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Protein Ontology report - T-cell-specific surface glycoprotein CD28
PR:000001841 - http://purl.obolibrary.org/obo/PR_000001841
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001841   
  PRO nameT-cell-specific surface glycoprotein CD28 
  Synonyms
PRO-Short-label: EXACT:CD28
Other: EXACT:TP44
  Definition"A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 8                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2863
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001841
T-cell-specific surface glycoprotein CD28
CD28
"A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:P10747
T-cell-specific surface glycoprotein CD28 (human)
hCD28
"A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10747]

organism-sequence


PR:P10747-1
T-cell-specific surface glycoprotein CD28 isoform 1 (human)
hCD28/iso:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
organism-sequence


PR:P10747-2
T-cell-specific surface glycoprotein CD28 isoform h2 (human)
hCD28/iso:h2
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-2." [PRO:DNx, UniProtKB:P10747]

organism-sequence


PR:P10747-3
T-cell-specific surface glycoprotein CD28 isoform h3 (human)
hCD28/iso:h3
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-3." [PRO:DNx, UniProtKB:P10747]

organism-sequence


PR:P10747-4
T-cell-specific surface glycoprotein CD28 isoform h4 (human)
hCD28/iso:h4
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-4." [PRO:DNx, UniProtKB:P10747]

organism-sequence


PR:P10747-5
T-cell-specific surface glycoprotein CD28 isoform h5 (human)
hCD28/iso:h5
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-5." [PRO:DNx, UniProtKB:P10747]

organism-sequence


PR:P10747-6
T-cell-specific surface glycoprotein CD28 isoform h6 (human)
hCD28/iso:h6
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-6." [PRO:DNx, UniProtKB:P10747]

organism-sequence


PR:P10747-7
T-cell-specific surface glycoprotein CD28 isoform h7 (human)
hCD28/iso:h7
"A T-cell-specific surface glycoprotein CD28 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-7." [PRO:DNx, UniProtKB:P10747]

organism-modification


PR:000026870
T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
hCD28/SigPep-
"A T-cell-specific surface glycoprotein CD28, signal peptide removed form in human. Example: UniProtKB:P10747-1, 19-220." [PRO:CNA, Reactome:R-HSA-167628, Reactome:R-HSA-167632]

organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
organism-modification


PR:000071913
T-cell-specific surface glycoprotein CD28 cysteinylated 1 (human)
hCD28/Cyst:1
"A T-cell-specific surface glycoprotein CD28 (human) that has been cysteinylated on the residue at the position equivalent to Cys-66 of the amino acid sequence represented by UniProtKB:P10747-1. Example: UniProtKB:P10747-1, Cys-66, MOD:00765." [IEDB_epitope:1047728, PRO:DNx]

organism-modification


PR:000075395
T-cell-specific surface glycoprotein CD28 methylated 1 (human)
hCD28/Me:1
"A T-cell-specific surface glycoprotein CD28 (human) that has been methylated on the residue at the position equivalent to Cys-40 of the amino acid sequence represented by UniProtKB:P10747-1. Example: UniProtKB:P10747-1, Cys-40, MOD:00660." [IEDB_epitope:1035025, PRO:DNx]

organism-modification


PR:000078595
T-cell-specific surface glycoprotein CD28 methylated 2 (human)
hCD28/Me:2
"A T-cell-specific surface glycoprotein CD28 (human) that has been methylated on the residue at the position equivalent to Cys-66 of the amino acid sequence represented by UniProtKB:P10747-1. Example: UniProtKB:P10747-1, Cys-66, MOD:00660." [IEDB_epitope:1047729, PRO:DNx]

organism-gene


PR:P31041
T-cell-specific surface glycoprotein CD28 (mouse)
mCD28
"A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of mouse." [OMA:P31041, PRO:DNx]

organism-sequence


PR:P31041-1
T-cell-specific surface glycoprotein CD28 isoform 1 (mouse)
mCD28/iso:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-gene


PR:P31042
T-cell-specific surface glycoprotein CD28 (rat)
rCD28
"A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of rat." [OMA:P31042, PRO:DNx]

organism-gene


PR:P31043
T-cell-specific surface glycoprotein CD28 homolog (chicken)
chick-CD28
"A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of chicken." [PRO:WCB]

sequence


PR:000025788
T-cell-specific surface glycoprotein CD28 isoform 1
CD28/iso:1
"A T-cell-specific surface glycoprotein CD28 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P10747-1
T-cell-specific surface glycoprotein CD28 isoform 1 (human)
hCD28/iso:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
organism-sequence


PR:P31041-1
T-cell-specific surface glycoprotein CD28 isoform 1 (mouse)
mCD28/iso:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000026613
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed form
CD28/iso:1/SigPep-
"A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000025789
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
CD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed and has been phosphorylated on the Tyr residue within the C-terminal YMNM motif by LCK. Example: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA, PRO:DAN]

Yes
organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
modification


PR:000018541
T-cell-specific surface glycoprotein CD28, signal peptide removed form
CD28/SigPep-
"A T-cell-specific surface glycoprotein CD28 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000026613
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed form
CD28/iso:1/SigPep-
"A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000025789
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
CD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed and has been phosphorylated on the Tyr residue within the C-terminal YMNM motif by LCK. Example: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA, PRO:DAN]

Yes
organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
organism-modification


PR:000026870
T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
hCD28/SigPep-
"A T-cell-specific surface glycoprotein CD28, signal peptide removed form in human. Example: UniProtKB:P10747-1, 19-220." [PRO:CNA, Reactome:R-HSA-167628, Reactome:R-HSA-167632]

organism-modification


PR:000025790
T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
hCD28/iso:1/SigPep-/Phos:1
"A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048." [PMID:8992971, PRO:CNA]
Yes
Yes
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CD28 forms found in complexes   

CD28 Component
 Complexes
PR:000025789 CD28/iso:1/SigPep-/Phos:1 PR:000025791 phospho CD28 homodimer
PR:000025790 hCD28/iso:1/SigPep-/Phos:1 PR:000025792 phospho CD28 homodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025790 hCD28/iso:1/SigPep-/Phos:1
UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048		 located_inGO:0005886 plasma membrane Reactome:REACT_20178