignal transducer and activator of transcription 3 
  Synonyms
PRO-Short-label: EXACT:STAT3
Gene-based: RELATED:APRF
Other: EXACT:acute-phase response factor
  Definition"A signal transducer and transcription activator STAT that is a translation product of the human STAT3 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001933 signal transducer and transcription activator STAT
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification1                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002089

signal transducer and activator of transcription 3

STAT3


"A signal transducer and transcription activator STAT that is a translation product of the human STAT3 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P40763

signal transducer and activator of transcription 3 (human)

hSTAT3


"A signal transducer and activator of transcription 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P40763]


organism-sequence



PR:P40763-1

signal transducer and activator of transcription 3 isoform 1 (human)

hSTAT3/iso:1


"A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000027924

signal transducer and activator of transcription 3 isoform 1 acetylated 1 (human)

hSTAT3/iso:1/Ac:1


"A signal transducer and activator of transcription 3 isoform 1 acetylated 1 in human. UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]


Yes
organism-sequence



PR:P40763-2

signal transducer and activator of transcription 3 isoform Del-701 (human)

hSTAT3/iso:Del-701


"A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P40763-3

signal transducer and activator of transcription 3 isoform h3 (human)

hSTAT3/iso:h3


"A signal transducer and activator of transcription 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-3." [PRO:DNx, UniProtKB:P40763]


organism-modification



PR:000045774

signal transducer and activator of transcription 3 phosphorylated 1 (human)

hSTAT3/Phos:1


"A signal transducer and activator of transcription 3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-705 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Tyr-705, MOD:00048." [iPTMnet:P40763, PMID:22306293, PMID:9083098]


organism-modification



PR:000060451

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated form (human)

hSTAT3/InitMet-/PhosRes+


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that includes at least one phosphorylated residue. Example: UniProtKB:P40763-1, 2-770, MOD:00696." [PRO:DNx, Reactome:R-HSA-8982823, Reactome:R-HSA-8983188]


organism-modification



PR:000063193

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated 1 (human)

hSTAT3/InitMet-/Phos:1


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-705 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, 2-770, Tyr-705, MOD:00048." [PRO:DNx, Reactome:R-HSA-8983130, Reactome:R-HSA-9027589]


organism-modification



PR:000086002

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated 2 (human)

hSTAT3/InitMet-/Phos:2


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-705 and Ser-727 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, 2-770, Tyr-705, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-539048]


organism-modification



PR:000060625

signal transducer and activator of transcription 3 phosphorylated 2 (human)

hSTAT3/Phos:2


"A signal transducer and activator of transcription 3 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-705 and Ser-727 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Tyr-705, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-9701429]


organism-modification



PR:000061182

signal transducer and activator of transcription 3 phosphorylated 3 (human)

hSTAT3/Phos:3


"A signal transducer and activator of transcription 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-727 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-198705]


organism-modification



PR:000063333

signal transducer and activator of transcription 3 acetylated and phosphorylated 1 (human)

hSTAT3/AcPhos:1


"A signal transducer and activator of transcription 3 (human) that has been acetylated on the residue at the position equivalent to Lys-685 and phosphorylated on the residues at the positions equivalent to Tyr-705 and Ser-727 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Lys-685, MOD:00064|Tyr-705, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-9701435]


organism-modification



PR:000064873

signal transducer and activator of transcription 3 cysteinylated 1 (human)

hSTAT3/Cyst:1


"A signal transducer and activator of transcription 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-108 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Cys-108, MOD:00765." [IEDB_epitope:924918, IEDB_epitope:930191, PRO:DNx]


organism-modification



PR:000069037

signal transducer and activator of transcription 3 methylated 1 (human)

hSTAT3/Me:1


"A signal transducer and activator of transcription 3 (human) that has been methylated on the residue at the position equivalent to Cys-712 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Cys-712, MOD:00660." [IEDB_epitope:1061716, PRO:DNx]


organism-modification



PR:000071577

signal transducer and activator of transcription 3 deaminated 1 (human)

hSTAT3/Deam:1


"A signal transducer and activator of transcription 3 (human) that has been deaminated on the residue at the position equivalent to Gln-20 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Gln-20, MOD:00685." [IEDB_epitope:777806, PRO:DNx]


