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Documentation
Protein Ontology report - interleukin-1 receptor-associated kinase IRAK1/3
PR:000001781 -
http://purl.obolibrary.org/obo/PR_000001781
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000001781
PRO name
interleukin-1 receptor-associated kinase IRAK1/3
Definition
"A protein with core domain architecture consisting of an N-terminal Death domain (
Pfam:PF00531
) followed by a Protein kinase domain (
Pfam:PF00069
). This class is closely related to IRAK-4 (
PR:000001780
), but it contains an extra C-terminal region of about 200 residues." [
PMID:12620219
]
PRO Category
family
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
3
Organism-Gene
9
Sequence
2
Organism-Sequence
14
Modification
5
Organism-Modification
17
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF038190
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000001781
interleukin-1 receptor-associated kinase IRAK1/3
IRAK4
gene
PR:000001782
interleukin-1 receptor-associated kinase 1
IRAK1
organism-gene
PR:P51617
interleukin-1 receptor-associated kinase 1 (human)
hIRAK1
organism-sequence
PR:P51617-1
interleukin-1 receptor-associated kinase 1 isoform 1 (human)
hIRAK1/iso:1
Yes
organism-modification
PR:000027492
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
organism-modification
PR:000027493
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification
PR:000027494
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification
PR:000061935
interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+
organism-sequence
PR:P51617-2
interleukin-1 receptor-associated kinase 1 isoform h2 (human)
hIRAK1/iso:h2
organism-sequence
PR:P51617-3
interleukin-1 receptor-associated kinase 1 isoform h3 (human)
hIRAK1/iso:h3
organism-sequence
PR:P51617-4
interleukin-1 receptor-associated kinase 1 isoform h4 (human)
hIRAK1/iso:h4
organism-modification
PR:000048042
interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human)
hIRAK1/Phos:5
organism-modification
PR:000048043
interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human)
hIRAK1/Phos:1
organism-modification
PR:000048044
interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human)
hIRAK1/Phos:3
organism-modification
PR:000062298
interleukin-1 receptor-associated kinase 1 phosphorylated 2 (human)
hIRAK1/Phos:2
organism-modification
PR:000064197
interleukin-1 receptor-associated kinase 1 phosphoserine and phosphothreonine form (human)
hIRAK1/pSerThr+
organism-modification
PR:000064772
interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human)
hIRAK1/PhosUbiq:1
organism-gene
PR:Q62406
interleukin-1 receptor-associated kinase 1 (mouse)
mIRAK1
Yes
organism-sequence
PR:Q62406-1
interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)
mIRAK1/iso:1
organism-modification
PR:000027178
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1
Yes
organism-modification
PR:000027179
interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
mIRAK1/iso:1/UnMod
Yes
organism-sequence
PR:Q62406-2
interleukin-1 receptor-associated kinase 1 isoform m2 (mouse)
mIRAK1/iso:m2
sequence
PR:000021973
interleukin-1 receptor-associated kinase 1 isoform 1
IRAK1/iso:1
organism-sequence
PR:P51617-1
interleukin-1 receptor-associated kinase 1 isoform 1 (human)
hIRAK1/iso:1
Yes
organism-modification
PR:000027492
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
organism-modification
PR:000027493
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification
PR:000027494
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification
PR:000061935
interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+
organism-sequence
PR:Q62406-1
interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)
mIRAK1/iso:1
organism-modification
PR:000027178
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1
Yes
organism-modification
PR:000027179
interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
mIRAK1/iso:1/UnMod
Yes
modification
PR:000021971
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
IRAK1/iso:1/PhosRes+
modification
PR:000021975
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
IRAK1/iso:1/Phos:1
organism-modification
PR:000027178
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1
Yes
organism-modification
PR:000027494
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
Yes
Yes
modification
PR:000021977
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
IRAK1/iso:1/Phos:3
organism-modification
PR:000027492
