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Protein Ontology report - interferon regulatory factor 5
PR:000002047 - http://purl.obolibrary.org/obo/PR_000002047
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002047   
  PRO nameinterferon regulatory factor 5 
  Synonyms
PRO-Short-label: EXACT:IRF5
Other: EXACT:IRF-5
  Definition"An interferon regulatory factor 3-9 that is a translation product of the human IRF5 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001863 interferon regulatory factor 3-9
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 8                                        
         Modification3                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002047

interferon regulatory factor 5

IRF5


"An interferon regulatory factor 3-9 that is a translation product of the human IRF5 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P56477

interferon regulatory factor 5 (mouse)

mIRF5


"An interferon regulatory factor 5 that is encoded in the genome of mouse." [OMA:P56477, PRO:DNx]


organism-sequence



PR:B2CC69

interferon regulatory factor 5 isoform 2 (mouse)

mIRF5/iso:2


"An interferon regulatory factor 5 isoform 2 that is encoded in the genome of mouse. This isoform contains contains an internal deletion of most of exons 4 to 6 in comparison to isoform 1." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027096

interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse)

mIRF5/iso:2/Phos:1


"An interferon regulatory factor 5 isoform 2 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
organism-sequence



PR:P56477-1

interferon regulatory factor 5 isoform 1 (mouse)

mIRF5/iso:1


"An interferon regulatory factor 5 isoform 1 that is encoded in the genome of mouse." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027094

interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse)

mIRF5/iso:1/Phos:1


"An interferon regulatory factor 5 isoform 1 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
organism-modification



PR:000027535

interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse)

mIRF5/iso:1/K63polyUbiq:1


"An interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P56477-1, Lys-410/Lys-411, PR:000044772." [PMID:18824541, PRO:CNA, TLR:AMM]


organism-gene



PR:Q13568

interferon regulatory factor 5 (human)

hIRF5


"An interferon regulatory factor 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q13568]


organism-sequence



PR:Q13568-1

interferon regulatory factor 5 isoform 1 (human)

hIRF5/iso:1


"An interferon regulatory factor 5 isoform 1 that is encoded in the genome of human." [PMID:15805103, PRO:CNA]


organism-sequence



PR:Q13568-2

interferon regulatory factor 5 isoform h2 (human)

hIRF5/iso:h2


"An interferon regulatory factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13568-2." [PRO:DNx, UniProtKB:Q13568]


organism-sequence



PR:Q13568-3

interferon regulatory factor 5 isoform h3 (human)

hIRF5/iso:h3


"An interferon regulatory factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13568-3." [PRO:DNx, UniProtKB:Q13568]


organism-sequence



PR:Q13568-4

interferon regulatory factor 5 isoform h4 (human)

hIRF5/iso:h4


"An interferon regulatory factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13568-4." [PRO:DNx, UniProtKB:Q13568]


organism-sequence



PR:Q13568-5

interferon regulatory factor 5 isoform h5 (human)

hIRF5/iso:h5


"An interferon regulatory factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13568-5." [PRO:DNx, UniProtKB:Q13568]


organism-sequence



PR:Q13568-6

interferon regulatory factor 5 isoform h6 (human)

hIRF5/iso:h6


"An interferon regulatory factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13568-6." [PRO:DNx, UniProtKB:Q13568]


organism-modification



PR:000065832

interferon regulatory factor 5 methylated 1 (human)

hIRF5/Me:1


"An interferon regulatory factor 5 (human) that has been methylated on the residue at the position equivalent to Cys-44 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Cys-44, MOD:00660." [IEDB_epitope:1014736, PRO:DNx]


organism-modification



PR:000065856

interferon regulatory factor 5 cysteinylated 1 (human)

hIRF5/Cyst:1


"An interferon regulatory factor 5 (human) that has been cysteinylated on the residue at the position equivalent to Cys-28 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Cys-28, MOD:00765." [IEDB_epitope:1004203, PRO:DNx]


organism-modification



PR:000071639

interferon regulatory factor 5 methylated 2 (human)

hIRF5/Me:2


"An interferon regulatory factor 5 (human) that has been methylated on the residue at the position equivalent to Cys-357 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Cys-357, MOD:00660." [IEDB_epitope:1006130, PRO:DNx]


organism-modification



PR:000075034

interferon regulatory factor 5 methylated 3 (human)

hIRF5/Me:3


"An interferon regulatory factor 5 (human) that has been methylated on the residue at the position equivalent to Cys-272 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Cys-272, MOD:00660." [IEDB_epitope:1022240, IEDB_epitope:1022241, IEDB_epitope:1050429, PRO:DNx]


organism-modification



PR:000079300

interferon regulatory factor 5 citrullinated 1 (human)

hIRF5/Cit:1


"An interferon regulatory factor 5 (human) that has been citrullinated on the residue at the position equivalent to Arg-424 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Arg-424, MOD:00219." [IEDB_epitope:1309057, PRO:DNx]