organism-modification



PR:000078684

signal transducer and activator of transcription 3 hydroxylated 1 (human)

hSTAT3/Hy:1


"A signal transducer and activator of transcription 3 (human) that has been hydroxylated on the residue at the position equivalent to Pro-98 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Pro-98, MOD:00678." [IEDB_epitope:1324198, PRO:DNx]


organism-modification



PR:000079419

signal transducer and activator of transcription 3 cysteinylated 2 (human)

hSTAT3/Cyst:2


"A signal transducer and activator of transcription 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-328 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Cys-328, MOD:00765." [IEDB_epitope:772496, PRO:DNx]


organism-modification



PR:000079704

signal transducer and activator of transcription 3 deaminated 2 (human)

hSTAT3/Deam:2


"A signal transducer and activator of transcription 3 (human) that has been deaminated on the residue at the position equivalent to Gln-66 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Gln-66, MOD:00685." [IEDB_epitope:772560, PRO:DNx]


organism-modification



PR:000080405

signal transducer and activator of transcription 3 deaminated 3 (human)

hSTAT3/Deam:3


"A signal transducer and activator of transcription 3 (human) that has been deaminated on the residue at the position equivalent to Gln-67 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Gln-67, MOD:00685." [IEDB_epitope:772561, PRO:DNx]


organism-modification



PR:000083273

signal transducer and activator of transcription 3 methylated 2 (human)

hSTAT3/Me:2


"A signal transducer and activator of transcription 3 (human) that has been methylated on the residue at the position equivalent to Cys-328 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Cys-328, MOD:00660." [IEDB_epitope:1013939, PRO:DNx]


organism-modification



PR:000085869

signal transducer and activator of transcription 3, initiator methionine removed form (human)

hSTAT3/InitMet-


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed. Example: UniProtKB:P40763-1, 2-770." [PRO:DNx, Reactome:R-HSA-539044]


organism-modification



PR:000060451

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated form (human)

hSTAT3/InitMet-/PhosRes+


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that includes at least one phosphorylated residue. Example: UniProtKB:P40763-1, 2-770, MOD:00696." [PRO:DNx, Reactome:R-HSA-8982823, Reactome:R-HSA-8983188]


organism-modification



PR:000063193

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated 1 (human)

hSTAT3/InitMet-/Phos:1


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-705 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, 2-770, Tyr-705, MOD:00048." [PRO:DNx, Reactome:R-HSA-8983130, Reactome:R-HSA-9027589]


organism-modification



PR:000086002

signal transducer and activator of transcription 3, initiator methionine removed phosphorylated 2 (human)

hSTAT3/InitMet-/Phos:2


"A signal transducer and activator of transcription 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-705 and Ser-727 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, 2-770, Tyr-705, MOD:00048|Ser-727, MOD:00046." [PRO:DNx, Reactome:R-HSA-539048]


organism-gene



PR:P42227

signal transducer and activator of transcription 3 (mouse)

mSTAT3


"A signal transducer and activator of transcription 3 that is encoded in the genome of mouse." [OMA:P42227, PRO:DNx]


organism-sequence



PR:P42227-1

signal transducer and activator of transcription 3 isoform Stat3A (mouse)

mSTAT3/iso:Stat3A


"A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P42227]


organism-modification



PR:000037009

signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 1 (mouse)

mSTAT3/iso:Stat3A/Phos:1


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated on a residue equivalent to UniProtKB:P42227-1 Tyr-705. UniProtKB:P42227-1, Tyr-705, MOD:00048." [PMID:26026268, PRO:HJD]


organism-modification



PR:000045779

signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 2 (mouse)

mSTAT3/iso:Stat3A/Phos:2


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated at Ser-727 of the amino acid sequence represented by UniProtKB:P42227-1. UniProtKB:P42227-1, Ser-727, MOD:00046." [iPTMnet:P42227, PMID:14617800, PMID:15096606, PRO:CNA]


organism-modification



PR:000049778

signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 1 (mouse)

mSTAT3/iso:Stat3A/UnPhos:1


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at position Tyr-705. UniProtKB:P42227-1, Tyr-705, PR:000026291." [PMID:26764350, PRO:HJD]


organism-modification



PR:000049779

signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 2 (mouse)

