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Protein Ontology report - inhibitor of nuclear factor kappa-B kinase subunit alpha
PR:000001775 - http://purl.obolibrary.org/obo/PR_000001775
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001775   
  PRO nameinhibitor of nuclear factor kappa-B kinase subunit alpha 
  Synonyms
PRO-Short-label: EXACT:CHUK
Gene-based: RELATED:IKKA | TCF16
Other: EXACT:conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IkappaB kinase | IkBKA | IKK-A | IKK-alpha | IKK1 | NFKBIKA | nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | transcription factor 16
  Definition"An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001774 inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1989
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001775
inhibitor of nuclear factor kappa-B kinase subunit alpha
CHUK
"An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:O15111
inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
hCHUK
"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111]

Yes
organism-sequence


PR:O15111-1
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
hCHUK/iso:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]

organism-modification


PR:000026823
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
hCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]

Yes
organism-modification


PR:000045576
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human)
hCHUK/Phos:2
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated at Thr-23. UniProtKB:O15111, Thr-23, MOD:00047." [iPTMnet:O15111, PMID:10485710, Reactome:R-HSA-177667, Reactome:R-HSA-198615]

organism-modification


PR:000062311
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 1 (human)
hCHUK/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Ser-176 and Ser-180 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Ser-176/Ser-180, MOD:00046." [PRO:DNx, Reactome:R-HSA-177667]

organism-modification


PR:000065276
inhibitor of nuclear factor kappa-B kinase subunit alpha methylated 1 (human)
hCHUK/Me:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been methylated on the residue at the position equivalent to Thr-319 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Thr-319, MOD:01418." [IEDB_epitope:1319554, PRO:DNx]

organism-modification


PR:000085410
inhibitor of nuclear factor kappa-B kinase subunit alpha deaminated 1 (human)
hCHUK/Deam:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been deaminated on the residue at the position equivalent to Gln-63 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Gln-63, MOD:00685." [IEDB_epitope:1778644, PRO:DNx]

organism-modification


PR:000085871
inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 3 (human)
hCHUK/Phos:3
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-187 and Tyr-198 of the amino acid sequence represented by UniProtKB:O15111. UniProtKB:O15111, Tyr-187/Tyr-198, MOD:00048." [PRO:DNx, Reactome:R-HSA-9861501]

organism-gene


PR:Q4G3H4
inhibitor of nuclear factor kappa-B kinase subunit alpha (zebrafish)
z-CHUK
"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of zebrafish." [PRO:CNA]

organism-gene


PR:Q5ZJB4
inhibitor of nuclear factor kappa-B kinase subunit alpha (chicken)
chick-CHUK
"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of chicken." [PRO:CNA]

organism-gene


PR:Q60680
inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse)
mCHUK
"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of mouse." [OMA:Q60680, PRO:DNx]

organism-sequence


PR:Q60680-1
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse)
mCHUK/iso:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNx]

Yes
organism-modification


PR:000036121
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
mCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]

Yes
organism-sequence


PR:Q60680-2
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m2 (mouse)
mCHUK/iso:m2
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-2." [PRO:DNx, UniProtKB:Q60680]

organism-sequence


PR:Q60680-3
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m3 (mouse)
mCHUK/iso:m3
"An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-3." [PRO:DNx, UniProtKB:Q60680]

sequence


PR:000026820
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
CHUK/iso:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15111-1 or a 1:1 ortholog thereof." [PRO:CNx]

organism-sequence


PR:O15111-1
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
hCHUK/iso:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]

organism-modification


PR:000026823
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
hCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]

Yes
organism-sequence


PR:Q60680-1
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse)
mCHUK/iso:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNx]

Yes
organism-modification


PR:000036121
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
mCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]

Yes
modification


PR:000026822
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
CHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that has been phosphorylated in the two Ser residues within the activation loop. Example: UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]

organism-modification


PR:000026823
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
hCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]

Yes
organism-modification


PR:000036121
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
mCHUK/iso:1/Phos:1
"An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]

Yes
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CHUK forms found in complexes   

CHUK Component
 Complexes
PR:000026823 hCHUK/iso:1/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:000036121 mCHUK/iso:1/Phos:1 PR:000036119 activated IkappaB kinase complex (mouse)
PR:O15111 hCHUK PR:000026457 IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q60680ZDASHZ1 mCHUK/iso:1 PR:000036118 IkappaB kinase complex (mouse)