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Protein Ontology report - interleukin-6 receptor subunit alpha isoform 1 soluble form

PR:000001798 - http://purl.obolibrary.org/obo/PR_000001798

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000001798

PRO name

interleukin-6 receptor subunit alpha isoform 1 soluble form

Synonyms

PRO-Short-label:	EXACT:	IL6R/iso:1/Clv:soluble
Other:	EXACT:	sIL-6R

Definition

"An interleukin-6 receptor subunit alpha isoform 1 that has been post-translationally cleaved to release the extracellular domain into the extracellular space." [PMID:8477802, PRO:HJD]

PRO Category

modification

Parent

PR:000001794 interleukin-6 receptor subunit alpha isoform 1
PR:000025429 interleukin-6 receptor subunit alpha proteolytic cleavage product

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	1	Organism-Modification	1

Term Hierarchy
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DAG:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

modification

PR:000001798 interleukin-6 receptor subunit alpha isoform 1 soluble form

IL6R/iso:1/Clv:soluble

organism-modification

PR:000044514 interleukin-6 receptor subunit alpha isoform 1 soluble form (mouse)

mIL6R/iso:1/Clv:soluble

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000044514 mIL6R/iso:1/Clv:soluble	acts_upstream_of_or_within	GO:0070102 interleukin-6-mediated signaling pathway	PMID:8477802
	enables	GO:0004915 interleukin-6 receptor activity	PMID:8477802
	enables	GO:0019981 interleukin-6 binding	PMID:8477802
	located_in	GO:0005615 extracellular space	PMID:8477802