mSTAT3/iso:Stat3A/UnPhos:2


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at the position equivalent to Ser-727. UniProtKB:P42227-1, Ser-727, PR:000026291." [PMID:26764350, PRO:HJD]


organism-sequence



PR:P42227-2

signal transducer and activator of transcription 3 isoform mStat3B (mouse)

mSTAT3/iso:mStat3B


"A signal transducer and activator of transcription 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42227-2." [PRO:DNx, UniProtKB:P42227]


organism-sequence



PR:P42227-3

signal transducer and activator of transcription 3 isoform Del-701 (mouse)

mSTAT3/iso:Del-701


"A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P52631

signal transducer and activator of transcription 3 (rat)

rSTAT3


"A signal transducer and activator of transcription 3 that is encoded in the genome of rat." [OMA:P52631, PRO:DNx]


organism-gene



PR:Q6DV79

signal transducer and activator of transcription 3 (chicken)

chick-STAT3


"A signal transducer and activator of transcription 3 that is encoded in the genome of chicken." [OMA:Q6DV79, PRO:DNx]


sequence



PR:000027921

signal transducer and activator of transcription 3 isoform 1

STAT3/iso:1


"A signal transducer and activator of transcription 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-1 or a 1:1 ortholog thereof." [PMID:15653507, PMID:19506034]


organism-sequence



PR:P40763-1

signal transducer and activator of transcription 3 isoform 1 (human)

hSTAT3/iso:1


"A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000027924

signal transducer and activator of transcription 3 isoform 1 acetylated 1 (human)

hSTAT3/iso:1/Ac:1


"A signal transducer and activator of transcription 3 isoform 1 acetylated 1 in human. UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]


Yes
organism-sequence



PR:P42227-1

signal transducer and activator of transcription 3 isoform Stat3A (mouse)

mSTAT3/iso:Stat3A


"A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P42227]


organism-modification



PR:000037009

signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 1 (mouse)

mSTAT3/iso:Stat3A/Phos:1


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated on a residue equivalent to UniProtKB:P42227-1 Tyr-705. UniProtKB:P42227-1, Tyr-705, MOD:00048." [PMID:26026268, PRO:HJD]


organism-modification



PR:000045779

signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 2 (mouse)

mSTAT3/iso:Stat3A/Phos:2


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated at Ser-727 of the amino acid sequence represented by UniProtKB:P42227-1. UniProtKB:P42227-1, Ser-727, MOD:00046." [iPTMnet:P42227, PMID:14617800, PMID:15096606, PRO:CNA]


organism-modification



PR:000049778

signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 1 (mouse)

mSTAT3/iso:Stat3A/UnPhos:1


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at position Tyr-705. UniProtKB:P42227-1, Tyr-705, PR:000026291." [PMID:26764350, PRO:HJD]


organism-modification



PR:000049779

signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 2 (mouse)

mSTAT3/iso:Stat3A/UnPhos:2


"A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at the position equivalent to Ser-727. UniProtKB:P42227-1, Ser-727, PR:000026291." [PMID:26764350, PRO:HJD]


modification



PR:000027923

signal transducer and activator of transcription 3 isoform 1 acetylated 1

STAT3/iso:1/Ac:1


"A signal transducer and activator of transcription 3 isoform 1 that has been acetylated on a Lys residue within the conserved sequence FGKYC, and elicited by the internalization of CD44. Example: UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]


organism-modification



PR:000027924

signal transducer and activator of transcription 3 isoform 1 acetylated 1 (human)

hSTAT3/iso:1/Ac:1


"A signal transducer and activator of transcription 3 isoform 1 acetylated 1 in human. UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]


Yes
sequence



PR:000039402

signal transducer and activator of transcription 3 isoform Del-701

STAT3/iso:Del-701


"A signal transducer and activator of transcription 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P40763-2

signal transducer and activator of transcription 3 isoform Del-701 (human)

hSTAT3/iso:Del-701


"A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P42227-3

signal transducer and activator of transcription 3 isoform Del-701 (mouse)

mSTAT3/iso:Del-701


"A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of mouse." [PRO:DNx]


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STAT3 forms found in complexes   

STAT3 Component
Complexes
PR:000027924 hSTAT3/iso:1/Ac:1 PR:000027938 acetylated STAT3 homodimer (human)