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Protein Ontology report - interleukin-1 receptor-associated kinase 3
PR:000001784 - http://purl.obolibrary.org/obo/PR_000001784
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001784   
  PRO nameinterleukin-1 receptor-associated kinase 3 
  Synonyms
PRO-Short-label: EXACT:IRAK3
Other: EXACT:IL-1 receptor-associated kinase M | inactive IL-1 receptor-associated kinase 3 | IRAK-3 | IRAK-M
  Definition"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof." [PMID:12150927, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001781 interleukin-1 receptor-associated kinase IRAK1/3
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2044
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001784

interleukin-1 receptor-associated kinase 3

IRAK3


"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof." [PMID:12150927, PRO:CNA]


organism-gene



PR:G5ECP4

pelle-like serine/threonine-protein kinase pik-1 (worm)

IRAK3 (worm)


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of worm." [PRO:CNA]


organism-sequence



PR:G5ECP4-1

pelle-like serine/threonine-protein kinase pik-1 isoform a (worm)

IRAK3/iso:a (worm)


"A pelle-like serine/threonine-protein kinase pik-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5ECP4-1." [PRO:DNx, UniProtKB:G5ECP4]


organism-sequence



PR:G5ECP4-2

pelle-like serine/threonine-protein kinase pik-1 isoform b (worm)

IRAK3/iso:b (worm)


"A pelle-like serine/threonine-protein kinase pik-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5ECP4-2." [PRO:DNx, UniProtKB:G5ECP4]


organism-gene



PR:Q8K4B2

interleukin-1 receptor-associated kinase 3 (mouse)

mIRAK3


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of mouse." [OMA:Q8K4B2, PMID:12150927, PRO:CNA]

Yes

Yes
organism-gene



PR:Q9Y616

interleukin-1 receptor-associated kinase 3 (human)

hIRAK3


"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y616]


organism-sequence



PR:Q9Y616-1

interleukin-1 receptor-associated kinase 3 isoform 1 (human)

hIRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]

Yes

organism-sequence



PR:Q9Y616-2

interleukin-1 receptor-associated kinase 3 isoform h2 (human)

hIRAK3/iso:h2


"An interleukin-1 receptor-associated kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y616-2." [PRO:DNx, UniProtKB:Q9Y616]


organism-modification



PR:000073219

interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human)

hIRAK3/Phos:1


"An interleukin-1 receptor-associated kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-335 of the amino acid sequence represented by UniProtKB:Q9Y616-1. Example: UniProtKB:Q9Y616-1, Ser-335, MOD:00046." [IEDB_epitope:912152, PRO:DNx]


sequence



PR:000027241

interleukin-1 receptor-associated kinase 3 isoform 1

IRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y616-1 or a 1:1 ortholog thereof." [GenBank:AF113136, PMID:10383454, PRO:CNA]


organism-sequence



PR:Q9Y616-1

interleukin-1 receptor-associated kinase 3 isoform 1 (human)

hIRAK3/iso:1


"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]

Yes

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IRAK3 forms found in complexes   

IRAK3 Component
Complexes
PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8K4B2 mIRAK3 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927
PR:Q9Y616-1 hIRAK3/iso:1 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454