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
hIRAK1/iso:1/Phos:3
Yes
modification
PR:000021978
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4
IRAK1/iso:1/Phos:4
organism-modification
PR:000027493
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
hIRAK1/iso:1/Phos:4
Yes
organism-modification
PR:000061935
interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)
hIRAK1/iso:1/pSerThr+
modification
PR:000021974
interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form
IRAK1/iso:1/UnMod
organism-modification
PR:000027179
interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
mIRAK1/iso:1/UnMod
Yes
gene
PR:000001783
interleukin-1 receptor-associated kinase-like 2
IRAK2
organism-gene
PR:F1N826
uncharacterized protein, IRAK2 translation product (chicken)
chick-IRAK2
organism-gene
PR:O43187
interleukin-1 receptor-associated kinase-like 2 (human)
hIRAK2
organism-modification
PR:000048045
interleukin-1 receptor-associated kinase-like 2 phosphorylated form (human)
hIRAK2/PhosRes+
organism-modification
PR:000081167
interleukin-1 receptor-associated kinase-like 2 cysteinylated 1 (human)
hIRAK2/Cyst:1
organism-modification
PR:000081833
interleukin-1 receptor-associated kinase-like 2 cysteinylated 2 (human)
hIRAK2/Cyst:2
organism-modification
PR:000082521
interleukin-1 receptor-associated kinase-like 2 cysteinylated 3 (human)
hIRAK2/Cyst:3
organism-gene
PR:Q4QQS0
interleukin-1 receptor-associated kinase-like 2 (rat)
rIRAK2
organism-gene
PR:Q8CFA1
interleukin-1 receptor-associated kinase-like 2 (mouse)
mIRAK2
organism-sequence
PR:Q8CFA1-1
interleukin-1 receptor-associated kinase-like 2 isoform m1 (mouse)
mIRAK2/iso:m1
organism-sequence
PR:Q8CFA1-2
interleukin-1 receptor-associated kinase-like 2 isoform m2 (mouse)
mIRAK2/iso:m2
organism-sequence
PR:Q8CFA1-3
interleukin-1 receptor-associated kinase-like 2 isoform m3 (mouse)
mIRAK2/iso:m3
organism-sequence
PR:Q8CFA1-4
interleukin-1 receptor-associated kinase-like 2 isoform m4 (mouse)
mIRAK2/iso:m4
gene
PR:000001784
interleukin-1 receptor-associated kinase 3
IRAK3
organism-gene
PR:G5ECP4
pelle-like serine/threonine-protein kinase pik-1 (worm)
IRAK3 (worm)
organism-sequence
PR:G5ECP4-1
pelle-like serine/threonine-protein kinase pik-1 isoform a (worm)
IRAK3/iso:a (worm)
organism-sequence
PR:G5ECP4-2
pelle-like serine/threonine-protein kinase pik-1 isoform b (worm)
IRAK3/iso:b (worm)
organism-gene
PR:Q8K4B2
interleukin-1 receptor-associated kinase 3 (mouse)
mIRAK3
Yes
Yes
organism-gene
PR:Q9Y616
interleukin-1 receptor-associated kinase 3 (human)
hIRAK3
organism-sequence
PR:Q9Y616-1
interleukin-1 receptor-associated kinase 3 isoform 1 (human)
hIRAK3/iso:1
Yes
organism-sequence
PR:Q9Y616-2
interleukin-1 receptor-associated kinase 3 isoform h2 (human)
hIRAK3/iso:h2
organism-modification
PR:000073219
interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human)
hIRAK3/Phos:1
sequence
PR:000027241
interleukin-1 receptor-associated kinase 3 isoform 1
IRAK3/iso:1
organism-sequence
PR:Q9Y616-1
interleukin-1 receptor-associated kinase 3 isoform 1 (human)
hIRAK3/iso:1
Yes
Back to top
IRAK4
forms found in complexes
IRAK4
Component
Complexes
PR:000027178
mIRAK1/iso:1/Phos:1
PR:000027221
pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179
mIRAK1/iso:1/UnMod
PR:000027220
IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027253
IRAK1:tollip complex (mouse)
PR:000027494
hIRAK1/iso:1/Phos:1
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q62406
mIRAK1
PR:000027267
IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q8K4B2
mIRAK3
PR:000027267
IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0034122
negative regulation of toll-like receptor signaling pathway
PR:Q8K4B2
mIRAK3
PMID:12150927
PR:Q9Y616-1
hIRAK3/iso:1
PMID:10383454
GO:0070498
interleukin-1-mediated signaling pathway
PR:000027492
hIRAK1/iso:1/Phos:3
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:P51617-1
hIRAK1/iso:1
PMID:14625308
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004674
protein serine/threonine kinase activity
PR:000027492
hIRAK1/iso:1/Phos:3
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
GO:0005515
protein binding
PR:000027494
hIRAK1/iso:1/Phos:1
PMID:11960013
PR:P51617-1
hIRAK1/iso:1
PMID:14625308
PR:P51617-1
hIRAK1/iso:1
PMID:14625308
PR:Q9Y616-1
hIRAK3/iso:1
PMID:10383454
NOT
GO:0005515
protein binding
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
PR:000027493
hIRAK1/iso:1/Phos:4
PMID:14625308
GO:0016301
kinase activity
PR:000027494
hIRAK1/iso:1/Phos:1
PMID:11960013