organism-modification



PR:000081350

interferon regulatory factor 5 cysteinylated 2 (human)

hIRF5/Cyst:2


"An interferon regulatory factor 5 (human) that has been cysteinylated on the residue at the position equivalent to Cys-272 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Cys-272, MOD:00765." [IEDB_epitope:1022239, PRO:DNx]


organism-modification



PR:000085949

interferon regulatory factor 5 phosphorylated 1 (human)

hIRF5/Phos:1


"An interferon regulatory factor 5 (human) that has been phosphorylated on the residue at the position equivalent to Ser-446 of the amino acid sequence represented by UniProtKB:Q13568-1. Example: UniProtKB:Q13568-1, Ser-446, MOD:00046." [PRO:DNx, Reactome:R-HSA-9860271, Reactome:R-HSA-9860304]


organism-gene



PR:Q5ZJM5

uncharacterized protein, RCJMB04_17b14 translation product (chicken)

chick-IRF5


"An interferon regulatory factor 5 that is encoded in the genome of chicken." [PRO:DAN]


sequence



PR:000027087

interferon regulatory factor 5 isoform 1

IRF5/iso:1


"An interferon regulatory factor 5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56477-1 or a 1:1 ortholog thereof." [PMID:18332133, PRO:CNA]


organism-sequence



PR:P56477-1

interferon regulatory factor 5 isoform 1 (mouse)

mIRF5/iso:1


"An interferon regulatory factor 5 isoform 1 that is encoded in the genome of mouse." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027094

interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse)

mIRF5/iso:1/Phos:1


"An interferon regulatory factor 5 isoform 1 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
organism-modification



PR:000027535

interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse)

mIRF5/iso:1/K63polyUbiq:1


"An interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P56477-1, Lys-410/Lys-411, PR:000044772." [PMID:18824541, PRO:CNA, TLR:AMM]


organism-sequence



PR:Q13568-1

interferon regulatory factor 5 isoform 1 (human)

hIRF5/iso:1


"An interferon regulatory factor 5 isoform 1 that is encoded in the genome of human." [PMID:15805103, PRO:CNA]


modification



PR:000027093

interferon regulatory factor 5 isoform 1 phosphorylated 1

IRF5/iso:1/Phos:1


"An interferon regulatory factor 5 isoform 1 that has been phosphorylated on Ser residues within the C-terminal region, leading to a conformational change and promoting dimerization." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027094

interferon regulatory factor 5 isoform 1 phosphorylated 1 (mouse)

mIRF5/iso:1/Phos:1


"An interferon regulatory factor 5 isoform 1 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
modification



PR:000027534

interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1

IRF5/iso:1/Ubiq:1


"An interferon regulatory factor 5 isoform 1 that has been K63-linked polyubiquitinated in response to TLR/MyD88-dependent signaling. Ubiquitinated by TRAF6. Example: UniProtKB:P56477-1, Lys-410/Lys-411, PR:000044772." [PMID:18824541, PRO:CNA]


organism-modification



PR:000027535

interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 (mouse)

mIRF5/iso:1/K63polyUbiq:1


"An interferon regulatory factor 5 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P56477-1, Lys-410/Lys-411, PR:000044772." [PMID:18824541, PRO:CNA, TLR:AMM]


sequence



PR:000027090

interferon regulatory factor 5 isoform 2

IRF5/iso:2


"An interferon regulatory factor 5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B2CC69 or a 1:1 ortholog thereof." [PMID:18332133, PRO:CNA]


organism-sequence



PR:B2CC69

interferon regulatory factor 5 isoform 2 (mouse)

mIRF5/iso:2


"An interferon regulatory factor 5 isoform 2 that is encoded in the genome of mouse. This isoform contains contains an internal deletion of most of exons 4 to 6 in comparison to isoform 1." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027096

interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse)

mIRF5/iso:2/Phos:1


"An interferon regulatory factor 5 isoform 2 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
modification



PR:000027095

interferon regulatory factor 5 isoform 2 phosphorylated 1

IRF5/iso:2/Phos:1


"An interferon regulatory factor 5 isoform 2 that has been phosphorylated on Ser residues within the C-terminal region, leading to a conformational change and promoting dimerization." [PMID:18332133, PRO:CNA]


organism-modification



PR:000027096

interferon regulatory factor 5 isoform 2 phosphorylated 1 (mouse)

mIRF5/iso:2/Phos:1


"An interferon regulatory factor 5 isoform 2 phosphorylated 1 in mouse." [PMID:18332133, PRO:CNA]


Yes
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IRF5 forms found in complexes   

IRF5 Component
Complexes
PR:000027094 mIRF5/iso:1/Phos:1 PR:000027536 IRF5-P:IRF5-P (mouse)
PR:000027096 mIRF5/iso:2/Phos:1 PR:000027537 IRF5BMv-P:IRF5BMv-P (mouse)