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Protein Ontology report - serine/threonine-protein kinase TBK1
PR:000001779 - http://purl.obolibrary.org/obo/PR_000001779
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001779   
  PRO nameserine/threonine-protein kinase TBK1 
  Synonyms
PRO-Short-label: EXACT:TBK1
Gene-based: RELATED:NAK
Other: EXACT:NF-kappa-B-activating kinase | T2K | TANK-binding kinase 1
  Definition"An IKK-related kinase that is a translation product of the human TBK1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001777 IKK-related kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification1                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2237
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001779

serine/threonine-protein kinase TBK1

TBK1


"An IKK-related kinase that is a translation product of the human TBK1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q9UHD2

serine/threonine-protein kinase TBK1 (human)

hTBK1


"A serine/threonine-protein kinase TBK1 that is encoded in the genome of human." [PMID:17327220, PRO:CNA, Reactome:R-HSA-166267]


organism-sequence



PR:Q9UHD2-1

serine/threonine-protein kinase TBK1 isoform 1 (human)

hTBK1/iso:1


"A serine/threonine-protein kinase TBK1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028695

serine/threonine-protein kinase TBK1 phosphorylated 1 (human)

hTBK1/Phos:1


"A serine/threonine-protein kinase TBK1 phosphorylated 1 in human. UniProtKB:Q9UHD2, Ser-172, MOD:00046." [PRO:CNA]


Yes
organism-modification



PR:000045519

serine/threonine-protein kinase TBK1 phosphorylated 2 (human)

hTBK1/Phos:2


"A serine/threonine-protein kinase TBK1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-527 in UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Ser-527, MOD:00046." [PMID:26407194, PRO:CNA]


organism-modification



PR:000064841

serine/threonine-protein kinase TBK1 phosphorylated and ubiquitinated 1 (human)

hTBK1/PhosUbiq:1


"A serine/threonine-protein kinase TBK1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-172 and ubiquitinated on the residue at the position equivalent to Lys-670 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Ser-172, MOD:00046|Lys-670, MOD:01148." [PRO:DNx, Reactome:R-HSA-3249397]


organism-modification



PR:000066943

serine/threonine-protein kinase TBK1 methylated 1 (human)

hTBK1/Me:1


"A serine/threonine-protein kinase TBK1 (human) that has been methylated on the residue at the position equivalent to Cys-605 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Cys-605, MOD:00660." [IEDB_epitope:1013457, PRO:DNx]


organism-modification



PR:000068123

serine/threonine-protein kinase TBK1 deaminated 1 (human)

hTBK1/Deam:1


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-330 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-330, MOD:00684." [IEDB_epitope:635471, PRO:DNx]


organism-modification



PR:000070007

serine/threonine-protein kinase TBK1 cysteinylated 1 (human)

hTBK1/Cyst:1


"A serine/threonine-protein kinase TBK1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-605 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Cys-605, MOD:00765." [IEDB_epitope:878347, PRO:DNx]


organism-modification



PR:000075441

serine/threonine-protein kinase TBK1 deaminated 2 (human)

hTBK1/Deam:2


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-66 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-66, MOD:00684." [IEDB_epitope:1800864, PRO:DNx]


organism-modification



PR:000077131

serine/threonine-protein kinase TBK1 deaminated 3 (human)

hTBK1/Deam:3


"A serine/threonine-protein kinase TBK1 (human) that has been deaminated on the residue at the position equivalent to Asn-557 of the amino acid sequence represented by UniProtKB:Q9UHD2. UniProtKB:Q9UHD2, Asn-557, MOD:00684." [IEDB_epitope:1984490, PRO:DNx]


organism-gene



PR:Q9WUN2

serine/threonine-protein kinase TBK1 (mouse)

mTBK1


"A serine/threonine-protein kinase TBK1 that is encoded in the genome of mouse." [OMA:Q9WUN2, PRO:CNA]


Yes
organism-modification



PR:000080978

serine/threonine-protein kinase TBK1 cysteinylated 1 (mouse)

mTBK1/Cyst:1


"A serine/threonine-protein kinase TBK1 (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-728 of the amino acid sequence represented by UniProtKB:Q9WUN2. UniProtKB:Q9WUN2, Cys-728, MOD:00765." [IEDB_epitope:2094575, PRO:DNx]


sequence



PR:000028692

serine/threonine-protein kinase TBK1 isoform 1

TBK1/iso:1


"A serine/threonine-protein kinase TBK1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UHD2-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q9UHD2-1

serine/threonine-protein kinase TBK1 isoform 1 (human)

hTBK1/iso:1


"A serine/threonine-protein kinase TBK1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000028694

serine/threonine-protein kinase TBK1 phosphorylated 1

TBK1/Phos:1


"A serine/threonine-protein kinase TBK1 that has been phosphorylated on a conserved Ser residue within the Protein Kinase domain (Pfam:PF00069). Example: UniProtKB:Q9UHD2, Ser-172, MOD:00046." [PRO:CNA, Reactome:R-HSA-450290]


organism-modification



PR:000028695

serine/threonine-protein kinase TBK1 phosphorylated 1 (human)

hTBK1/Phos:1


"A serine/threonine-protein kinase TBK1 phosphorylated 1 in human. UniProtKB:Q9UHD2, Ser-172, MOD:00046." [PRO:CNA]


Yes
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TBK1 forms found in complexes   

TBK1 Component
Complexes
PR:000028695 hTBK1/Phos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q9WUN2 mTBK1 PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036149 tbk1:tank:ikke complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)